Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice

•Age-related cognitive deficits and neuronal injury occurred in aged mice.•The gut microbiota in aged mice appeared to represent a proinflammatory phenotype.•Intestinal barrier and blood-brain barrier injuries were induced in aged mice.•LPS-activated TLR4 pathway contributed to age-related periphera...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Behavioural brain research 2021-03, Vol.402, p.113125-113125, Article 113125
Hauptverfasser:	Wu, Mei-Ling, Yang, Xue-Qin, Xue, Li, Duan, Wei, Du, Jun-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - immunology Aging - metabolism Animals Behavior, Animal - physiology Blood-Brain Barrier - immunology Blood-Brain Barrier - metabolism Blood-Brain Barrier - physiopathology Cognitive decline Cognitive Dysfunction - immunology Cognitive Dysfunction - metabolism Cognitive Dysfunction - physiopathology Dysbiosis - immunology Dysbiosis - metabolism Gastrointestinal Microbiome - physiology Inflammation Inflammation - immunology Inflammation - metabolism Intestinal Diseases - immunology Intestinal Diseases - metabolism Intestinal Diseases - physiopathology LPS/TLR4 Male Mice Mice, Inbred C57BL Microbiota-gut-brain axis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!