Covert strokes prior to Alzheimer’s disease onset accelerate peri-lesional pathology but not cognitive deficits in an inducible APP mouse model

•T2 MRI confirmed the presence of two small lesions in animals receiving ET-1.•Focal subclinical ischemia resulted in a localized increase in amyloid load.•ET-1 increased microglial activation but not astrogliosis in APPsi-tTA animals.•APP expression drove behavioural deficits.•Covert strokes prior...

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