Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats
Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegener...
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| Veröffentlicht in: | Molecular neurobiology 2021-05, Vol.58 (5), p.2256-2268 |
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| creator | dos Santos Cardoso, Fabrízio dos Santos, Júlio César Claudino Gonzalez-Lima, Francisco Araújo, Bruno Henrique Silva Lopes-Martins, Rodrigo Álvaro Brandão Gomes da Silva, Sérgio |
| description | Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature. |
| doi_str_mv | 10.1007/s12035-020-02247-z |
| format | Article |
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Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-020-02247-z</identifier><identifier>PMID: 33417219</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aging ; Antioxidants ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cerebral cortex ; Cognition ; Cognitive ability ; Energy metabolism ; Hippocampus ; Homeostasis ; I.R. radiation ; Inflammation ; Lasers ; Light therapy ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolomics ; Neurobiology ; Neurodegeneration ; Neurology ; Neuroprotection ; Neurosciences ; Neurotransmission ; Oxidative metabolism ; Oxidative stress ; Rodents ; Statistical analysis</subject><ispartof>Molecular neurobiology, 2021-05, Vol.58 (5), p.2256-2268</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a8f2d023645d1f7ff47c864c741353d15b69e443a99899a2093e9d4eefa8e0013</citedby><cites>FETCH-LOGICAL-c375t-a8f2d023645d1f7ff47c864c741353d15b69e443a99899a2093e9d4eefa8e0013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-020-02247-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-020-02247-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33417219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Santos Cardoso, Fabrízio</creatorcontrib><creatorcontrib>dos Santos, Júlio César Claudino</creatorcontrib><creatorcontrib>Gonzalez-Lima, Francisco</creatorcontrib><creatorcontrib>Araújo, Bruno Henrique Silva</creatorcontrib><creatorcontrib>Lopes-Martins, Rodrigo Álvaro Brandão</creatorcontrib><creatorcontrib>Gomes da Silva, Sérgio</creatorcontrib><title>Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature.</description><subject>Aging</subject><subject>Antioxidants</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cerebral cortex</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Energy metabolism</subject><subject>Hippocampus</subject><subject>Homeostasis</subject><subject>I.R. radiation</subject><subject>Inflammation</subject><subject>Lasers</subject><subject>Light therapy</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Neurobiology</subject><subject>Neurodegeneration</subject><subject>Neurology</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Neurotransmission</subject><subject>Oxidative metabolism</subject><subject>Oxidative stress</subject><subject>Rodents</subject><subject>Statistical 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neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>58</volume><issue>5</issue><spage>2256</spage><epage>2268</epage><pages>2256-2268</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. 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| subjects | Aging Antioxidants Biomedical and Life Sciences Biomedicine Cell Biology Cerebral cortex Cognition Cognitive ability Energy metabolism Hippocampus Homeostasis I.R. radiation Inflammation Lasers Light therapy Metabolic pathways Metabolism Metabolites Metabolomics Neurobiology Neurodegeneration Neurology Neuroprotection Neurosciences Neurotransmission Oxidative metabolism Oxidative stress Rodents Statistical analysis |
| title | Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats |
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