TatD DNases of African trypanosomes confer resistance to host neutrophil extracellular traps

African trypanosomatid parasites escape host acquired immune responses through periodic antigenic variation of their surface coat. In this study, we describe a mechanism by which the parasites counteract innate immune responses. Two TatD DNases were identified in each of Trypanosoma evansi and Trypa...

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Veröffentlicht in:	Science China. Life sciences 2021-04, Vol.64 (4), p.621-632
Hauptverfasser:	Zhang, Kai, Jiang, Ning, Chen, Hongyu, Zhang, Naiwen, Sang, Xiaoyu, Feng, Ying, Chen, Ran, Chen, Qijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aurintricarboxylic acid Biomedical and Life Sciences Cytoplasm Deoxyribonuclease Deoxyribonucleases - genetics Deoxyribonucleases - immunology Deoxyribonucleases - metabolism Extracellular Traps - immunology Extracellular Traps - metabolism Extracellular Traps - parasitology Female Flagella Host-Pathogen Interactions - immunology Immune Evasion - immunology Immune response Immunity, Innate - immunology Innate immunity Leukocytes (neutrophilic) Life Sciences Mice Mice, Inbred BALB C Microscopy, Electron, Scanning Microscopy, Immunoelectron Neutrophils Neutrophils - immunology Neutrophils - metabolism Neutrophils - parasitology Parasites Phylogeny Protozoa Protozoan Infections, Animal - immunology Protozoan Infections, Animal - parasitology Protozoan Proteins - classification Protozoan Proteins - immunology Protozoan Proteins - metabolism Rats Rats, Sprague-Dawley Research Paper Sequence Homology, Amino Acid Species Specificity Trypanosoma - immunology Trypanosoma - metabolism Trypanosoma - ultrastructure Trypanosoma brucei brucei - immunology Trypanosoma brucei brucei - metabolism Trypanosoma brucei brucei - ultrastructure
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