Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Two-dimensional (2D) MoS 2 core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L -glutathione and cystamine ( L- GSH–MoS 2 –CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM −1 cm −2 was acquired at 0.48 V. The fabricated L- GSH–MoS 2 –CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated L- GSH–MoS 2 –CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability. Graphical abstract