P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt

Purpose P-selectin glycoprotein ligand-1 (PSGL-1) acts as a crucial regulator for the inflammatory cells infiltration by mediating the adhesion of leukocytes. However, the role of PSGL-1 in aortic aneurysm remains elusive. Here, we investigated the role of PSGL-1 in aortic aneurysm (AA) development....

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Veröffentlicht in:	Cardiovascular drugs and therapy 2022-02, Vol.36 (1), p.31-44
Hauptverfasser:	Wu, Xianxian, Liu, Xing, Yang, Hang, Chen, Qianlong, Zhang, Na, Li, Yuhan, Du, Xingchen, Liu, Xue, Jiang, Xiaoliang, Jiang, Yideng, Zhou, Zhou, Yang, Zhiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adhesion Animal models Animals Aorta Aortic Aneurysm - genetics Aortic Aneurysm - physiopathology Aortic aneurysms Attenuation Cardiology Cell Adhesion - physiology Cell migration Cell Movement - physiology Cells, Cultured Collagen Degeneration Desoxycorticosterone Acetate Disease Models, Animal Elastin Endothelial Cells - metabolism Flow cytometry Glycoproteins Humans Immunofluorescence Infiltration Inflammation Inflammation - genetics Inflammation - physiopathology Leukocytes Leukocytes - metabolism Ligands Male Medicine Medicine & Public Health Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Muscles NF-κB protein Original Article P-selectin P-selectin glycoprotein ligand 1 Patient Acuity Smooth muscle Sodium Chloride, Dietary Therapeutic targets Western blotting
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