Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease

•Treatment with G-Rg1 can ameliorate liver injury in a mouse model of alcoholic hepatitis (AH).•G-Rg1 blocks the up-regulation of CYP2E1 and generation of ROS following alcohol consumption.•G-Rg1 inhibits NLRP3 inflammasome activation and inflammatory cytokine production in AH.•Identified drugable p...

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Veröffentlicht in:	International immunopharmacology 2021-03, Vol.92, p.107327-107327, Article 107327
Hauptverfasser:	Yang, Cheng, He, Xiaoqing, Zhao, Jinqiu, Huang, Wenxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Alcoholic hepatitis Apoptosis Aspartate aminotransferase Bilirubin Caspase-1 CYP2E1 Cytochrome Cytochromes Cytokines Disease Ethanol Fatty liver Ginsenoside Rg1 Ginsenosides Hepatitis Histology Inflammasomes Liver Liver diseases Medical treatment Mitochondria NLRP3 Reactive oxygen species Serum levels Steatosis Transaminase
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