Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam
Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Ana...
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| Veröffentlicht in: | International journal of biological macromolecules 2021-02, Vol.171, p.389-397 |
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| container_title | International journal of biological macromolecules |
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| creator | Butle, Ashwin B. Talmale, Suhas A. Jadhao, Vivek V. Patil, Mandakini B. Lambat, Trimurti L. |
| description | Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Anaphylaxis is a severe life-threatening allergic reaction and Arthus reaction is deposition of immune complex and complement system activation, so we hypothesized that if ZMSL can protect these severe allergic diseases. We have studied the effect of ZMSL on macrophages and Wistar albino rats and confirmed its protective effect against anaphylaxis and Arthus reaction. Results of this study suggest ZMSL have immunostimulatory and antiallergic activity.
ZMSL isolated from edible fruit seed was found to have potential for immunostimulatory and immunosuppressive activity. [Display omitted] |
| doi_str_mv | 10.1016/j.ijbiomac.2021.01.027 |
| format | Article |
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ZMSL isolated from edible fruit seed was found to have potential for immunostimulatory and immunosuppressive activity. [Display omitted]</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2021.01.027</identifier><identifier>PMID: 33428960</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[Adjuvants, Immunologic - isolation & purification ; Adjuvants, Immunologic - pharmacology ; Adjuvants, Immunologic - therapeutic use ; Anaphylaxis ; Anaphylaxis - prevention & control ; Animals ; Anti-Allergic Agents - isolation & purification ; Anti-Allergic Agents - pharmacology ; Anti-Allergic Agents - therapeutic use ; Antibody titre ; Arthus reaction ; Arthus Reaction - prevention & control ; Blood Group Antigens ; Complement Inactivating Agents - isolation & purification ; Complement Inactivating Agents - pharmacology ; Complement Inactivating Agents - therapeutic use ; Drug Evaluation, Preclinical ; Hemagglutination - drug effects ; Humans ; Immunologic Factors - isolation & purification ; Immunologic Factors - pharmacology ; Immunologic Factors - therapeutic use ; Lectins - isolation & purification ; Lectins - pharmacology ; Lectins - therapeutic use ; Leukocytes - drug effects ; Lymphocyte Activation - drug effects ; Lysosomes - enzymology ; Macrophages - drug effects ; Phagocytosis ; Phagocytosis - drug effects ; Plants, Medicinal - chemistry ; Proliferation ; Rabbits ; Rats ; Rats, Wistar ; Seeds - chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Ziziphus - chemistry ; Zizyphus mauritiana seed Lectin (ZMSL)]]></subject><ispartof>International journal of biological macromolecules, 2021-02, Vol.171, p.389-397</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-cd56d397a0db2320c1648463e083137c16edf91aa8b82bfc3cf73d83459145d93</citedby><cites>FETCH-LOGICAL-c368t-cd56d397a0db2320c1648463e083137c16edf91aa8b82bfc3cf73d83459145d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813021000465$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33428960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butle, Ashwin B.</creatorcontrib><creatorcontrib>Talmale, Suhas A.</creatorcontrib><creatorcontrib>Jadhao, Vivek V.</creatorcontrib><creatorcontrib>Patil, Mandakini B.</creatorcontrib><creatorcontrib>Lambat, Trimurti L.</creatorcontrib><title>Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Anaphylaxis is a severe life-threatening allergic reaction and Arthus reaction is deposition of immune complex and complement system activation, so we hypothesized that if ZMSL can protect these severe allergic diseases. We have studied the effect of ZMSL on macrophages and Wistar albino rats and confirmed its protective effect against anaphylaxis and Arthus reaction. Results of this study suggest ZMSL have immunostimulatory and antiallergic activity.
ZMSL isolated from edible fruit seed was found to have potential for immunostimulatory and immunosuppressive activity. [Display omitted]</description><subject>Adjuvants, Immunologic - isolation & purification</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Anaphylaxis</subject><subject>Anaphylaxis - prevention & control</subject><subject>Animals</subject><subject>Anti-Allergic Agents - isolation & purification</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>Antibody titre</subject><subject>Arthus reaction</subject><subject>Arthus Reaction - prevention & control</subject><subject>Blood Group Antigens</subject><subject>Complement Inactivating Agents - isolation & purification</subject><subject>Complement Inactivating Agents - pharmacology</subject><subject>Complement Inactivating Agents - therapeutic use</subject><subject>Drug Evaluation, Preclinical</subject><subject>Hemagglutination - drug effects</subject><subject>Humans</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Lectins - isolation & purification</subject><subject>Lectins - pharmacology</subject><subject>Lectins - therapeutic use</subject><subject>Leukocytes - drug effects</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lysosomes - enzymology</subject><subject>Macrophages - drug effects</subject><subject>Phagocytosis</subject><subject>Phagocytosis - drug effects</subject><subject>Plants, Medicinal - chemistry</subject><subject>Proliferation</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seeds - chemistry</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Ziziphus - chemistry</subject><subject>Zizyphus mauritiana seed Lectin (ZMSL)</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJaLZJ_0LQMRdv9WHL8i0h5AsWemkuuQhZGjdaJGsjyYHtr6-WTXotjBAanlfDPAhdUrKmhIof27Xbji4GbdaMMLomtVj_Ba2o7IeGEMJP0IrQljaScnKGvuW8rV3RUfkVnXHeMjkIskLpKYRljrm4sHhdYtpjPdt6imu095B-O4N3sUBtaI_jhOf4Dh6_QoEUS3IBUiU8mOJmPKUYcAaw-UC-uD_73euScdBLcjU_a7zR4QKdTtpn-P5xn6Pn-7tft4_N5ufD0-3NpjFcyNIY2wnLh14TOzLOiKGila3gQCSnvK9PsNNAtZajZONkuJl6biVvu4G2nR34Obo6_rtL8W2BXFRw2YD3eoa4ZMXavmeCsK6tqDiiJsWcE0xqVzfTaa8oUQffaqs-fauDb0Vqsb4GLz9mLGMA-y_2KbgC10cA6qbvDpLKxsFswLpUnSkb3f9m_AU3AZbd</recordid><startdate>20210228</startdate><enddate>20210228</enddate><creator>Butle, Ashwin B.</creator><creator>Talmale, Suhas A.</creator><creator>Jadhao, Vivek V.</creator><creator>Patil, Mandakini B.</creator><creator>Lambat, Trimurti L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210228</creationdate><title>Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam</title><author>Butle, Ashwin B. ; Talmale, Suhas A. ; Jadhao, Vivek V. ; Patil, Mandakini B. ; Lambat, Trimurti L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-cd56d397a0db2320c1648463e083137c16edf91aa8b82bfc3cf73d83459145d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adjuvants, Immunologic - isolation & purification</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Anaphylaxis</topic><topic>Anaphylaxis - prevention & control</topic><topic>Animals</topic><topic>Anti-Allergic Agents - isolation & purification</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>Antibody titre</topic><topic>Arthus reaction</topic><topic>Arthus Reaction - prevention & control</topic><topic>Blood Group Antigens</topic><topic>Complement Inactivating Agents - isolation & purification</topic><topic>Complement Inactivating Agents - pharmacology</topic><topic>Complement Inactivating Agents - therapeutic use</topic><topic>Drug Evaluation, Preclinical</topic><topic>Hemagglutination - drug effects</topic><topic>Humans</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Lectins - isolation & purification</topic><topic>Lectins - pharmacology</topic><topic>Lectins - therapeutic use</topic><topic>Leukocytes - drug effects</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lysosomes - enzymology</topic><topic>Macrophages - drug effects</topic><topic>Phagocytosis</topic><topic>Phagocytosis - drug effects</topic><topic>Plants, Medicinal - chemistry</topic><topic>Proliferation</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seeds - chemistry</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Ziziphus - chemistry</topic><topic>Zizyphus mauritiana seed Lectin (ZMSL)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butle, Ashwin B.</creatorcontrib><creatorcontrib>Talmale, Suhas A.</creatorcontrib><creatorcontrib>Jadhao, Vivek V.</creatorcontrib><creatorcontrib>Patil, Mandakini B.</creatorcontrib><creatorcontrib>Lambat, Trimurti L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butle, Ashwin B.</au><au>Talmale, Suhas A.</au><au>Jadhao, Vivek V.</au><au>Patil, Mandakini B.</au><au>Lambat, Trimurti L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2021-02-28</date><risdate>2021</risdate><volume>171</volume><spage>389</spage><epage>397</epage><pages>389-397</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Anaphylaxis is a severe life-threatening allergic reaction and Arthus reaction is deposition of immune complex and complement system activation, so we hypothesized that if ZMSL can protect these severe allergic diseases. We have studied the effect of ZMSL on macrophages and Wistar albino rats and confirmed its protective effect against anaphylaxis and Arthus reaction. Results of this study suggest ZMSL have immunostimulatory and antiallergic activity.
ZMSL isolated from edible fruit seed was found to have potential for immunostimulatory and immunosuppressive activity. [Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33428960</pmid><doi>10.1016/j.ijbiomac.2021.01.027</doi><tpages>9</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - isolation & purification Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Anaphylaxis Anaphylaxis - prevention & control Animals Anti-Allergic Agents - isolation & purification Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Antibody titre Arthus reaction Arthus Reaction - prevention & control Blood Group Antigens Complement Inactivating Agents - isolation & purification Complement Inactivating Agents - pharmacology Complement Inactivating Agents - therapeutic use Drug Evaluation, Preclinical Hemagglutination - drug effects Humans Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Lectins - isolation & purification Lectins - pharmacology Lectins - therapeutic use Leukocytes - drug effects Lymphocyte Activation - drug effects Lysosomes - enzymology Macrophages - drug effects Phagocytosis Phagocytosis - drug effects Plants, Medicinal - chemistry Proliferation Rabbits Rats Rats, Wistar Seeds - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Ziziphus - chemistry Zizyphus mauritiana seed Lectin (ZMSL) |
| title | Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam |
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