Thermal stability of cannabinoids in dried cannabis: a kinetic study
This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from − 20 to + 40 ∘ C lasting up t...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2022, Vol.414 (1), p.377-384 |
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| creator | Meija, Juris McRae, Garnet Miles, Christopher O. Melanson, Jeremy E. |
| description | This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from − 20 to + 40
∘
C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products. |
| doi_str_mv | 10.1007/s00216-020-03098-2 |
| format | Article |
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∘
C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-020-03098-2</identifier><identifier>PMID: 33420535</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>ABCs 20th Anniversary ; Analysis ; Analytical Chemistry ; Biochemistry ; Cannabinoids ; Cannabinoids - analysis ; Cannabis ; Cannabis - chemistry ; Characterization and Evaluation of Materials ; Chemical reaction, Rate of ; Chemistry ; Chemistry and Materials Science ; Chromatography, High Pressure Liquid - methods ; Decomposition (Chemistry) ; Degradation ; Food Science ; High temperature ; High temperature effects ; Identification and classification ; Kinetics ; Laboratory Medicine ; Liquid chromatography ; Marijuana ; Mass spectrometry ; Mass spectroscopy ; Methods ; Monitoring/Environmental Analysis ; Properties ; Research Paper ; Room temperature ; Shelf life ; Tandem Mass Spectrometry - methods ; Temperature effects ; Thermal stability</subject><ispartof>Analytical and bioanalytical chemistry, 2022, Vol.414 (1), p.377-384</ispartof><rights>Crown 2021</rights><rights>2021. Crown.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>Crown 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-58e1616601fec21500ff902a7f974e1961e2ed936f1ea55d913488d4cd4630473</citedby><cites>FETCH-LOGICAL-c442t-58e1616601fec21500ff902a7f974e1961e2ed936f1ea55d913488d4cd4630473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-020-03098-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-020-03098-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33420535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meija, Juris</creatorcontrib><creatorcontrib>McRae, Garnet</creatorcontrib><creatorcontrib>Miles, Christopher O.</creatorcontrib><creatorcontrib>Melanson, Jeremy E.</creatorcontrib><title>Thermal stability of cannabinoids in dried cannabis: a kinetic study</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from − 20 to + 40
∘
C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.</description><subject>ABCs 20th Anniversary</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Cannabinoids</subject><subject>Cannabinoids - analysis</subject><subject>Cannabis</subject><subject>Cannabis - chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical reaction, Rate of</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Decomposition (Chemistry)</subject><subject>Degradation</subject><subject>Food Science</subject><subject>High temperature</subject><subject>High temperature effects</subject><subject>Identification and 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∘
C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33420535</pmid><doi>10.1007/s00216-020-03098-2</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1618-2642 |
| ispartof | Analytical and bioanalytical chemistry, 2022, Vol.414 (1), p.377-384 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | ABCs 20th Anniversary Analysis Analytical Chemistry Biochemistry Cannabinoids Cannabinoids - analysis Cannabis Cannabis - chemistry Characterization and Evaluation of Materials Chemical reaction, Rate of Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Decomposition (Chemistry) Degradation Food Science High temperature High temperature effects Identification and classification Kinetics Laboratory Medicine Liquid chromatography Marijuana Mass spectrometry Mass spectroscopy Methods Monitoring/Environmental Analysis Properties Research Paper Room temperature Shelf life Tandem Mass Spectrometry - methods Temperature effects Thermal stability |
| title | Thermal stability of cannabinoids in dried cannabis: a kinetic study |
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