Difference of pain vulnerability in adult and juvenile rodents: the role of SIRT1-mediated ClC-3 trafficking in sensory neurons

Adults are more likely to suffer from chronic pain than minors, and its underlying mechanism remains unclear. SIRT1 an important age-related protein with function of lifespan extension; whether SIRT1 plays a role in the different pain vulnerability of adult and juvenile remains unclear. Here, we fou...

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Veröffentlicht in:	Pain (Amsterdam) 2021-06, Vol.162 (6), p.1882-1896
Hauptverfasser:	Zhang, Xiao-Long, Zhang, Jin-Jun, Chen, Zi-Hang, Yang, Kai-Bin, Zhang, Xi, Xiao, Yi-Bin, Lei, Yi, Cao, Xian-Ying, Xie, Man-Xiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ganglia, Spinal Humans Rats Rats, Sprague-Dawley Rodentia Sensory Receptor Cells Sirtuin 1 - genetics
Online-Zugang:	Volltext
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