Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study
Background Vascular calcification contributes to morbidity and mortality in patients with ESRD on maintenance hemodialysis. Aims To study the relationship between osteocalcin and vascular calcification. Methods 160 patients with ESRD on maintenance hemodialysis and 60 age-and sex-matched healthy con...
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| Veröffentlicht in: | International urology and nephrology 2021-05, Vol.53 (5), p.1015-1023 |
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| container_title | International urology and nephrology |
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| creator | Keryakos, Hesham Kamal Habeeb Okaily, Nagwa Ismail Boulis, Mariam Asaad Yacoub Salama, Ahmed Mohamed Saadeldin |
| description | Background
Vascular calcification contributes to morbidity and mortality in patients with ESRD on maintenance hemodialysis.
Aims
To study the relationship between osteocalcin and vascular calcification.
Methods
160 patients with ESRD on maintenance hemodialysis and 60 age-and sex-matched healthy controls were recruited. Serum vitamin K2 and osteocalcin both intact and undercarboxylated were measured. Transthoracic echocardiography was done for valvular calcification and thickening, and carotid duplex was done for carotid intimal medial calcification and thickening.
Results
Hemodialysis patients have higher median serum vitamin K2 (
p
|
| doi_str_mv | 10.1007/s11255-020-02753-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2477263332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2477263332</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ac8d7e2c02eca6bff331e824b5c3c490db89d20a1949658871013ff7595c91d73</originalsourceid><addsrcrecordid>eNp9kE1L7DAUhoMoOn78AReXghs31ZOcZNK6k8EvENzo1pCmqVY6zdycVui_N854r-DCRQic87xvwsPYMYczDqDPiXOhVA4C0tEK82mLzbjSmAtVyG02AwSe87nAPbZP9AYAZQGwy_YQJaIuyhl7fqDBB2c71_aZ7evs3ZIbOxuz9axpnR3a0Gdp--qXoW5tN1FL2SqNfT_QRQploSIf39eg7TIXXkMcMhrGejpkO43tyB993Qfs6frqcXGb3z_c3C0u73OHWg25dUWtvXAgvLPzqmkQuS-ErJRDJ0uoq6KsBVheynKuikJz4Ng0WpXKlbzWeMBON72rGP6OngazbMn5rrO9DyMZIbUWc0QUCT35gb6FMaaPJ0oJACmVVIkSG8rFQBR9Y1axXdo4GQ7m077Z2DfJvlnbN1MK_fmqHqulr_9H_ulOAG4ASqv-xcfvt3-p_QAGf5Do</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520044545</pqid></control><display><type>article</type><title>Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Keryakos, Hesham Kamal Habeeb ; Okaily, Nagwa Ismail ; Boulis, Mariam Asaad Yacoub ; Salama, Ahmed Mohamed Saadeldin</creator><creatorcontrib>Keryakos, Hesham Kamal Habeeb ; Okaily, Nagwa Ismail ; Boulis, Mariam Asaad Yacoub ; Salama, Ahmed Mohamed Saadeldin</creatorcontrib><description>Background
Vascular calcification contributes to morbidity and mortality in patients with ESRD on maintenance hemodialysis.
Aims
To study the relationship between osteocalcin and vascular calcification.
Methods
160 patients with ESRD on maintenance hemodialysis and 60 age-and sex-matched healthy controls were recruited. Serum vitamin K2 and osteocalcin both intact and undercarboxylated were measured. Transthoracic echocardiography was done for valvular calcification and thickening, and carotid duplex was done for carotid intimal medial calcification and thickening.
Results
Hemodialysis patients have higher median serum vitamin K2 (
p
< 0.001), higher undercarboxylated osteocalcin (
p
< 0.001). Only older age, duration of hypertension, and duration of established cardiovascular disease are associated with carotid media-intimal calcification. Old age is a strong predictor of carotid media intimal thickening. Female sex is associated with a valvular thickening.
Conclusions
Functional vitamin K deficiency is present in maintenance hemodialysis patients and serum osteocalcin is not associated with cardiovascular calcification.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-020-02753-y</identifier><identifier>PMID: 33433789</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Calcification ; Calcification (ectopic) ; Cardiovascular diseases ; Cohort analysis ; Echocardiography ; Hemodialysis ; Medicine ; Medicine & Public Health ; Menaquinones ; Morbidity ; Nephrology ; Nephrology - Original Paper ; Observational studies ; Osteocalcin ; Urology ; Vitamin deficiency ; Vitamin K</subject><ispartof>International urology and nephrology, 2021-05, Vol.53 (5), p.1015-1023</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ac8d7e2c02eca6bff331e824b5c3c490db89d20a1949658871013ff7595c91d73</citedby><cites>FETCH-LOGICAL-c375t-ac8d7e2c02eca6bff331e824b5c3c490db89d20a1949658871013ff7595c91d73</cites><orcidid>0000-0003-3443-6390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-020-02753-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-020-02753-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33433789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keryakos, Hesham Kamal Habeeb</creatorcontrib><creatorcontrib>Okaily, Nagwa Ismail</creatorcontrib><creatorcontrib>Boulis, Mariam Asaad Yacoub</creatorcontrib><creatorcontrib>Salama, Ahmed Mohamed Saadeldin</creatorcontrib><title>Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background
Vascular calcification contributes to morbidity and mortality in patients with ESRD on maintenance hemodialysis.
Aims
To study the relationship between osteocalcin and vascular calcification.
Methods
160 patients with ESRD on maintenance hemodialysis and 60 age-and sex-matched healthy controls were recruited. Serum vitamin K2 and osteocalcin both intact and undercarboxylated were measured. Transthoracic echocardiography was done for valvular calcification and thickening, and carotid duplex was done for carotid intimal medial calcification and thickening.
Results
Hemodialysis patients have higher median serum vitamin K2 (
p
< 0.001), higher undercarboxylated osteocalcin (
p
< 0.001). Only older age, duration of hypertension, and duration of established cardiovascular disease are associated with carotid media-intimal calcification. Old age is a strong predictor of carotid media intimal thickening. Female sex is associated with a valvular thickening.
Conclusions
Functional vitamin K deficiency is present in maintenance hemodialysis patients and serum osteocalcin is not associated with cardiovascular calcification.</description><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular diseases</subject><subject>Cohort analysis</subject><subject>Echocardiography</subject><subject>Hemodialysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menaquinones</subject><subject>Morbidity</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Observational studies</subject><subject>Osteocalcin</subject><subject>Urology</subject><subject>Vitamin deficiency</subject><subject>Vitamin K</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1L7DAUhoMoOn78AReXghs31ZOcZNK6k8EvENzo1pCmqVY6zdycVui_N854r-DCRQic87xvwsPYMYczDqDPiXOhVA4C0tEK82mLzbjSmAtVyG02AwSe87nAPbZP9AYAZQGwy_YQJaIuyhl7fqDBB2c71_aZ7evs3ZIbOxuz9axpnR3a0Gdp--qXoW5tN1FL2SqNfT_QRQploSIf39eg7TIXXkMcMhrGejpkO43tyB993Qfs6frqcXGb3z_c3C0u73OHWg25dUWtvXAgvLPzqmkQuS-ErJRDJ0uoq6KsBVheynKuikJz4Ng0WpXKlbzWeMBON72rGP6OngazbMn5rrO9DyMZIbUWc0QUCT35gb6FMaaPJ0oJACmVVIkSG8rFQBR9Y1axXdo4GQ7m077Z2DfJvlnbN1MK_fmqHqulr_9H_ulOAG4ASqv-xcfvt3-p_QAGf5Do</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Keryakos, Hesham Kamal Habeeb</creator><creator>Okaily, Nagwa Ismail</creator><creator>Boulis, Mariam Asaad Yacoub</creator><creator>Salama, Ahmed Mohamed Saadeldin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3443-6390</orcidid></search><sort><creationdate>20210501</creationdate><title>Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study</title><author>Keryakos, Hesham Kamal Habeeb ; Okaily, Nagwa Ismail ; Boulis, Mariam Asaad Yacoub ; Salama, Ahmed Mohamed Saadeldin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ac8d7e2c02eca6bff331e824b5c3c490db89d20a1949658871013ff7595c91d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiovascular diseases</topic><topic>Cohort analysis</topic><topic>Echocardiography</topic><topic>Hemodialysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menaquinones</topic><topic>Morbidity</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Observational studies</topic><topic>Osteocalcin</topic><topic>Urology</topic><topic>Vitamin deficiency</topic><topic>Vitamin K</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keryakos, Hesham Kamal Habeeb</creatorcontrib><creatorcontrib>Okaily, Nagwa Ismail</creatorcontrib><creatorcontrib>Boulis, Mariam Asaad Yacoub</creatorcontrib><creatorcontrib>Salama, Ahmed Mohamed Saadeldin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keryakos, Hesham Kamal Habeeb</au><au>Okaily, Nagwa Ismail</au><au>Boulis, Mariam Asaad Yacoub</au><au>Salama, Ahmed Mohamed Saadeldin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>53</volume><issue>5</issue><spage>1015</spage><epage>1023</epage><pages>1015-1023</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Background
Vascular calcification contributes to morbidity and mortality in patients with ESRD on maintenance hemodialysis.
Aims
To study the relationship between osteocalcin and vascular calcification.
Methods
160 patients with ESRD on maintenance hemodialysis and 60 age-and sex-matched healthy controls were recruited. Serum vitamin K2 and osteocalcin both intact and undercarboxylated were measured. Transthoracic echocardiography was done for valvular calcification and thickening, and carotid duplex was done for carotid intimal medial calcification and thickening.
Results
Hemodialysis patients have higher median serum vitamin K2 (
p
< 0.001), higher undercarboxylated osteocalcin (
p
< 0.001). Only older age, duration of hypertension, and duration of established cardiovascular disease are associated with carotid media-intimal calcification. Old age is a strong predictor of carotid media intimal thickening. Female sex is associated with a valvular thickening.
Conclusions
Functional vitamin K deficiency is present in maintenance hemodialysis patients and serum osteocalcin is not associated with cardiovascular calcification.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33433789</pmid><doi>10.1007/s11255-020-02753-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3443-6390</orcidid></addata></record> |
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| subjects | Calcification Calcification (ectopic) Cardiovascular diseases Cohort analysis Echocardiography Hemodialysis Medicine Medicine & Public Health Menaquinones Morbidity Nephrology Nephrology - Original Paper Observational studies Osteocalcin Urology Vitamin deficiency Vitamin K |
| title | Osteocalcin and vascular calcification in hemodialysis patients: an observational cohort study |
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