Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats

•Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in...

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Veröffentlicht in:Brain research 2021-03, Vol.1754, p.147274-147274, Article 147274
Hauptverfasser: Ghalandari-Shamami, Mohadeseh, Nourizade, Shahla, Barati, Mehdi, Yousefi, Behpour, Pashayi, Mehrnush, Ali Vafaei, Abbas, Kokhaei, Parviz, Rashidy-Pour, Ali
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container_title Brain research
container_volume 1754
creator Ghalandari-Shamami, Mohadeseh
Nourizade, Shahla
Barati, Mehdi
Yousefi, Behpour
Pashayi, Mehrnush
Ali Vafaei, Abbas
Kokhaei, Parviz
Rashidy-Pour, Ali
description •Adolescent stress induced learning and memory impairment in adulthood.•Adolescent stress causeddendritic retraction in CA3 pyramidal cells.•Wheel running and crocin recovered stress effects on learning and memory and dendritic morphology.•Wheel running and crocin enhanced BDNF in the CA3 region in control and stress rats. Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.
doi_str_mv 10.1016/j.brainres.2020.147274
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Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. 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Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.</description><subject>Adolescent stress</subject><subject>Animals</subject><subject>BDNF</subject><subject>Carotenoids - pharmacology</subject><subject>Crocin</subject><subject>Dendrites - drug effects</subject><subject>Dendritic remodeling</subject><subject>Hippocampus - drug effects</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - physiopathology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical - methods</subject><subject>Spatial navigation</subject><subject>Spatial Navigation - drug effects</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - physiopathology</subject><subject>Voluntary exercise</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCIbgt_ofKRS5axnXWSG9WqBaRKXOBsTewJ9Spxgu2s4M_0t-Lttlw5zdeb9zTzGLsWsBUg9MfDto_oQ6S0lSBLs25kU79iG9E2stKyhtdsAwC6artOXbDLlA6lVKqDt-xCqVrKndQb9nj7m6L1iTgGx22crQ98iXSkkDm6eaRkS1qlXKQS98Gtlhz304I-TifQPPC0YPY48oBH_7Okc3hicxRc9NlbHilHtE-DQp8fiD_4ZZktFpqR728Ux0h4mqFbx8wnHIlHzOkdezPgmOj9c7xiP-5uv--_VPffPn_d39xXVuk2V0IC7oa2sUKJXgoFJPsOWuhsB0SD1jvRghSD7kQjaimoAW2xVgDS1b3r1BX7cOZd4vxrpZTN5Mvh44iB5jUZWTe63Qkt2gLVZ2h5VkqRBrNEP2H8YwSYkzfmYF68MSdvzNmbsnj9rLH2E7l_ay9mFMCnM4DKpUdP0STrKZR_-0g2Gzf7_2n8BWfEpUY</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ghalandari-Shamami, Mohadeseh</creator><creator>Nourizade, Shahla</creator><creator>Barati, Mehdi</creator><creator>Yousefi, Behpour</creator><creator>Pashayi, Mehrnush</creator><creator>Ali Vafaei, Abbas</creator><creator>Kokhaei, Parviz</creator><creator>Rashidy-Pour, Ali</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats</title><author>Ghalandari-Shamami, Mohadeseh ; 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Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30–40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41–55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33422526</pmid><doi>10.1016/j.brainres.2020.147274</doi><tpages>1</tpages></addata></record>
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subjects Adolescent stress
Animals
BDNF
Carotenoids - pharmacology
Crocin
Dendrites - drug effects
Dendritic remodeling
Hippocampus - drug effects
Male
Memory - drug effects
Memory - physiology
Memory Disorders - drug therapy
Memory Disorders - physiopathology
Physical Conditioning, Animal - physiology
Rats
Rats, Wistar
Restraint, Physical - methods
Spatial navigation
Spatial Navigation - drug effects
Stress, Psychological - drug therapy
Stress, Psychological - physiopathology
Voluntary exercise
title Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats
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