Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin
Two-dimensional (2D) MoS 2 core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L -glutathione and cystamine ( L- GSH–MoS 2 –CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of d...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2021-02, Vol.188 (2), p.35-35, Article 35 |
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| container_title | Mikrochimica acta (1966) |
| container_volume | 188 |
| creator | Selvi, Subash Vetri Prasannan, Adhimoorthy Chen, Shen-Ming Vadivelmurugan, Adhisankar Tsai, Hsieh-Chih Lai, Juin-Yih |
| description | Two-dimensional (2D) MoS
2
core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with
L
-glutathione and cystamine (
L-
GSH–MoS
2
–CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM
−1
cm
−2
was acquired at 0.48 V. The fabricated
L-
GSH–MoS
2
–CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated
L-
GSH–MoS
2
–CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability.
Graphical abstract |
| doi_str_mv | 10.1007/s00604-020-04642-8 |
| format | Article |
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2
core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with
L
-glutathione and cystamine (
L-
GSH–MoS
2
–CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM
−1
cm
−2
was acquired at 0.48 V. The fabricated
L-
GSH–MoS
2
–CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated
L-
GSH–MoS
2
–CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability.
Graphical abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-020-04642-8</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Catalytic oxidation ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Doxorubicin ; Electrochemical analysis ; Electrodes ; Glutathione ; Microengineering ; Molybdenum disulfide ; Nanochemistry ; Nanoparticles ; Nanotechnology ; Optimization ; Original Paper ; Oxidation ; Reproducibility ; Selectivity</subject><ispartof>Mikrochimica acta (1966), 2021-02, Vol.188 (2), p.35-35, Article 35</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2021</rights><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-8758257e60ee24c8852039058231836578a1780c2a16e3f91264a93d0ba7d2e33</citedby><cites>FETCH-LOGICAL-c352t-8758257e60ee24c8852039058231836578a1780c2a16e3f91264a93d0ba7d2e33</cites><orcidid>0000-0002-0132-9161</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-020-04642-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-020-04642-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Selvi, Subash Vetri</creatorcontrib><creatorcontrib>Prasannan, Adhimoorthy</creatorcontrib><creatorcontrib>Chen, Shen-Ming</creatorcontrib><creatorcontrib>Vadivelmurugan, Adhisankar</creatorcontrib><creatorcontrib>Tsai, Hsieh-Chih</creatorcontrib><creatorcontrib>Lai, Juin-Yih</creatorcontrib><title>Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><description>Two-dimensional (2D) MoS
2
core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with
L
-glutathione and cystamine (
L-
GSH–MoS
2
–CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM
−1
cm
−2
was acquired at 0.48 V. The fabricated
L-
GSH–MoS
2
–CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated
L-
GSH–MoS
2
–CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability.
Graphical abstract</description><subject>Analytical Chemistry</subject><subject>Catalytic oxidation</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Doxorubicin</subject><subject>Electrochemical analysis</subject><subject>Electrodes</subject><subject>Glutathione</subject><subject>Microengineering</subject><subject>Molybdenum disulfide</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Optimization</subject><subject>Original Paper</subject><subject>Oxidation</subject><subject>Reproducibility</subject><subject>Selectivity</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rFTEUxYMo-Kz9Al0F3LiJ3vyZJLOUolVocaFdhzRzx5cyL3kmGbD65Zt2BMFFV5d7-J0D9x5Czji84wDmfQXQoBgIYKC0Esw-IzuupGYDGPmc7ACEZlIb8ZK8qvUWgBst1I78uVjW5ts-5oTUp4mGu9r8IfZtXlNoXfdL_I0TvcrfRMgFWd3jstDkUz760mJYsNI5F4pp71PoJC4YWslhj4cY_EInbPiYRPNMp_wrl_UmhphekxezXyqe_p0n5PrTx-_nn9nl14sv5x8uWZCDaMyawYrBoAZEoYK1gwA5Qhclt1IPxnpuLAThuUY5j1xo5Uc5wY03k0ApT8jbLfdY8s8Va3OHWEM_wifMa3VCGT1okDB29M1_6G1eS3_BRkmpRms7JTYqlFxrwdkdSzz4cuc4uIc-3NaH6324xz7cg0luptrh9APLv-gnXPfcHY5W</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Selvi, Subash Vetri</creator><creator>Prasannan, Adhimoorthy</creator><creator>Chen, Shen-Ming</creator><creator>Vadivelmurugan, Adhisankar</creator><creator>Tsai, Hsieh-Chih</creator><creator>Lai, Juin-Yih</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0132-9161</orcidid></search><sort><creationdate>20210201</creationdate><title>Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin</title><author>Selvi, Subash Vetri ; Prasannan, Adhimoorthy ; Chen, Shen-Ming ; Vadivelmurugan, Adhisankar ; Tsai, Hsieh-Chih ; Lai, Juin-Yih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-8758257e60ee24c8852039058231836578a1780c2a16e3f91264a93d0ba7d2e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analytical Chemistry</topic><topic>Catalytic oxidation</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Doxorubicin</topic><topic>Electrochemical analysis</topic><topic>Electrodes</topic><topic>Glutathione</topic><topic>Microengineering</topic><topic>Molybdenum disulfide</topic><topic>Nanochemistry</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Optimization</topic><topic>Original Paper</topic><topic>Oxidation</topic><topic>Reproducibility</topic><topic>Selectivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selvi, Subash Vetri</creatorcontrib><creatorcontrib>Prasannan, Adhimoorthy</creatorcontrib><creatorcontrib>Chen, Shen-Ming</creatorcontrib><creatorcontrib>Vadivelmurugan, Adhisankar</creatorcontrib><creatorcontrib>Tsai, Hsieh-Chih</creatorcontrib><creatorcontrib>Lai, Juin-Yih</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selvi, Subash Vetri</au><au>Prasannan, Adhimoorthy</au><au>Chen, Shen-Ming</au><au>Vadivelmurugan, Adhisankar</au><au>Tsai, Hsieh-Chih</au><au>Lai, Juin-Yih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><date>2021-02-01</date><risdate>2021</risdate><volume>188</volume><issue>2</issue><spage>35</spage><epage>35</epage><pages>35-35</pages><artnum>35</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>Two-dimensional (2D) MoS
2
core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with
L
-glutathione and cystamine (
L-
GSH–MoS
2
–CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM
−1
cm
−2
was acquired at 0.48 V. The fabricated
L-
GSH–MoS
2
–CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated
L-
GSH–MoS
2
–CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability.
Graphical abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00604-020-04642-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0132-9161</orcidid></addata></record> |
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| language | eng |
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| subjects | Analytical Chemistry Catalytic oxidation Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Doxorubicin Electrochemical analysis Electrodes Glutathione Microengineering Molybdenum disulfide Nanochemistry Nanoparticles Nanotechnology Optimization Original Paper Oxidation Reproducibility Selectivity |
| title | Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin |
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