Optimal vortex formation time index in mitral valve stenosis
Left ventricular vortex formation time (VFT) is a novel dimensionless index of flow propagation during left ventricular diastole, which has been demonstrated to be useful in heart failure and cardiomyopathy. In mitral stenosis (MS), flow propagation in the LV may be suboptimal. We studied VFT in var...
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| Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2021-05, Vol.37 (5), p.1595-1600 |
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| creator | Ambhore, Anand Ngiam, Jinghao Nicholas Chew, Nicholas W. S. Pramotedham, Thanawin Loh, Joshua P. Y. Kang, Giap Swee Poh, Kian-Keong |
| description | Left ventricular vortex formation time (VFT) is a novel dimensionless index of flow propagation during left ventricular diastole, which has been demonstrated to be useful in heart failure and cardiomyopathy. In mitral stenosis (MS), flow propagation in the LV may be suboptimal. We studied VFT in varying degrees of MS. Echocardiography was performed on 20 healthy controls and 50 cases of rheumatic MS. Patients with atrial fibrillation, LV ejection fraction |
| doi_str_mv | 10.1007/s10554-020-02140-9 |
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2
= 0.463, p < 0.001) and total LA emptying fraction (R
2
= 0.348, p < 0.001), and positively correlated with LA volume index (R
2
= 0.440, p < 0.001) and mean transmitral pressure gradient (R
2
= 0.336, p < 0.001). More severe MS correlated with suboptimal (higher) VFT. The restricted mitral valve opening may disrupt vortex formation and optimal fluid propagation in the LV. Despite the compensatory increase in LA size with increasingly severe MS, reduced LA function also contributed to the suboptimal LV vortex formation.]]></description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-020-02140-9</identifier><identifier>PMID: 33433748</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cardiac Imaging ; Cardiology ; Cardiomyopathy ; Cardiovascular diseases ; Congestive heart failure ; Continuous radiation ; Coronary artery disease ; Correlation ; Diastole ; Echocardiography ; Fibrillation ; Fluid flow ; Heart diseases ; Heart valves ; Imaging ; Medicine ; Medicine & Public Health ; Mitral valve ; Original Paper ; Propagation ; Radiology ; Stenosis ; Ventricle ; Vortices</subject><ispartof>The International Journal of Cardiovascular Imaging, 2021-05, Vol.37 (5), p.1595-1600</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3d4417f50a34e269eee3d9eb74a04991368f25f2c141c8f6baf9b2a077cfeb723</citedby><cites>FETCH-LOGICAL-c375t-3d4417f50a34e269eee3d9eb74a04991368f25f2c141c8f6baf9b2a077cfeb723</cites><orcidid>0000-0002-3339-7281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-020-02140-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-020-02140-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33433748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambhore, Anand</creatorcontrib><creatorcontrib>Ngiam, Jinghao Nicholas</creatorcontrib><creatorcontrib>Chew, Nicholas W. S.</creatorcontrib><creatorcontrib>Pramotedham, Thanawin</creatorcontrib><creatorcontrib>Loh, Joshua P. Y.</creatorcontrib><creatorcontrib>Kang, Giap Swee</creatorcontrib><creatorcontrib>Poh, Kian-Keong</creatorcontrib><title>Optimal vortex formation time index in mitral valve stenosis</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description><![CDATA[Left ventricular vortex formation time (VFT) is a novel dimensionless index of flow propagation during left ventricular diastole, which has been demonstrated to be useful in heart failure and cardiomyopathy. In mitral stenosis (MS), flow propagation in the LV may be suboptimal. We studied VFT in varying degrees of MS. Echocardiography was performed on 20 healthy controls and 50 cases of rheumatic MS. Patients with atrial fibrillation, LV ejection fraction < 50% and other valvular heart diseases were excluded. VFT was obtained using the length-to-diameter ratio (L/D), where L is the continuous-wave Doppler velocity time integral stroke distance, divided by D, the mitral leaflet separation index. This was correlated against varying degrees of MS severity, left atrial (LA) volume and function. In controls, VFT was 3.92 ± 2.00 (optimal range) and was higher (suboptimal) with increasing severity of mitral stenosis (4.98 ± 2.43 in mild MS; 7.22 ± 2.98 in moderate MS; 11.55 ± 2.67 in severe MS, p < 0.001). VFT negatively correlated with mitral valve area (R
2
= 0.463, p < 0.001) and total LA emptying fraction (R
2
= 0.348, p < 0.001), and positively correlated with LA volume index (R
2
= 0.440, p < 0.001) and mean transmitral pressure gradient (R
2
= 0.336, p < 0.001). More severe MS correlated with suboptimal (higher) VFT. The restricted mitral valve opening may disrupt vortex formation and optimal fluid propagation in the LV. Despite the compensatory increase in LA size with increasingly severe MS, reduced LA function also contributed to the suboptimal LV vortex formation.]]></description><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular diseases</subject><subject>Congestive heart failure</subject><subject>Continuous radiation</subject><subject>Coronary artery disease</subject><subject>Correlation</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Fibrillation</subject><subject>Fluid flow</subject><subject>Heart diseases</subject><subject>Heart valves</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitral valve</subject><subject>Original Paper</subject><subject>Propagation</subject><subject>Radiology</subject><subject>Stenosis</subject><subject>Ventricle</subject><subject>Vortices</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1LwzAYx4Mobk6_gAcpePFSzWuzgBcZvsFgFz2HtH0iHW0zk3bot19qp4IHDyHhye_5P8kPoXOCrwnG8iYQLARPMcVxEY5TdYCmREiWYsnZ4XDOVCqk4hN0EsIa44hSdowmjHHGJJ9P0e1q01WNqZOt8x18JNb5xnSVa5NYhqRqy1is2qSpOj9Qpt5CEjpoXajCKTqypg5wtt9n6PXh_mXxlC5Xj8-Lu2VaMCm6lJWcE2kFNowDzRQAsFJBLrnBXCnCsrmlwtKCcFLMbZYbq3JqsJSFjRRlM3Q15m68e-8hdLqpQgF1bVpwfdCUS0mz4UcRvfyDrl3v2_g6TQWlKuOSsEjRkSq8C8GD1RsfLfhPTbAe3OrRrY7C9JdbrWLTxT66zxsof1q-ZUaAjUCIV-0b-N_Z_8TuABU3g0E</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Ambhore, Anand</creator><creator>Ngiam, Jinghao Nicholas</creator><creator>Chew, Nicholas W. 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S. ; Pramotedham, Thanawin ; Loh, Joshua P. Y. ; Kang, Giap Swee ; Poh, Kian-Keong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3d4417f50a34e269eee3d9eb74a04991368f25f2c141c8f6baf9b2a077cfeb723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac Imaging</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular diseases</topic><topic>Congestive heart failure</topic><topic>Continuous radiation</topic><topic>Coronary artery disease</topic><topic>Correlation</topic><topic>Diastole</topic><topic>Echocardiography</topic><topic>Fibrillation</topic><topic>Fluid flow</topic><topic>Heart diseases</topic><topic>Heart valves</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitral valve</topic><topic>Original Paper</topic><topic>Propagation</topic><topic>Radiology</topic><topic>Stenosis</topic><topic>Ventricle</topic><topic>Vortices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambhore, Anand</creatorcontrib><creatorcontrib>Ngiam, Jinghao Nicholas</creatorcontrib><creatorcontrib>Chew, Nicholas W. S.</creatorcontrib><creatorcontrib>Pramotedham, Thanawin</creatorcontrib><creatorcontrib>Loh, Joshua P. Y.</creatorcontrib><creatorcontrib>Kang, Giap Swee</creatorcontrib><creatorcontrib>Poh, Kian-Keong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambhore, Anand</au><au>Ngiam, Jinghao Nicholas</au><au>Chew, Nicholas W. S.</au><au>Pramotedham, Thanawin</au><au>Loh, Joshua P. Y.</au><au>Kang, Giap Swee</au><au>Poh, Kian-Keong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal vortex formation time index in mitral valve stenosis</atitle><jtitle>The International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>37</volume><issue>5</issue><spage>1595</spage><epage>1600</epage><pages>1595-1600</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><abstract><![CDATA[Left ventricular vortex formation time (VFT) is a novel dimensionless index of flow propagation during left ventricular diastole, which has been demonstrated to be useful in heart failure and cardiomyopathy. In mitral stenosis (MS), flow propagation in the LV may be suboptimal. We studied VFT in varying degrees of MS. Echocardiography was performed on 20 healthy controls and 50 cases of rheumatic MS. Patients with atrial fibrillation, LV ejection fraction < 50% and other valvular heart diseases were excluded. VFT was obtained using the length-to-diameter ratio (L/D), where L is the continuous-wave Doppler velocity time integral stroke distance, divided by D, the mitral leaflet separation index. This was correlated against varying degrees of MS severity, left atrial (LA) volume and function. In controls, VFT was 3.92 ± 2.00 (optimal range) and was higher (suboptimal) with increasing severity of mitral stenosis (4.98 ± 2.43 in mild MS; 7.22 ± 2.98 in moderate MS; 11.55 ± 2.67 in severe MS, p < 0.001). VFT negatively correlated with mitral valve area (R
2
= 0.463, p < 0.001) and total LA emptying fraction (R
2
= 0.348, p < 0.001), and positively correlated with LA volume index (R
2
= 0.440, p < 0.001) and mean transmitral pressure gradient (R
2
= 0.336, p < 0.001). More severe MS correlated with suboptimal (higher) VFT. The restricted mitral valve opening may disrupt vortex formation and optimal fluid propagation in the LV. Despite the compensatory increase in LA size with increasingly severe MS, reduced LA function also contributed to the suboptimal LV vortex formation.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33433748</pmid><doi>10.1007/s10554-020-02140-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3339-7281</orcidid></addata></record> |
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| subjects | Cardiac Imaging Cardiology Cardiomyopathy Cardiovascular diseases Congestive heart failure Continuous radiation Coronary artery disease Correlation Diastole Echocardiography Fibrillation Fluid flow Heart diseases Heart valves Imaging Medicine Medicine & Public Health Mitral valve Original Paper Propagation Radiology Stenosis Ventricle Vortices |
| title | Optimal vortex formation time index in mitral valve stenosis |
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