Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats
•Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in...
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creator | Ghalandari-Shamami, Mohadeseh Nourizade, Shahla Barati, Mehdi Yousefi, Behpour Pashayi, Mehrnush Ali Vafaei, Abbas Kokhaei, Parviz Rashidy-Pour, Ali |
description | •Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in control and stress rats.
Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period. |
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Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2020.147274</identifier><identifier>PMID: 33422526</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent stress ; Animals ; BDNF ; Carotenoids - pharmacology ; Crocin ; Dendrites - drug effects ; Dendritic remodeling ; Hippocampus - drug effects ; Male ; Memory - drug effects ; Memory - physiology ; Memory Disorders - drug therapy ; Memory Disorders - physiopathology ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Wistar ; Restraint, Physical - methods ; Spatial navigation ; Spatial Navigation - drug effects ; Stress, Psychological - drug therapy ; Stress, Psychological - physiopathology ; Voluntary exercise</subject><ispartof>Brain research, 2021-03, Vol.1754, p.147274-147274, Article 147274</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-120a5f87c131b2130e2b90809c90eef66518021f69171421e706ca43002d4bd93</citedby><cites>FETCH-LOGICAL-c368t-120a5f87c131b2130e2b90809c90eef66518021f69171421e706ca43002d4bd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2020.147274$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33422526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghalandari-Shamami, Mohadeseh</creatorcontrib><creatorcontrib>Nourizade, Shahla</creatorcontrib><creatorcontrib>Barati, Mehdi</creatorcontrib><creatorcontrib>Yousefi, Behpour</creatorcontrib><creatorcontrib>Pashayi, Mehrnush</creatorcontrib><creatorcontrib>Ali Vafaei, Abbas</creatorcontrib><creatorcontrib>Kokhaei, Parviz</creatorcontrib><creatorcontrib>Rashidy-Pour, Ali</creatorcontrib><title>Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>•Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in control and stress rats.
Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.</description><subject>Adolescent stress</subject><subject>Animals</subject><subject>BDNF</subject><subject>Carotenoids - pharmacology</subject><subject>Crocin</subject><subject>Dendrites - drug effects</subject><subject>Dendritic remodeling</subject><subject>Hippocampus - drug effects</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - physiopathology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical - methods</subject><subject>Spatial navigation</subject><subject>Spatial Navigation - drug effects</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - physiopathology</subject><subject>Voluntary exercise</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCIbgt_ofKRS5axnXWSG9WqBaRKXOBsTewJ9Spxgu2s4M_0t-Lttlw5zdeb9zTzGLsWsBUg9MfDto_oQ6S0lSBLs25kU79iG9E2stKyhtdsAwC6artOXbDLlA6lVKqDt-xCqVrKndQb9nj7m6L1iTgGx22crQ98iXSkkDm6eaRkS1qlXKQS98Gtlhz304I-TifQPPC0YPY48oBH_7Okc3hicxRc9NlbHilHtE-DQp8fiD_4ZZktFpqR728Ux0h4mqFbx8wnHIlHzOkdezPgmOj9c7xiP-5uv--_VPffPn_d39xXVuk2V0IC7oa2sUKJXgoFJPsOWuhsB0SD1jvRghSD7kQjaimoAW2xVgDS1b3r1BX7cOZd4vxrpZTN5Mvh44iB5jUZWTe63Qkt2gLVZ2h5VkqRBrNEP2H8YwSYkzfmYF68MSdvzNmbsnj9rLH2E7l_ay9mFMCnM4DKpUdP0STrKZR_-0g2Gzf7_2n8BWfEpUY</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ghalandari-Shamami, Mohadeseh</creator><creator>Nourizade, Shahla</creator><creator>Barati, Mehdi</creator><creator>Yousefi, Behpour</creator><creator>Pashayi, Mehrnush</creator><creator>Ali Vafaei, Abbas</creator><creator>Kokhaei, Parviz</creator><creator>Rashidy-Pour, Ali</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats</title><author>Ghalandari-Shamami, Mohadeseh ; Nourizade, Shahla ; Barati, Mehdi ; Yousefi, Behpour ; Pashayi, Mehrnush ; Ali Vafaei, Abbas ; Kokhaei, Parviz ; Rashidy-Pour, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-120a5f87c131b2130e2b90809c90eef66518021f69171421e706ca43002d4bd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent stress</topic><topic>Animals</topic><topic>BDNF</topic><topic>Carotenoids - pharmacology</topic><topic>Crocin</topic><topic>Dendrites - drug effects</topic><topic>Dendritic remodeling</topic><topic>Hippocampus - drug effects</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Memory Disorders - drug therapy</topic><topic>Memory Disorders - physiopathology</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Restraint, Physical - methods</topic><topic>Spatial navigation</topic><topic>Spatial Navigation - drug effects</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - physiopathology</topic><topic>Voluntary exercise</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghalandari-Shamami, Mohadeseh</creatorcontrib><creatorcontrib>Nourizade, Shahla</creatorcontrib><creatorcontrib>Barati, Mehdi</creatorcontrib><creatorcontrib>Yousefi, Behpour</creatorcontrib><creatorcontrib>Pashayi, Mehrnush</creatorcontrib><creatorcontrib>Ali Vafaei, Abbas</creatorcontrib><creatorcontrib>Kokhaei, Parviz</creatorcontrib><creatorcontrib>Rashidy-Pour, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghalandari-Shamami, Mohadeseh</au><au>Nourizade, Shahla</au><au>Barati, Mehdi</au><au>Yousefi, Behpour</au><au>Pashayi, Mehrnush</au><au>Ali Vafaei, Abbas</au><au>Kokhaei, Parviz</au><au>Rashidy-Pour, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>1754</volume><spage>147274</spage><epage>147274</epage><pages>147274-147274</pages><artnum>147274</artnum><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>•Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in control and stress rats.
Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33422526</pmid><doi>10.1016/j.brainres.2020.147274</doi><tpages>1</tpages></addata></record> |
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subjects | Adolescent stress Animals BDNF Carotenoids - pharmacology Crocin Dendrites - drug effects Dendritic remodeling Hippocampus - drug effects Male Memory - drug effects Memory - physiology Memory Disorders - drug therapy Memory Disorders - physiopathology Physical Conditioning, Animal - physiology Rats Rats, Wistar Restraint, Physical - methods Spatial navigation Spatial Navigation - drug effects Stress, Psychological - drug therapy Stress, Psychological - physiopathology Voluntary exercise |
title | Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats |
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