Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma
Purpose To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock. Materials and Methods Seven different types of mixtures were evaluated: cisplatin powder and lipiod...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2021-05, Vol.44 (5), p.766-773 |
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| creator | Tanaka, Toshihiro Iwamoto, Hideki Fujihara, Mitsuteru Nishiofuku, Hideyuki Masada, Tetsuya Suzuki, Hiroyuki Koga, Hironori Torimura, Takuji Kichikawa, Kimihiko |
| description | Purpose
To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock.
Materials and Methods
Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion).
Result
The percentages of water-in-oil were 98.08 ± 0.27% in the emulsion formed by the device, while 70.3 ± 4.63% in the emulsion formed by a 3-way stopcock (
P
= 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 ± 0.38% and 98.70 ± 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 ± 19, 244 ± 24 and 478 ± 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 ± 8 min (
P
= 0.046–0.050). Suspension showed the longest release time; however, the viscosity was lowest.
Conclusion
The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device. |
| doi_str_mv | 10.1007/s00270-020-02757-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2476566837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2476566837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-39f28830192a5f39a16f4d617c29f791a534d243fd1258aaf7a7714e8a977493</originalsourceid><addsrcrecordid>eNp9kctO3DAUhq2qVRmgL9BFZYkNm7S-xskSTYeLNAgWs2BnHRK7GDlxaifQeRWeFoehRWLRheWFv__30fkQ-krJd0qI-pEIYYoUhM1HSVWwD2hBBWcFqcqbj2hBqBIFlZLuof2U7gmhsmLyM9rjXFApqFqgp5W1roFmi4PFgM88pIQvTXcboTd41U0-uRkYXejxT_PgGoPHgE9D7PCl-zNO0czJpUuDz1CPr8NjayJ-dOMdXrvBhTZ4nLObXJggjiY68HhzZyIMW2xDxOdmgDE0xvvJQ8RLiI3rQweH6JMFn8yX1_sAbU5Xm-V5sb46u1ierIuGKzkWvLasqjihNQNpeQ20tKItqWpYbVVNQXLRMsFtS5msAKwCpagwFdRKiZofoONd7RDD78mkUXcuzdPkBYQpaSZUKcuy4iqjR-_Q-zDFPg-nmaSy5nmpM8V2VBNDStFYPUTXQdxqSvQsTu_E6SxOv4jTLIe-vVZPt51p_0X-msoA3wEpP_W_THz7-z-1z3wwpCM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2515931547</pqid></control><display><type>article</type><title>Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma</title><source>SpringerLink Journals</source><creator>Tanaka, Toshihiro ; Iwamoto, Hideki ; Fujihara, Mitsuteru ; Nishiofuku, Hideyuki ; Masada, Tetsuya ; Suzuki, Hiroyuki ; Koga, Hironori ; Torimura, Takuji ; Kichikawa, Kimihiko</creator><creatorcontrib>Tanaka, Toshihiro ; Iwamoto, Hideki ; Fujihara, Mitsuteru ; Nishiofuku, Hideyuki ; Masada, Tetsuya ; Suzuki, Hiroyuki ; Koga, Hironori ; Torimura, Takuji ; Kichikawa, Kimihiko</creatorcontrib><description>Purpose
To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock.
Materials and Methods
Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion).
Result
The percentages of water-in-oil were 98.08 ± 0.27% in the emulsion formed by the device, while 70.3 ± 4.63% in the emulsion formed by a 3-way stopcock (
P
= 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 ± 0.38% and 98.70 ± 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 ± 19, 244 ± 24 and 478 ± 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 ± 8 min (
P
= 0.046–0.050). Suspension showed the longest release time; however, the viscosity was lowest.
Conclusion
The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-020-02757-2</identifier><identifier>PMID: 33415417</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Chemotherapy ; Cisplatin ; Cocks ; Emulsification ; Emulsions ; Hepatocellular carcinoma ; Imaging ; Interventional Oncology ; Laboratory Investigation ; Liver cancer ; Medicine ; Medicine & Public Health ; Membranes ; Nuclear Medicine ; Oil ; Physiochemistry ; Powder ; Radiology ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2021-05, Vol.44 (5), p.766-773</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-39f28830192a5f39a16f4d617c29f791a534d243fd1258aaf7a7714e8a977493</citedby><cites>FETCH-LOGICAL-c375t-39f28830192a5f39a16f4d617c29f791a534d243fd1258aaf7a7714e8a977493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-020-02757-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-020-02757-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33415417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Toshihiro</creatorcontrib><creatorcontrib>Iwamoto, Hideki</creatorcontrib><creatorcontrib>Fujihara, Mitsuteru</creatorcontrib><creatorcontrib>Nishiofuku, Hideyuki</creatorcontrib><creatorcontrib>Masada, Tetsuya</creatorcontrib><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Koga, Hironori</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Kichikawa, Kimihiko</creatorcontrib><title>Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock.
Materials and Methods
Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion).
Result
The percentages of water-in-oil were 98.08 ± 0.27% in the emulsion formed by the device, while 70.3 ± 4.63% in the emulsion formed by a 3-way stopcock (
P
= 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 ± 0.38% and 98.70 ± 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 ± 19, 244 ± 24 and 478 ± 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 ± 8 min (
P
= 0.046–0.050). Suspension showed the longest release time; however, the viscosity was lowest.
Conclusion
The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device.</description><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cocks</subject><subject>Emulsification</subject><subject>Emulsions</subject><subject>Hepatocellular carcinoma</subject><subject>Imaging</subject><subject>Interventional Oncology</subject><subject>Laboratory Investigation</subject><subject>Liver cancer</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membranes</subject><subject>Nuclear Medicine</subject><subject>Oil</subject><subject>Physiochemistry</subject><subject>Powder</subject><subject>Radiology</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctO3DAUhq2qVRmgL9BFZYkNm7S-xskSTYeLNAgWs2BnHRK7GDlxaifQeRWeFoehRWLRheWFv__30fkQ-krJd0qI-pEIYYoUhM1HSVWwD2hBBWcFqcqbj2hBqBIFlZLuof2U7gmhsmLyM9rjXFApqFqgp5W1roFmi4PFgM88pIQvTXcboTd41U0-uRkYXejxT_PgGoPHgE9D7PCl-zNO0czJpUuDz1CPr8NjayJ-dOMdXrvBhTZ4nLObXJggjiY68HhzZyIMW2xDxOdmgDE0xvvJQ8RLiI3rQweH6JMFn8yX1_sAbU5Xm-V5sb46u1ierIuGKzkWvLasqjihNQNpeQ20tKItqWpYbVVNQXLRMsFtS5msAKwCpagwFdRKiZofoONd7RDD78mkUXcuzdPkBYQpaSZUKcuy4iqjR-_Q-zDFPg-nmaSy5nmpM8V2VBNDStFYPUTXQdxqSvQsTu_E6SxOv4jTLIe-vVZPt51p_0X-msoA3wEpP_W_THz7-z-1z3wwpCM</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Tanaka, Toshihiro</creator><creator>Iwamoto, Hideki</creator><creator>Fujihara, Mitsuteru</creator><creator>Nishiofuku, Hideyuki</creator><creator>Masada, Tetsuya</creator><creator>Suzuki, Hiroyuki</creator><creator>Koga, Hironori</creator><creator>Torimura, Takuji</creator><creator>Kichikawa, Kimihiko</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210501</creationdate><title>Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma</title><author>Tanaka, Toshihiro ; Iwamoto, Hideki ; Fujihara, Mitsuteru ; Nishiofuku, Hideyuki ; Masada, Tetsuya ; Suzuki, Hiroyuki ; Koga, Hironori ; Torimura, Takuji ; Kichikawa, Kimihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-39f28830192a5f39a16f4d617c29f791a534d243fd1258aaf7a7714e8a977493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiology</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Cocks</topic><topic>Emulsification</topic><topic>Emulsions</topic><topic>Hepatocellular carcinoma</topic><topic>Imaging</topic><topic>Interventional Oncology</topic><topic>Laboratory Investigation</topic><topic>Liver cancer</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membranes</topic><topic>Nuclear Medicine</topic><topic>Oil</topic><topic>Physiochemistry</topic><topic>Powder</topic><topic>Radiology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Toshihiro</creatorcontrib><creatorcontrib>Iwamoto, Hideki</creatorcontrib><creatorcontrib>Fujihara, Mitsuteru</creatorcontrib><creatorcontrib>Nishiofuku, Hideyuki</creatorcontrib><creatorcontrib>Masada, Tetsuya</creatorcontrib><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Koga, Hironori</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Kichikawa, Kimihiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Toshihiro</au><au>Iwamoto, Hideki</au><au>Fujihara, Mitsuteru</au><au>Nishiofuku, Hideyuki</au><au>Masada, Tetsuya</au><au>Suzuki, Hiroyuki</au><au>Koga, Hironori</au><au>Torimura, Takuji</au><au>Kichikawa, Kimihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>44</volume><issue>5</issue><spage>766</spage><epage>773</epage><pages>766-773</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock.
Materials and Methods
Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion).
Result
The percentages of water-in-oil were 98.08 ± 0.27% in the emulsion formed by the device, while 70.3 ± 4.63% in the emulsion formed by a 3-way stopcock (
P
= 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 ± 0.38% and 98.70 ± 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 ± 19, 244 ± 24 and 478 ± 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 ± 8 min (
P
= 0.046–0.050). Suspension showed the longest release time; however, the viscosity was lowest.
Conclusion
The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33415417</pmid><doi>10.1007/s00270-020-02757-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Cardiology Chemotherapy Cisplatin Cocks Emulsification Emulsions Hepatocellular carcinoma Imaging Interventional Oncology Laboratory Investigation Liver cancer Medicine Medicine & Public Health Membranes Nuclear Medicine Oil Physiochemistry Powder Radiology Ultrasound |
| title | Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma |
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