Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis
Prompt administration of antibiotics is a critical component of open fracture treatment. Traditional antibiotic recommendations have been a first-generation cephalosporin for Gustilo Type-I and Type-II open fractures, with the addition of an aminoglycoside for Type-III fractures and penicillin for s...
Gespeichert in:
| Veröffentlicht in: | Journal of bone and joint surgery. American volume 2021-04, Vol.103 (7), p.609-617 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 617 |
|---|---|
| container_issue | 7 |
| container_start_page | 609 |
| container_title | Journal of bone and joint surgery. American volume |
| container_volume | 103 |
| creator | Lin, Carol A. O'Hara, Nathan N. Sprague, Sheila O'Toole, Robert V. Joshi, Manjari Harris, Anthony D. Warner, Stephen J. Johal, Herman Natoli, Roman M. Hagen, Jennifer E. Jeray, Kyle J. Fowler, Justin T. Phelps, Kevin D. Pilson, Holly T. Gitajn, I. Leah Bhandari, Mohit Slobogean, Gerard P. |
| description | Prompt administration of antibiotics is a critical component of open fracture treatment. Traditional antibiotic recommendations have been a first-generation cephalosporin for Gustilo Type-I and Type-II open fractures, with the addition of an aminoglycoside for Type-III fractures and penicillin for soil contamination. However, concerns over changing bacterial patterns and the side effects of aminoglycosides have led to interest in other regimens. The purpose of the present study was to describe the adherence to current prophylactic antibiotic guidelines.
We evaluated the antibiotic-prescribing practices of 24 centers in the U.S. and Canada that were participating in 2 randomized controlled trials of skin-preparation solutions for open fractures. A total of 1,234 patients were evaluated.
All patients received antibiotics on the day of admission. The most commonly prescribed antibiotic regimen was cefazolin monotherapy (53.6%). Among patients with Type-I and Type-II fractures, there was 61.1% compliance with cefazolin monotherapy. In contrast, only 17.2% of patients with Type-III fractures received the recommended cefazolin and aminoglycoside therapy, with an additional 6.7% receiving piperacillin/tazobactam.
There is moderate adherence to the traditional antibiotic treatment guidelines for Gustilo Type-I and Type-II fractures and low adherence for Type-III fractures. Given the divergence between current practice patterns and prior recommendations, high-quality studies are needed to determine the most appropriate prophylactic protocol. |
| doi_str_mv | 10.2106/JBJS.20.01229 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2476568417</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2476568417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3388-e807527c8c83a1d5babb7f1fdf51303a056a62275fe3dd33c3668dd0e83002803</originalsourceid><addsrcrecordid>eNo90E1P3DAQgGGroipb2iNX5COXbMee2DHHLQIKWgnUj7Pl2BNtIIm3dqKFf0-2Cz2NNHo10jyMnQpYSgH62933u19LCUsQUl58YAuhUBUCjT5iCwApigtU6ph9zvkRAMoSqk_sGLEUotR6wR7WccdXYUOJBk98jPwn-dj3NAQK_GZqA3XtQJk3MfH7LQ38Ojk_Ton4ahjbuo1j6_lDitvNS-ee2_yFfWxcl-nr2zxhf66vfl_-KNb3N7eXq3XhEY0pyEClZOWNN-hEULWr66oRTWiUQEAHSjstZaUawhAQPWptQgAyOH9lAE_Y-eHuNsW_E-XR9m321HVuoDhlK8tKK21KUc1pcUh9ijknauw2tb1LL1aA3SPaPaKVYP8hzv3Z2-mp7in8r9_V5qA8BLvYjZTyUzftKNkNuW7cWNg7a4mFnPlhBodivzL4CvWAe3c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476568417</pqid></control><display><type>article</type><title>Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Lin, Carol A. ; O'Hara, Nathan N. ; Sprague, Sheila ; O'Toole, Robert V. ; Joshi, Manjari ; Harris, Anthony D. ; Warner, Stephen J. ; Johal, Herman ; Natoli, Roman M. ; Hagen, Jennifer E. ; Jeray, Kyle J. ; Fowler, Justin T. ; Phelps, Kevin D. ; Pilson, Holly T. ; Gitajn, I. Leah ; Bhandari, Mohit ; Slobogean, Gerard P.</creator><creatorcontrib>Lin, Carol A. ; O'Hara, Nathan N. ; Sprague, Sheila ; O'Toole, Robert V. ; Joshi, Manjari ; Harris, Anthony D. ; Warner, Stephen J. ; Johal, Herman ; Natoli, Roman M. ; Hagen, Jennifer E. ; Jeray, Kyle J. ; Fowler, Justin T. ; Phelps, Kevin D. ; Pilson, Holly T. ; Gitajn, I. Leah ; Bhandari, Mohit ; Slobogean, Gerard P. ; the PREP-IT Investigators</creatorcontrib><description>Prompt administration of antibiotics is a critical component of open fracture treatment. Traditional antibiotic recommendations have been a first-generation cephalosporin for Gustilo Type-I and Type-II open fractures, with the addition of an aminoglycoside for Type-III fractures and penicillin for soil contamination. However, concerns over changing bacterial patterns and the side effects of aminoglycosides have led to interest in other regimens. The purpose of the present study was to describe the adherence to current prophylactic antibiotic guidelines.
We evaluated the antibiotic-prescribing practices of 24 centers in the U.S. and Canada that were participating in 2 randomized controlled trials of skin-preparation solutions for open fractures. A total of 1,234 patients were evaluated.
All patients received antibiotics on the day of admission. The most commonly prescribed antibiotic regimen was cefazolin monotherapy (53.6%). Among patients with Type-I and Type-II fractures, there was 61.1% compliance with cefazolin monotherapy. In contrast, only 17.2% of patients with Type-III fractures received the recommended cefazolin and aminoglycoside therapy, with an additional 6.7% receiving piperacillin/tazobactam.
There is moderate adherence to the traditional antibiotic treatment guidelines for Gustilo Type-I and Type-II fractures and low adherence for Type-III fractures. Given the divergence between current practice patterns and prior recommendations, high-quality studies are needed to determine the most appropriate prophylactic protocol.</description><identifier>ISSN: 0021-9355</identifier><identifier>EISSN: 1535-1386</identifier><identifier>DOI: 10.2106/JBJS.20.01229</identifier><identifier>PMID: 33411466</identifier><language>eng</language><publisher>United States: Journal of Bone and Joint Surgery, Inc</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Antibiotic Prophylaxis - standards ; Antibiotic Prophylaxis - statistics & numerical data ; Cefazolin - therapeutic use ; Drug Administration Schedule ; Female ; Fracture Fixation - adverse effects ; Fractures, Open - complications ; Fractures, Open - surgery ; Guideline Adherence - statistics & numerical data ; Humans ; Male ; Middle Aged ; Multicenter Studies as Topic ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - etiology ; Surgical Wound Infection - prevention & control ; Time Factors</subject><ispartof>Journal of bone and joint surgery. American volume, 2021-04, Vol.103 (7), p.609-617</ispartof><rights>Journal of Bone and Joint Surgery, Inc.</rights><rights>Copyright © 2021 by The Journal of Bone and Joint Surgery, Incorporated.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3388-e807527c8c83a1d5babb7f1fdf51303a056a62275fe3dd33c3668dd0e83002803</citedby><cites>FETCH-LOGICAL-c3388-e807527c8c83a1d5babb7f1fdf51303a056a62275fe3dd33c3668dd0e83002803</cites><orcidid>0000-0003-1466-8063 ; 0000-0002-5628-6584 ; 0000-0002-3603-3344 ; 0000-0003-0537-3474 ; 0000-0001-7093-8836 ; 0000-0003-2815-4581 ; 0000-0001-8649-7385 ; 0000-0001-9787-3219 ; 0000-0003-0643-534 ; 0000-0003-4418-9944 ; 0000-0002-4182-3244 ; 0000-0003-1762-4082 ; 0000-0003-2928-0950 ; 0000-0003-3633-323 ; 0000-0001-9023-262 ; 0000-0003-3556-9179 ; 0000-0002-9111-9239 ; 0000-0003-0643-534X ; 0000-0003-3633-323X ; 0000-0001-9023-262X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33411466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Carol A.</creatorcontrib><creatorcontrib>O'Hara, Nathan N.</creatorcontrib><creatorcontrib>Sprague, Sheila</creatorcontrib><creatorcontrib>O'Toole, Robert V.</creatorcontrib><creatorcontrib>Joshi, Manjari</creatorcontrib><creatorcontrib>Harris, Anthony D.</creatorcontrib><creatorcontrib>Warner, Stephen J.</creatorcontrib><creatorcontrib>Johal, Herman</creatorcontrib><creatorcontrib>Natoli, Roman M.</creatorcontrib><creatorcontrib>Hagen, Jennifer E.</creatorcontrib><creatorcontrib>Jeray, Kyle J.</creatorcontrib><creatorcontrib>Fowler, Justin T.</creatorcontrib><creatorcontrib>Phelps, Kevin D.</creatorcontrib><creatorcontrib>Pilson, Holly T.</creatorcontrib><creatorcontrib>Gitajn, I. Leah</creatorcontrib><creatorcontrib>Bhandari, Mohit</creatorcontrib><creatorcontrib>Slobogean, Gerard P.</creatorcontrib><creatorcontrib>the PREP-IT Investigators</creatorcontrib><title>Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis</title><title>Journal of bone and joint surgery. American volume</title><addtitle>J Bone Joint Surg Am</addtitle><description>Prompt administration of antibiotics is a critical component of open fracture treatment. Traditional antibiotic recommendations have been a first-generation cephalosporin for Gustilo Type-I and Type-II open fractures, with the addition of an aminoglycoside for Type-III fractures and penicillin for soil contamination. However, concerns over changing bacterial patterns and the side effects of aminoglycosides have led to interest in other regimens. The purpose of the present study was to describe the adherence to current prophylactic antibiotic guidelines.
We evaluated the antibiotic-prescribing practices of 24 centers in the U.S. and Canada that were participating in 2 randomized controlled trials of skin-preparation solutions for open fractures. A total of 1,234 patients were evaluated.
All patients received antibiotics on the day of admission. The most commonly prescribed antibiotic regimen was cefazolin monotherapy (53.6%). Among patients with Type-I and Type-II fractures, there was 61.1% compliance with cefazolin monotherapy. In contrast, only 17.2% of patients with Type-III fractures received the recommended cefazolin and aminoglycoside therapy, with an additional 6.7% receiving piperacillin/tazobactam.
There is moderate adherence to the traditional antibiotic treatment guidelines for Gustilo Type-I and Type-II fractures and low adherence for Type-III fractures. Given the divergence between current practice patterns and prior recommendations, high-quality studies are needed to determine the most appropriate prophylactic protocol.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic Prophylaxis - standards</subject><subject>Antibiotic Prophylaxis - statistics & numerical data</subject><subject>Cefazolin - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fracture Fixation - adverse effects</subject><subject>Fractures, Open - complications</subject><subject>Fractures, Open - surgery</subject><subject>Guideline Adherence - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multicenter Studies as Topic</subject><subject>Practice Guidelines as Topic</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - etiology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Time Factors</subject><issn>0021-9355</issn><issn>1535-1386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1P3DAQgGGroipb2iNX5COXbMee2DHHLQIKWgnUj7Pl2BNtIIm3dqKFf0-2Cz2NNHo10jyMnQpYSgH62933u19LCUsQUl58YAuhUBUCjT5iCwApigtU6ph9zvkRAMoSqk_sGLEUotR6wR7WccdXYUOJBk98jPwn-dj3NAQK_GZqA3XtQJk3MfH7LQ38Ojk_Ton4ahjbuo1j6_lDitvNS-ee2_yFfWxcl-nr2zxhf66vfl_-KNb3N7eXq3XhEY0pyEClZOWNN-hEULWr66oRTWiUQEAHSjstZaUawhAQPWptQgAyOH9lAE_Y-eHuNsW_E-XR9m321HVuoDhlK8tKK21KUc1pcUh9ijknauw2tb1LL1aA3SPaPaKVYP8hzv3Z2-mp7in8r9_V5qA8BLvYjZTyUzftKNkNuW7cWNg7a4mFnPlhBodivzL4CvWAe3c</recordid><startdate>20210407</startdate><enddate>20210407</enddate><creator>Lin, Carol A.</creator><creator>O'Hara, Nathan N.</creator><creator>Sprague, Sheila</creator><creator>O'Toole, Robert V.</creator><creator>Joshi, Manjari</creator><creator>Harris, Anthony D.</creator><creator>Warner, Stephen J.</creator><creator>Johal, Herman</creator><creator>Natoli, Roman M.</creator><creator>Hagen, Jennifer E.</creator><creator>Jeray, Kyle J.</creator><creator>Fowler, Justin T.</creator><creator>Phelps, Kevin D.</creator><creator>Pilson, Holly T.</creator><creator>Gitajn, I. Leah</creator><creator>Bhandari, Mohit</creator><creator>Slobogean, Gerard P.</creator><general>Journal of Bone and Joint Surgery, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1466-8063</orcidid><orcidid>https://orcid.org/0000-0002-5628-6584</orcidid><orcidid>https://orcid.org/0000-0002-3603-3344</orcidid><orcidid>https://orcid.org/0000-0003-0537-3474</orcidid><orcidid>https://orcid.org/0000-0001-7093-8836</orcidid><orcidid>https://orcid.org/0000-0003-2815-4581</orcidid><orcidid>https://orcid.org/0000-0001-8649-7385</orcidid><orcidid>https://orcid.org/0000-0001-9787-3219</orcidid><orcidid>https://orcid.org/0000-0003-0643-534</orcidid><orcidid>https://orcid.org/0000-0003-4418-9944</orcidid><orcidid>https://orcid.org/0000-0002-4182-3244</orcidid><orcidid>https://orcid.org/0000-0003-1762-4082</orcidid><orcidid>https://orcid.org/0000-0003-2928-0950</orcidid><orcidid>https://orcid.org/0000-0003-3633-323</orcidid><orcidid>https://orcid.org/0000-0001-9023-262</orcidid><orcidid>https://orcid.org/0000-0003-3556-9179</orcidid><orcidid>https://orcid.org/0000-0002-9111-9239</orcidid><orcidid>https://orcid.org/0000-0003-0643-534X</orcidid><orcidid>https://orcid.org/0000-0003-3633-323X</orcidid><orcidid>https://orcid.org/0000-0001-9023-262X</orcidid></search><sort><creationdate>20210407</creationdate><title>Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis</title><author>Lin, Carol A. ; O'Hara, Nathan N. ; Sprague, Sheila ; O'Toole, Robert V. ; Joshi, Manjari ; Harris, Anthony D. ; Warner, Stephen J. ; Johal, Herman ; Natoli, Roman M. ; Hagen, Jennifer E. ; Jeray, Kyle J. ; Fowler, Justin T. ; Phelps, Kevin D. ; Pilson, Holly T. ; Gitajn, I. Leah ; Bhandari, Mohit ; Slobogean, Gerard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3388-e807527c8c83a1d5babb7f1fdf51303a056a62275fe3dd33c3668dd0e83002803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic Prophylaxis - standards</topic><topic>Antibiotic Prophylaxis - statistics & numerical data</topic><topic>Cefazolin - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fracture Fixation - adverse effects</topic><topic>Fractures, Open - complications</topic><topic>Fractures, Open - surgery</topic><topic>Guideline Adherence - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multicenter Studies as Topic</topic><topic>Practice Guidelines as Topic</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - etiology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Carol A.</creatorcontrib><creatorcontrib>O'Hara, Nathan N.</creatorcontrib><creatorcontrib>Sprague, Sheila</creatorcontrib><creatorcontrib>O'Toole, Robert V.</creatorcontrib><creatorcontrib>Joshi, Manjari</creatorcontrib><creatorcontrib>Harris, Anthony D.</creatorcontrib><creatorcontrib>Warner, Stephen J.</creatorcontrib><creatorcontrib>Johal, Herman</creatorcontrib><creatorcontrib>Natoli, Roman M.</creatorcontrib><creatorcontrib>Hagen, Jennifer E.</creatorcontrib><creatorcontrib>Jeray, Kyle J.</creatorcontrib><creatorcontrib>Fowler, Justin T.</creatorcontrib><creatorcontrib>Phelps, Kevin D.</creatorcontrib><creatorcontrib>Pilson, Holly T.</creatorcontrib><creatorcontrib>Gitajn, I. Leah</creatorcontrib><creatorcontrib>Bhandari, Mohit</creatorcontrib><creatorcontrib>Slobogean, Gerard P.</creatorcontrib><creatorcontrib>the PREP-IT Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and joint surgery. American volume</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Carol A.</au><au>O'Hara, Nathan N.</au><au>Sprague, Sheila</au><au>O'Toole, Robert V.</au><au>Joshi, Manjari</au><au>Harris, Anthony D.</au><au>Warner, Stephen J.</au><au>Johal, Herman</au><au>Natoli, Roman M.</au><au>Hagen, Jennifer E.</au><au>Jeray, Kyle J.</au><au>Fowler, Justin T.</au><au>Phelps, Kevin D.</au><au>Pilson, Holly T.</au><au>Gitajn, I. Leah</au><au>Bhandari, Mohit</au><au>Slobogean, Gerard P.</au><aucorp>the PREP-IT Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis</atitle><jtitle>Journal of bone and joint surgery. American volume</jtitle><addtitle>J Bone Joint Surg Am</addtitle><date>2021-04-07</date><risdate>2021</risdate><volume>103</volume><issue>7</issue><spage>609</spage><epage>617</epage><pages>609-617</pages><issn>0021-9355</issn><eissn>1535-1386</eissn><abstract>Prompt administration of antibiotics is a critical component of open fracture treatment. Traditional antibiotic recommendations have been a first-generation cephalosporin for Gustilo Type-I and Type-II open fractures, with the addition of an aminoglycoside for Type-III fractures and penicillin for soil contamination. However, concerns over changing bacterial patterns and the side effects of aminoglycosides have led to interest in other regimens. The purpose of the present study was to describe the adherence to current prophylactic antibiotic guidelines.
We evaluated the antibiotic-prescribing practices of 24 centers in the U.S. and Canada that were participating in 2 randomized controlled trials of skin-preparation solutions for open fractures. A total of 1,234 patients were evaluated.
All patients received antibiotics on the day of admission. The most commonly prescribed antibiotic regimen was cefazolin monotherapy (53.6%). Among patients with Type-I and Type-II fractures, there was 61.1% compliance with cefazolin monotherapy. In contrast, only 17.2% of patients with Type-III fractures received the recommended cefazolin and aminoglycoside therapy, with an additional 6.7% receiving piperacillin/tazobactam.
There is moderate adherence to the traditional antibiotic treatment guidelines for Gustilo Type-I and Type-II fractures and low adherence for Type-III fractures. Given the divergence between current practice patterns and prior recommendations, high-quality studies are needed to determine the most appropriate prophylactic protocol.</abstract><cop>United States</cop><pub>Journal of Bone and Joint Surgery, Inc</pub><pmid>33411466</pmid><doi>10.2106/JBJS.20.01229</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1466-8063</orcidid><orcidid>https://orcid.org/0000-0002-5628-6584</orcidid><orcidid>https://orcid.org/0000-0002-3603-3344</orcidid><orcidid>https://orcid.org/0000-0003-0537-3474</orcidid><orcidid>https://orcid.org/0000-0001-7093-8836</orcidid><orcidid>https://orcid.org/0000-0003-2815-4581</orcidid><orcidid>https://orcid.org/0000-0001-8649-7385</orcidid><orcidid>https://orcid.org/0000-0001-9787-3219</orcidid><orcidid>https://orcid.org/0000-0003-0643-534</orcidid><orcidid>https://orcid.org/0000-0003-4418-9944</orcidid><orcidid>https://orcid.org/0000-0002-4182-3244</orcidid><orcidid>https://orcid.org/0000-0003-1762-4082</orcidid><orcidid>https://orcid.org/0000-0003-2928-0950</orcidid><orcidid>https://orcid.org/0000-0003-3633-323</orcidid><orcidid>https://orcid.org/0000-0001-9023-262</orcidid><orcidid>https://orcid.org/0000-0003-3556-9179</orcidid><orcidid>https://orcid.org/0000-0002-9111-9239</orcidid><orcidid>https://orcid.org/0000-0003-0643-534X</orcidid><orcidid>https://orcid.org/0000-0003-3633-323X</orcidid><orcidid>https://orcid.org/0000-0001-9023-262X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9355 |
| ispartof | Journal of bone and joint surgery. American volume, 2021-04, Vol.103 (7), p.609-617 |
| issn | 0021-9355 1535-1386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2476568417 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - standards Antibiotic Prophylaxis - statistics & numerical data Cefazolin - therapeutic use Drug Administration Schedule Female Fracture Fixation - adverse effects Fractures, Open - complications Fractures, Open - surgery Guideline Adherence - statistics & numerical data Humans Male Middle Aged Multicenter Studies as Topic Practice Guidelines as Topic Randomized Controlled Trials as Topic Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Surgical Wound Infection - prevention & control Time Factors |
| title | Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T14%3A42%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20Adherence%20to%20Recommended%20Guidelines%20for%20Open%20Fracture%20Antibiotic%20Prophylaxis&rft.jtitle=Journal%20of%20bone%20and%20joint%20surgery.%20American%20volume&rft.au=Lin,%20Carol%20A.&rft.aucorp=the%20PREP-IT%20Investigators&rft.date=2021-04-07&rft.volume=103&rft.issue=7&rft.spage=609&rft.epage=617&rft.pages=609-617&rft.issn=0021-9355&rft.eissn=1535-1386&rft_id=info:doi/10.2106/JBJS.20.01229&rft_dat=%3Cproquest_cross%3E2476568417%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476568417&rft_id=info:pmid/33411466&rfr_iscdi=true |