Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan
Circulation of the dominant sub-genotype VII.2 of Avian Orthoavulavirus-1 (AOAV-1) is affecting multiple poultry and non-poultry avian species and causing significant economic losses to the poultry industry worldwide. In countries where ND is endemic, continuous monitoring and characterization of fi...
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| creator | Wajid, Abdul Mayahi, Vafa Yin, Renfu Ain, Quratul Mohiuddin, Ayesha Khalid, Farah Rehim, Asif Manan, Abdul Baksh, Muqadas |
| description | Circulation of the dominant sub-genotype VII.2 of Avian Orthoavulavirus-1 (AOAV-1) is affecting multiple poultry and non-poultry avian species and causing significant economic losses to the poultry industry worldwide. In countries where ND is endemic, continuous monitoring and characterization of field strains are necessary. In this study, genetic characteristics of eleven AOAV-1 strains were analyzed isolated from wild birds including parakeets (
n
= 3), lovebird parrot (
n
= 1), pheasant (
n
= 1), peacock (
n
= 1), and backyard chickens (
n
= 5) during 2015–2016. Genetic characterization (genome size [15,192 nucleotides], the presence of typical cleavage site [
112−
RRQKRF
−117
]) and biological assessment (HA log 2
7
to 2
9
and intracerebral pathogenicity index [ICPI] value ranging from 1.50 to 1.86) showed virulent AOAV-1. Phylogenetic analysis showed that the studied isolates belonged to sub-genotype VII.2 and genetically very closely related (> 98.9%) to viruses repeatedly isolated (2011–2018) from commercial poultry. These findings provide evidence for the existence of epidemiological links between poultry and wild bird species in the region where the disease is prevalent. The deduced amino acid analysis revealed several substitutions in critical domains of fusion and hemagglutinin-neuraminidase genes. The pathogenesis and transmission potential of wild bird-origin AOAV-1 strain (AW-Pht/2015) was evaluated in 21-day-old chickens that showed the strain was highly virulent causing clinical signs and killed all chickens. High viral loads were detected in different organs of the infected chickens correlating with the severity of lesions developed. The continuous monitoring of AOAV-1 isolates in different species of birds will improve our knowledge of the evolution of these viruses, thereby preventing possible panzootic. |
| doi_str_mv | 10.1007/s11250-020-02497-y |
| format | Article |
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n
= 3), lovebird parrot (
n
= 1), pheasant (
n
= 1), peacock (
n
= 1), and backyard chickens (
n
= 5) during 2015–2016. Genetic characterization (genome size [15,192 nucleotides], the presence of typical cleavage site [
112−
RRQKRF
−117
]) and biological assessment (HA log 2
7
to 2
9
and intracerebral pathogenicity index [ICPI] value ranging from 1.50 to 1.86) showed virulent AOAV-1. Phylogenetic analysis showed that the studied isolates belonged to sub-genotype VII.2 and genetically very closely related (> 98.9%) to viruses repeatedly isolated (2011–2018) from commercial poultry. These findings provide evidence for the existence of epidemiological links between poultry and wild bird species in the region where the disease is prevalent. The deduced amino acid analysis revealed several substitutions in critical domains of fusion and hemagglutinin-neuraminidase genes. The pathogenesis and transmission potential of wild bird-origin AOAV-1 strain (AW-Pht/2015) was evaluated in 21-day-old chickens that showed the strain was highly virulent causing clinical signs and killed all chickens. High viral loads were detected in different organs of the infected chickens correlating with the severity of lesions developed. The continuous monitoring of AOAV-1 isolates in different species of birds will improve our knowledge of the evolution of these viruses, thereby preventing possible panzootic.</description><identifier>ISSN: 0049-4747</identifier><identifier>EISSN: 1573-7438</identifier><identifier>DOI: 10.1007/s11250-020-02497-y</identifier><identifier>PMID: 33415381</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Animals, Wild ; Avulavirus - genetics ; Avulavirus - physiology ; Avulavirus Infections - veterinary ; Avulavirus Infections - virology ; Biomedical and Life Sciences ; Bird Diseases - virology ; Birds ; Chickens ; Economic impact ; Epidemiology ; Exo-a-sialidase ; Galliformes ; Genome, Viral ; Genomes ; Genotypes ; Hemagglutinins ; Life Sciences ; Monitoring ; Nucleotides ; Organs ; Pakistan ; Parrots ; Pathogenesis ; Pathogenicity ; Pathogens ; Phylogeny ; Poultry ; Poultry Diseases - virology ; Regular Articles ; Species ; Strains (organisms) ; Veterinary Medicine/Veterinary Science ; Viral Fusion Proteins - analysis ; Virulence ; Viruses ; Zoology</subject><ispartof>Tropical animal health and production, 2021-12, Vol.53 (1), p.90-90, Article 90</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-697147d9683d95175ddd223911136ce019195f37c57274ca53172c564cc6c8f03</citedby><cites>FETCH-LOGICAL-c403t-697147d9683d95175ddd223911136ce019195f37c57274ca53172c564cc6c8f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11250-020-02497-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11250-020-02497-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33415381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wajid, Abdul</creatorcontrib><creatorcontrib>Mayahi, Vafa</creatorcontrib><creatorcontrib>Yin, Renfu</creatorcontrib><creatorcontrib>Ain, Quratul</creatorcontrib><creatorcontrib>Mohiuddin, Ayesha</creatorcontrib><creatorcontrib>Khalid, Farah</creatorcontrib><creatorcontrib>Rehim, Asif</creatorcontrib><creatorcontrib>Manan, Abdul</creatorcontrib><creatorcontrib>Baksh, Muqadas</creatorcontrib><title>Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan</title><title>Tropical animal health and production</title><addtitle>Trop Anim Health Prod</addtitle><addtitle>Trop Anim Health Prod</addtitle><description>Circulation of the dominant sub-genotype VII.2 of Avian Orthoavulavirus-1 (AOAV-1) is affecting multiple poultry and non-poultry avian species and causing significant economic losses to the poultry industry worldwide. In countries where ND is endemic, continuous monitoring and characterization of field strains are necessary. In this study, genetic characteristics of eleven AOAV-1 strains were analyzed isolated from wild birds including parakeets (
n
= 3), lovebird parrot (
n
= 1), pheasant (
n
= 1), peacock (
n
= 1), and backyard chickens (
n
= 5) during 2015–2016. Genetic characterization (genome size [15,192 nucleotides], the presence of typical cleavage site [
112−
RRQKRF
−117
]) and biological assessment (HA log 2
7
to 2
9
and intracerebral pathogenicity index [ICPI] value ranging from 1.50 to 1.86) showed virulent AOAV-1. Phylogenetic analysis showed that the studied isolates belonged to sub-genotype VII.2 and genetically very closely related (> 98.9%) to viruses repeatedly isolated (2011–2018) from commercial poultry. These findings provide evidence for the existence of epidemiological links between poultry and wild bird species in the region where the disease is prevalent. The deduced amino acid analysis revealed several substitutions in critical domains of fusion and hemagglutinin-neuraminidase genes. The pathogenesis and transmission potential of wild bird-origin AOAV-1 strain (AW-Pht/2015) was evaluated in 21-day-old chickens that showed the strain was highly virulent causing clinical signs and killed all chickens. High viral loads were detected in different organs of the infected chickens correlating with the severity of lesions developed. The continuous monitoring of AOAV-1 isolates in different species of birds will improve our knowledge of the evolution of these viruses, thereby preventing possible panzootic.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Animals, Wild</subject><subject>Avulavirus - genetics</subject><subject>Avulavirus - physiology</subject><subject>Avulavirus Infections - veterinary</subject><subject>Avulavirus Infections - virology</subject><subject>Biomedical and Life Sciences</subject><subject>Bird Diseases - virology</subject><subject>Birds</subject><subject>Chickens</subject><subject>Economic impact</subject><subject>Epidemiology</subject><subject>Exo-a-sialidase</subject><subject>Galliformes</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Genotypes</subject><subject>Hemagglutinins</subject><subject>Life Sciences</subject><subject>Monitoring</subject><subject>Nucleotides</subject><subject>Organs</subject><subject>Pakistan</subject><subject>Parrots</subject><subject>Pathogenesis</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Phylogeny</subject><subject>Poultry</subject><subject>Poultry Diseases - virology</subject><subject>Regular Articles</subject><subject>Species</subject><subject>Strains (organisms)</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Viral Fusion Proteins - analysis</subject><subject>Virulence</subject><subject>Viruses</subject><subject>Zoology</subject><issn>0049-4747</issn><issn>1573-7438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9uFSEchYnR2Gv1BVwYEjduRvnxd1g2jVaTJnWha0KBaellhivM3OY-hO8s16mauOiCsOA73yE5CL0G8h4IUR8qABWkI_R4uFbd4QnagFCsU5z1T9GGEK47rrg6QS9qvSOkxXr5HJ0wxkGwHjbo50WY8hgdtpPH1zGnfBOdTdjd2mLdHEqsc3QV5wGf7aOd8FWZb7PdL8nuY1lqB7jOxcap4lhzsnPweCh5xOOS5rhLAd_HdDQXX9cO67YHW3xriG4bjrkJf7Xb1mOnl-jZYFMNrx7uU_T908dv55-7y6uLL-dnl53jhM2d1Aq48lr2zGsBSnjvKWUaAJh0gYAGLQamnFBUcWcFA0WdkNw56fqBsFP0bvXuSv6xhDqbMVYXUrJTyEs1lCsppJKaNfTtf-hdXsrUfmeooJqA1EAepZqLcC4obxRdKVdyrSUMZlfiaMvBADHHSc06qWmTmt-TmkMLvXlQL9dj8H8jfzZsAFuB2p6mm1D-dT-i_QXvgqxQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Wajid, Abdul</creator><creator>Mayahi, Vafa</creator><creator>Yin, Renfu</creator><creator>Ain, Quratul</creator><creator>Mohiuddin, Ayesha</creator><creator>Khalid, Farah</creator><creator>Rehim, Asif</creator><creator>Manan, Abdul</creator><creator>Baksh, Muqadas</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan</title><author>Wajid, Abdul ; Mayahi, Vafa ; Yin, Renfu ; Ain, Quratul ; Mohiuddin, Ayesha ; Khalid, Farah ; Rehim, Asif ; Manan, Abdul ; Baksh, Muqadas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-697147d9683d95175ddd223911136ce019195f37c57274ca53172c564cc6c8f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Animals, Wild</topic><topic>Avulavirus - genetics</topic><topic>Avulavirus - physiology</topic><topic>Avulavirus Infections - veterinary</topic><topic>Avulavirus Infections - virology</topic><topic>Biomedical and Life Sciences</topic><topic>Bird Diseases - virology</topic><topic>Birds</topic><topic>Chickens</topic><topic>Economic impact</topic><topic>Epidemiology</topic><topic>Exo-a-sialidase</topic><topic>Galliformes</topic><topic>Genome, Viral</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Hemagglutinins</topic><topic>Life Sciences</topic><topic>Monitoring</topic><topic>Nucleotides</topic><topic>Organs</topic><topic>Pakistan</topic><topic>Parrots</topic><topic>Pathogenesis</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Phylogeny</topic><topic>Poultry</topic><topic>Poultry Diseases - virology</topic><topic>Regular Articles</topic><topic>Species</topic><topic>Strains (organisms)</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Viral Fusion Proteins - analysis</topic><topic>Virulence</topic><topic>Viruses</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wajid, Abdul</creatorcontrib><creatorcontrib>Mayahi, Vafa</creatorcontrib><creatorcontrib>Yin, Renfu</creatorcontrib><creatorcontrib>Ain, Quratul</creatorcontrib><creatorcontrib>Mohiuddin, Ayesha</creatorcontrib><creatorcontrib>Khalid, Farah</creatorcontrib><creatorcontrib>Rehim, Asif</creatorcontrib><creatorcontrib>Manan, Abdul</creatorcontrib><creatorcontrib>Baksh, Muqadas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical animal health and production</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wajid, Abdul</au><au>Mayahi, Vafa</au><au>Yin, Renfu</au><au>Ain, Quratul</au><au>Mohiuddin, Ayesha</au><au>Khalid, Farah</au><au>Rehim, Asif</au><au>Manan, Abdul</au><au>Baksh, Muqadas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan</atitle><jtitle>Tropical animal health and production</jtitle><stitle>Trop Anim Health Prod</stitle><addtitle>Trop Anim Health Prod</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>53</volume><issue>1</issue><spage>90</spage><epage>90</epage><pages>90-90</pages><artnum>90</artnum><issn>0049-4747</issn><eissn>1573-7438</eissn><abstract>Circulation of the dominant sub-genotype VII.2 of Avian Orthoavulavirus-1 (AOAV-1) is affecting multiple poultry and non-poultry avian species and causing significant economic losses to the poultry industry worldwide. In countries where ND is endemic, continuous monitoring and characterization of field strains are necessary. In this study, genetic characteristics of eleven AOAV-1 strains were analyzed isolated from wild birds including parakeets (
n
= 3), lovebird parrot (
n
= 1), pheasant (
n
= 1), peacock (
n
= 1), and backyard chickens (
n
= 5) during 2015–2016. Genetic characterization (genome size [15,192 nucleotides], the presence of typical cleavage site [
112−
RRQKRF
−117
]) and biological assessment (HA log 2
7
to 2
9
and intracerebral pathogenicity index [ICPI] value ranging from 1.50 to 1.86) showed virulent AOAV-1. Phylogenetic analysis showed that the studied isolates belonged to sub-genotype VII.2 and genetically very closely related (> 98.9%) to viruses repeatedly isolated (2011–2018) from commercial poultry. These findings provide evidence for the existence of epidemiological links between poultry and wild bird species in the region where the disease is prevalent. The deduced amino acid analysis revealed several substitutions in critical domains of fusion and hemagglutinin-neuraminidase genes. The pathogenesis and transmission potential of wild bird-origin AOAV-1 strain (AW-Pht/2015) was evaluated in 21-day-old chickens that showed the strain was highly virulent causing clinical signs and killed all chickens. High viral loads were detected in different organs of the infected chickens correlating with the severity of lesions developed. The continuous monitoring of AOAV-1 isolates in different species of birds will improve our knowledge of the evolution of these viruses, thereby preventing possible panzootic.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33415381</pmid><doi>10.1007/s11250-020-02497-y</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Amino acids Animals Animals, Wild Avulavirus - genetics Avulavirus - physiology Avulavirus Infections - veterinary Avulavirus Infections - virology Biomedical and Life Sciences Bird Diseases - virology Birds Chickens Economic impact Epidemiology Exo-a-sialidase Galliformes Genome, Viral Genomes Genotypes Hemagglutinins Life Sciences Monitoring Nucleotides Organs Pakistan Parrots Pathogenesis Pathogenicity Pathogens Phylogeny Poultry Poultry Diseases - virology Regular Articles Species Strains (organisms) Veterinary Medicine/Veterinary Science Viral Fusion Proteins - analysis Virulence Viruses Zoology |
| title | Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan |
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