Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography
Purpose To investigate the kinetic metrics of 2-[ 18 F]-fluoro-2-deoxy- d -glucose ( 18 F-FDG) in normal organs by using dynamic total-body (TB) positron emission tomography (PET). Methods Dynamic TB-PET was performed for nine healthy volunteers. Time-to-activity curves (TACs) were obtained by drawi...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-07, Vol.48 (8), p.2363-2372 |
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| creator | Liu, Guobing Xu, Hongrong Hu, Pengcheng Tan, Hui Zhang, Yiqiu Yu, Haojun Li, Xuening Shi, Hongcheng |
| description | Purpose
To investigate the kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-
d
-glucose (
18
F-FDG) in normal organs by using dynamic total-body (TB) positron emission tomography (PET).
Methods
Dynamic TB-PET was performed for nine healthy volunteers. Time-to-activity curves (TACs) were obtained by drawing regions of interest in the organs. A two-tissue compartment model was fitted for each tissue TAC. Constant rates, including
k
1
,
k
2
, and
k
3
, and the metabolic rate of FDG (MRFDG) were obtained. The parameter statistics, including the average, standard deviation, coefficient of variance, and inter-site and inter-individual variances, were compared.
Results
Constant rates and MRFDG varied significantly among organs and subjects, but not among sides or sub-regions within an organ. The mean
k
1
and
k
2
ranged from 0.0158 min
−1
in the right lower lung to 1.1883 min
−1
in the anterior wall of the left ventricle (LV) myocardium and from 0.1116 min
−1
in the left parietal white matter to 4.6272 min
−1
in the left thyroid, respectively. The
k
3
was lowest in the right upper area of the liver and highest in the septal wall of the LV myocardium. Mean MRFDG ranged from 23.1696 μmol/100 g/min in the parietal cortex to 0.5945 μmol/100 g/min in the lung. Four groups of organs with similar kinetic characteristics were identified: (1) the cerebral white matter, lung, liver, muscle, bone, and bone marrow; (2) cerebral and cerebellar cortex; (3) LV myocardium and thyroid; and (4) pancreas, spleen, and kidney.
Conclusion
The kinetic rates and MRFDG significantly differed among organs. The kinetic metrics of FDG parameters in normal organs can serve as a reference for future dynamic PET imaging and research. |
| doi_str_mv | 10.1007/s00259-020-05124-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2476564721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2546416075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-d5361ccf9b74e3dc5fc2a2ab1df86526190345afc9c7231622d0f00db6a087833</originalsourceid><addsrcrecordid>eNp9kT9v2zAUxIWgAZI6-QKZCGTpwuSREklpLNw6KRqgSzITFP_YDCTSIelB_fSl66IFOmR6N_zucA_XNDcE7giAuM8AlA0YKGBghHZ4OWsuCScDFtAPH_5qARfNx5xfAUhP--Gy-fndB1u8RrMtyeuMokOk3-DNlwfkAwoxzWpCu8OsAoppq0JG3thQvPPWoHFBecnFzuoYYZag5npLLGrCYzQL2sfsS4oB2dnn7KsocY7bpPa75ao5d2rK9vrPXTUvm6_P60f89OPh2_rzE9a0pwUb1nKitRtG0dnWaOY0VVSNxLieM1r_grZjyulBC9oSTqkBB2BGrqAXfduumk-n3H2Kbwebi6xdtJ0mFWw8ZEk7wRnvBCUVvf0PfY2HFGo7SVnHO8JBsErRE6VTzDlZJ_fJzyotkoA8ziFPc8g6h_w9h1yqqT2ZcoXD1qZ_0e-4fgEQ647v</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2546416075</pqid></control><display><type>article</type><title>Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography</title><source>SpringerLink Journals - AutoHoldings</source><creator>Liu, Guobing ; Xu, Hongrong ; Hu, Pengcheng ; Tan, Hui ; Zhang, Yiqiu ; Yu, Haojun ; Li, Xuening ; Shi, Hongcheng</creator><creatorcontrib>Liu, Guobing ; Xu, Hongrong ; Hu, Pengcheng ; Tan, Hui ; Zhang, Yiqiu ; Yu, Haojun ; Li, Xuening ; Shi, Hongcheng</creatorcontrib><description>Purpose
To investigate the kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-
d
-glucose (
18
F-FDG) in normal organs by using dynamic total-body (TB) positron emission tomography (PET).
Methods
Dynamic TB-PET was performed for nine healthy volunteers. Time-to-activity curves (TACs) were obtained by drawing regions of interest in the organs. A two-tissue compartment model was fitted for each tissue TAC. Constant rates, including
k
1
,
k
2
, and
k
3
, and the metabolic rate of FDG (MRFDG) were obtained. The parameter statistics, including the average, standard deviation, coefficient of variance, and inter-site and inter-individual variances, were compared.
Results
Constant rates and MRFDG varied significantly among organs and subjects, but not among sides or sub-regions within an organ. The mean
k
1
and
k
2
ranged from 0.0158 min
−1
in the right lower lung to 1.1883 min
−1
in the anterior wall of the left ventricle (LV) myocardium and from 0.1116 min
−1
in the left parietal white matter to 4.6272 min
−1
in the left thyroid, respectively. The
k
3
was lowest in the right upper area of the liver and highest in the septal wall of the LV myocardium. Mean MRFDG ranged from 23.1696 μmol/100 g/min in the parietal cortex to 0.5945 μmol/100 g/min in the lung. Four groups of organs with similar kinetic characteristics were identified: (1) the cerebral white matter, lung, liver, muscle, bone, and bone marrow; (2) cerebral and cerebellar cortex; (3) LV myocardium and thyroid; and (4) pancreas, spleen, and kidney.
Conclusion
The kinetic rates and MRFDG significantly differed among organs. The kinetic metrics of FDG parameters in normal organs can serve as a reference for future dynamic PET imaging and research.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-020-05124-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bone marrow ; Cardiology ; Cerebellum ; Cortex (parietal) ; Emission analysis ; Fluorine isotopes ; Glucose ; Imaging ; Liver ; Lungs ; Mean ; Medicine ; Medicine & Public Health ; Metabolic rate ; Muscles ; Myocardium ; Neuroimaging ; Nuclear Medicine ; Oncology ; Organs ; Original Article ; Orthopedics ; Pancreas ; Parameters ; Positron emission ; Positron emission tomography ; Radiology ; Radiopharmacy ; Spleen ; Substantia alba ; Thyroid ; Thyroid gland ; Tomography ; Ventricle</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-07, Vol.48 (8), p.2363-2372</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-d5361ccf9b74e3dc5fc2a2ab1df86526190345afc9c7231622d0f00db6a087833</citedby><cites>FETCH-LOGICAL-c282t-d5361ccf9b74e3dc5fc2a2ab1df86526190345afc9c7231622d0f00db6a087833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-020-05124-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-020-05124-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Liu, Guobing</creatorcontrib><creatorcontrib>Xu, Hongrong</creatorcontrib><creatorcontrib>Hu, Pengcheng</creatorcontrib><creatorcontrib>Tan, Hui</creatorcontrib><creatorcontrib>Zhang, Yiqiu</creatorcontrib><creatorcontrib>Yu, Haojun</creatorcontrib><creatorcontrib>Li, Xuening</creatorcontrib><creatorcontrib>Shi, Hongcheng</creatorcontrib><title>Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To investigate the kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-
d
-glucose (
18
F-FDG) in normal organs by using dynamic total-body (TB) positron emission tomography (PET).
Methods
Dynamic TB-PET was performed for nine healthy volunteers. Time-to-activity curves (TACs) were obtained by drawing regions of interest in the organs. A two-tissue compartment model was fitted for each tissue TAC. Constant rates, including
k
1
,
k
2
, and
k
3
, and the metabolic rate of FDG (MRFDG) were obtained. The parameter statistics, including the average, standard deviation, coefficient of variance, and inter-site and inter-individual variances, were compared.
Results
Constant rates and MRFDG varied significantly among organs and subjects, but not among sides or sub-regions within an organ. The mean
k
1
and
k
2
ranged from 0.0158 min
−1
in the right lower lung to 1.1883 min
−1
in the anterior wall of the left ventricle (LV) myocardium and from 0.1116 min
−1
in the left parietal white matter to 4.6272 min
−1
in the left thyroid, respectively. The
k
3
was lowest in the right upper area of the liver and highest in the septal wall of the LV myocardium. Mean MRFDG ranged from 23.1696 μmol/100 g/min in the parietal cortex to 0.5945 μmol/100 g/min in the lung. Four groups of organs with similar kinetic characteristics were identified: (1) the cerebral white matter, lung, liver, muscle, bone, and bone marrow; (2) cerebral and cerebellar cortex; (3) LV myocardium and thyroid; and (4) pancreas, spleen, and kidney.
Conclusion
The kinetic rates and MRFDG significantly differed among organs. The kinetic metrics of FDG parameters in normal organs can serve as a reference for future dynamic PET imaging and research.</description><subject>Bone marrow</subject><subject>Cardiology</subject><subject>Cerebellum</subject><subject>Cortex (parietal)</subject><subject>Emission analysis</subject><subject>Fluorine isotopes</subject><subject>Glucose</subject><subject>Imaging</subject><subject>Liver</subject><subject>Lungs</subject><subject>Mean</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic rate</subject><subject>Muscles</subject><subject>Myocardium</subject><subject>Neuroimaging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Organs</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Pancreas</subject><subject>Parameters</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiology</subject><subject>Radiopharmacy</subject><subject>Spleen</subject><subject>Substantia alba</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Tomography</subject><subject>Ventricle</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kT9v2zAUxIWgAZI6-QKZCGTpwuSREklpLNw6KRqgSzITFP_YDCTSIelB_fSl66IFOmR6N_zucA_XNDcE7giAuM8AlA0YKGBghHZ4OWsuCScDFtAPH_5qARfNx5xfAUhP--Gy-fndB1u8RrMtyeuMokOk3-DNlwfkAwoxzWpCu8OsAoppq0JG3thQvPPWoHFBecnFzuoYYZag5npLLGrCYzQL2sfsS4oB2dnn7KsocY7bpPa75ao5d2rK9vrPXTUvm6_P60f89OPh2_rzE9a0pwUb1nKitRtG0dnWaOY0VVSNxLieM1r_grZjyulBC9oSTqkBB2BGrqAXfduumk-n3H2Kbwebi6xdtJ0mFWw8ZEk7wRnvBCUVvf0PfY2HFGo7SVnHO8JBsErRE6VTzDlZJ_fJzyotkoA8ziFPc8g6h_w9h1yqqT2ZcoXD1qZ_0e-4fgEQ647v</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Liu, Guobing</creator><creator>Xu, Hongrong</creator><creator>Hu, Pengcheng</creator><creator>Tan, Hui</creator><creator>Zhang, Yiqiu</creator><creator>Yu, Haojun</creator><creator>Li, Xuening</creator><creator>Shi, Hongcheng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210701</creationdate><title>Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography</title><author>Liu, Guobing ; Xu, Hongrong ; Hu, Pengcheng ; Tan, Hui ; Zhang, Yiqiu ; Yu, Haojun ; Li, Xuening ; Shi, Hongcheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-d5361ccf9b74e3dc5fc2a2ab1df86526190345afc9c7231622d0f00db6a087833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone marrow</topic><topic>Cardiology</topic><topic>Cerebellum</topic><topic>Cortex (parietal)</topic><topic>Emission analysis</topic><topic>Fluorine isotopes</topic><topic>Glucose</topic><topic>Imaging</topic><topic>Liver</topic><topic>Lungs</topic><topic>Mean</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic rate</topic><topic>Muscles</topic><topic>Myocardium</topic><topic>Neuroimaging</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Organs</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Pancreas</topic><topic>Parameters</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiology</topic><topic>Radiopharmacy</topic><topic>Spleen</topic><topic>Substantia alba</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Tomography</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Guobing</creatorcontrib><creatorcontrib>Xu, Hongrong</creatorcontrib><creatorcontrib>Hu, Pengcheng</creatorcontrib><creatorcontrib>Tan, Hui</creatorcontrib><creatorcontrib>Zhang, Yiqiu</creatorcontrib><creatorcontrib>Yu, Haojun</creatorcontrib><creatorcontrib>Li, Xuening</creatorcontrib><creatorcontrib>Shi, Hongcheng</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Guobing</au><au>Xu, Hongrong</au><au>Hu, Pengcheng</au><au>Tan, Hui</au><au>Zhang, Yiqiu</au><au>Yu, Haojun</au><au>Li, Xuening</au><au>Shi, Hongcheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>48</volume><issue>8</issue><spage>2363</spage><epage>2372</epage><pages>2363-2372</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To investigate the kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-
d
-glucose (
18
F-FDG) in normal organs by using dynamic total-body (TB) positron emission tomography (PET).
Methods
Dynamic TB-PET was performed for nine healthy volunteers. Time-to-activity curves (TACs) were obtained by drawing regions of interest in the organs. A two-tissue compartment model was fitted for each tissue TAC. Constant rates, including
k
1
,
k
2
, and
k
3
, and the metabolic rate of FDG (MRFDG) were obtained. The parameter statistics, including the average, standard deviation, coefficient of variance, and inter-site and inter-individual variances, were compared.
Results
Constant rates and MRFDG varied significantly among organs and subjects, but not among sides or sub-regions within an organ. The mean
k
1
and
k
2
ranged from 0.0158 min
−1
in the right lower lung to 1.1883 min
−1
in the anterior wall of the left ventricle (LV) myocardium and from 0.1116 min
−1
in the left parietal white matter to 4.6272 min
−1
in the left thyroid, respectively. The
k
3
was lowest in the right upper area of the liver and highest in the septal wall of the LV myocardium. Mean MRFDG ranged from 23.1696 μmol/100 g/min in the parietal cortex to 0.5945 μmol/100 g/min in the lung. Four groups of organs with similar kinetic characteristics were identified: (1) the cerebral white matter, lung, liver, muscle, bone, and bone marrow; (2) cerebral and cerebellar cortex; (3) LV myocardium and thyroid; and (4) pancreas, spleen, and kidney.
Conclusion
The kinetic rates and MRFDG significantly differed among organs. The kinetic metrics of FDG parameters in normal organs can serve as a reference for future dynamic PET imaging and research.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00259-020-05124-y</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
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| issn | 1619-7070 1619-7089 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Bone marrow Cardiology Cerebellum Cortex (parietal) Emission analysis Fluorine isotopes Glucose Imaging Liver Lungs Mean Medicine Medicine & Public Health Metabolic rate Muscles Myocardium Neuroimaging Nuclear Medicine Oncology Organs Original Article Orthopedics Pancreas Parameters Positron emission Positron emission tomography Radiology Radiopharmacy Spleen Substantia alba Thyroid Thyroid gland Tomography Ventricle |
| title | Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography |
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