Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding
Background: In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities. Methods: A retrospective revie...
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| Veröffentlicht in: | Journal of child neurology 2021-06, Vol.36 (7), p.575-582 |
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| container_title | Journal of child neurology |
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| creator | Harini, Chellamani Yuskaitis, Christopher J. Libenson, Mark H. Yang, Edward DeLeo, Michelle Zhang, Bo Mysak, Kate Marti, Candice Peters, Jurriaan M. Bergin, Ann Marie Pearl, Phillip L. Prabhu, Sanjay P. |
| description | Background:
In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities.
Methods:
A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features.
Results:
In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes.
Conclusions:
Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance. |
| doi_str_mv | 10.1177/0883073820985395 |
| format | Article |
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In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities.
Methods:
A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features.
Results:
In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes.
Conclusions:
Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/0883073820985395</identifier><identifier>PMID: 33432856</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Anticonvulsants - therapeutic use ; Female ; Hippocampus - diagnostic imaging ; Hippocampus - drug effects ; Hippocampus - pathology ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Retrospective Studies ; Spasms, Infantile - diagnostic imaging ; Spasms, Infantile - drug therapy ; Vigabatrin - therapeutic use</subject><ispartof>Journal of child neurology, 2021-06, Vol.36 (7), p.575-582</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-417071a71b47bc81b9284592ac0a2994fe947d8073d129ad5dc6dc3223f930843</citedby><cites>FETCH-LOGICAL-c337t-417071a71b47bc81b9284592ac0a2994fe947d8073d129ad5dc6dc3223f930843</cites><orcidid>0000-0002-6725-2814 ; 0000-0002-9912-4163 ; 0000-0003-0871-115X ; 0000-0002-6373-1068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0883073820985395$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0883073820985395$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33432856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harini, Chellamani</creatorcontrib><creatorcontrib>Yuskaitis, Christopher J.</creatorcontrib><creatorcontrib>Libenson, Mark H.</creatorcontrib><creatorcontrib>Yang, Edward</creatorcontrib><creatorcontrib>DeLeo, Michelle</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Mysak, Kate</creatorcontrib><creatorcontrib>Marti, Candice</creatorcontrib><creatorcontrib>Peters, Jurriaan M.</creatorcontrib><creatorcontrib>Bergin, Ann Marie</creatorcontrib><creatorcontrib>Pearl, Phillip L.</creatorcontrib><creatorcontrib>Prabhu, Sanjay P.</creatorcontrib><title>Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>Background:
In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities.
Methods:
A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features.
Results:
In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes.
Conclusions:
Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.</description><subject>Anticonvulsants - therapeutic use</subject><subject>Female</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Spasms, Infantile - diagnostic imaging</subject><subject>Spasms, Infantile - drug therapy</subject><subject>Vigabatrin - therapeutic use</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLw0AUhQdRbK3uXcks3UTnkXRm3JWituCL1scy3CSTOmUyiZlpQfzzprS6EFzdC-c7B85B6JSSC0qFuCRSciK4ZETJhKtkD_WpIDKSTPJ91N_I0UbvoSPvl4QQmShyiHqcx5zJZNhHXxPTNHUOVQMWT926tmtdaRfwmwnv-NUsIIPQGhfNtIWgC3w_m-K5WbgOH2WubiuwJhjtsXH4CbrPBb81T10JLhir8bwBX_krPMIP9VpbfGNcYdziGB2UYL0-2d0Berm5fh5PorvH2-l4dBflnIsQxV0lQUHQLBZZLmmmmIwTxSAnwJSKS61iUciuZ0GZgiIp8mGRc8Z4qTiRMR-g821u09YfK-1DWhmfa2vB6XrlUxYLwYaE82GHki2at7X3rS7TpjUVtJ8pJelm8vTv5J3lbJe-yipd_Bp-Nu6AaAt4WOh0Wa_abjz_f-A3hEuIZw</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Harini, Chellamani</creator><creator>Yuskaitis, Christopher J.</creator><creator>Libenson, Mark H.</creator><creator>Yang, Edward</creator><creator>DeLeo, Michelle</creator><creator>Zhang, Bo</creator><creator>Mysak, Kate</creator><creator>Marti, Candice</creator><creator>Peters, Jurriaan M.</creator><creator>Bergin, Ann Marie</creator><creator>Pearl, Phillip L.</creator><creator>Prabhu, Sanjay P.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6725-2814</orcidid><orcidid>https://orcid.org/0000-0002-9912-4163</orcidid><orcidid>https://orcid.org/0000-0003-0871-115X</orcidid><orcidid>https://orcid.org/0000-0002-6373-1068</orcidid></search><sort><creationdate>202106</creationdate><title>Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding</title><author>Harini, Chellamani ; Yuskaitis, Christopher J. ; Libenson, Mark H. ; Yang, Edward ; DeLeo, Michelle ; Zhang, Bo ; Mysak, Kate ; Marti, Candice ; Peters, Jurriaan M. ; Bergin, Ann Marie ; Pearl, Phillip L. ; Prabhu, Sanjay P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-417071a71b47bc81b9284592ac0a2994fe947d8073d129ad5dc6dc3223f930843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticonvulsants - therapeutic use</topic><topic>Female</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Spasms, Infantile - diagnostic imaging</topic><topic>Spasms, Infantile - drug therapy</topic><topic>Vigabatrin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harini, Chellamani</creatorcontrib><creatorcontrib>Yuskaitis, Christopher J.</creatorcontrib><creatorcontrib>Libenson, Mark H.</creatorcontrib><creatorcontrib>Yang, Edward</creatorcontrib><creatorcontrib>DeLeo, Michelle</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Mysak, Kate</creatorcontrib><creatorcontrib>Marti, Candice</creatorcontrib><creatorcontrib>Peters, Jurriaan M.</creatorcontrib><creatorcontrib>Bergin, Ann Marie</creatorcontrib><creatorcontrib>Pearl, Phillip L.</creatorcontrib><creatorcontrib>Prabhu, Sanjay P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harini, Chellamani</au><au>Yuskaitis, Christopher J.</au><au>Libenson, Mark H.</au><au>Yang, Edward</au><au>DeLeo, Michelle</au><au>Zhang, Bo</au><au>Mysak, Kate</au><au>Marti, Candice</au><au>Peters, Jurriaan M.</au><au>Bergin, Ann Marie</au><au>Pearl, Phillip L.</au><au>Prabhu, Sanjay P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding</atitle><jtitle>Journal of child neurology</jtitle><addtitle>J Child Neurol</addtitle><date>2021-06</date><risdate>2021</risdate><volume>36</volume><issue>7</issue><spage>575</spage><epage>582</epage><pages>575-582</pages><issn>0883-0738</issn><eissn>1708-8283</eissn><abstract>Background:
In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities.
Methods:
A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features.
Results:
In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes.
Conclusions:
Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>33432856</pmid><doi>10.1177/0883073820985395</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6725-2814</orcidid><orcidid>https://orcid.org/0000-0002-9912-4163</orcidid><orcidid>https://orcid.org/0000-0003-0871-115X</orcidid><orcidid>https://orcid.org/0000-0002-6373-1068</orcidid></addata></record> |
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| ispartof | Journal of child neurology, 2021-06, Vol.36 (7), p.575-582 |
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| language | eng |
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| source | Access via SAGE; MEDLINE |
| subjects | Anticonvulsants - therapeutic use Female Hippocampus - diagnostic imaging Hippocampus - drug effects Hippocampus - pathology Humans Infant Magnetic Resonance Imaging Male Retrospective Studies Spasms, Infantile - diagnostic imaging Spasms, Infantile - drug therapy Vigabatrin - therapeutic use |
| title | Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding |
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