Tendinopathy
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Ach...
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| Veröffentlicht in: | Nature reviews. Disease primers 2021-01, Vol.7 (1), p.1-1, Article 1 |
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| creator | Millar, Neal L. Silbernagel, Karin G. Thorborg, Kristian Kirwan, Paul D. Galatz, Leesa M. Abrams, Geoffrey D. Murrell, George A. C. McInnes, Iain B. Rodeo, Scott A. |
| description | Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.
Tendinopathy is a multifaceted pathology of the tendon, characterized by pain and reduced function. This Primer summarizes the epidemiology, pathophysiology, diagnosis and the latest insights in the management of this disorder. Finally, the authors discuss the outstanding issues that will help achieve better outcomes in patients with tendinopathy. |
| doi_str_mv | 10.1038/s41572-020-00234-1 |
| format | Article |
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Tendinopathy is a multifaceted pathology of the tendon, characterized by pain and reduced function. This Primer summarizes the epidemiology, pathophysiology, diagnosis and the latest insights in the management of this disorder. Finally, the authors discuss the outstanding issues that will help achieve better outcomes in patients with tendinopathy.</description><identifier>ISSN: 2056-676X</identifier><identifier>EISSN: 2056-676X</identifier><identifier>DOI: 10.1038/s41572-020-00234-1</identifier><identifier>PMID: 33414454</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1537/805 ; 692/699/1670/1669 ; Cancer Research ; Disease ; Epidemiology ; Inflammation ; Internal Medicine ; Medical Microbiology ; Medicine ; Medicine & Public Health ; National libraries ; Pain ; Pathogenesis ; Pathology ; Peer review ; Primer ; Quality of life ; Quality of Life Research ; Rotator cuff ; Stem cells ; Surgery ; Systematic review ; Tendons</subject><ispartof>Nature reviews. Disease primers, 2021-01, Vol.7 (1), p.1-1, Article 1</ispartof><rights>Springer Nature Limited 2021. corrected publication 2021</rights><rights>Springer Nature Limited 2021. corrected publication 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-ab50c7ada4fafdeff78e7f1227f5eac4396279fea5471ccbac8602420bd651053</cites><orcidid>0000-0001-9251-9907 ; 0000-0002-0745-9880 ; 0000-0003-4449-8501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33414454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Millar, Neal L.</creatorcontrib><creatorcontrib>Silbernagel, Karin G.</creatorcontrib><creatorcontrib>Thorborg, Kristian</creatorcontrib><creatorcontrib>Kirwan, Paul D.</creatorcontrib><creatorcontrib>Galatz, Leesa M.</creatorcontrib><creatorcontrib>Abrams, Geoffrey D.</creatorcontrib><creatorcontrib>Murrell, George A. C.</creatorcontrib><creatorcontrib>McInnes, Iain B.</creatorcontrib><creatorcontrib>Rodeo, Scott A.</creatorcontrib><title>Tendinopathy</title><title>Nature reviews. Disease primers</title><addtitle>Nat Rev Dis Primers</addtitle><addtitle>Nat Rev Dis Primers</addtitle><description>Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.
Tendinopathy is a multifaceted pathology of the tendon, characterized by pain and reduced function. This Primer summarizes the epidemiology, pathophysiology, diagnosis and the latest insights in the management of this disorder. 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Disease primers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Millar, Neal L.</au><au>Silbernagel, Karin G.</au><au>Thorborg, Kristian</au><au>Kirwan, Paul D.</au><au>Galatz, Leesa M.</au><au>Abrams, Geoffrey D.</au><au>Murrell, George A. C.</au><au>McInnes, Iain B.</au><au>Rodeo, Scott A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tendinopathy</atitle><jtitle>Nature reviews. Disease primers</jtitle><stitle>Nat Rev Dis Primers</stitle><addtitle>Nat Rev Dis Primers</addtitle><date>2021-01-07</date><risdate>2021</risdate><volume>7</volume><issue>1</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><artnum>1</artnum><issn>2056-676X</issn><eissn>2056-676X</eissn><abstract>Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.
Tendinopathy is a multifaceted pathology of the tendon, characterized by pain and reduced function. This Primer summarizes the epidemiology, pathophysiology, diagnosis and the latest insights in the management of this disorder. Finally, the authors discuss the outstanding issues that will help achieve better outcomes in patients with tendinopathy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33414454</pmid><doi>10.1038/s41572-020-00234-1</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9251-9907</orcidid><orcidid>https://orcid.org/0000-0002-0745-9880</orcidid><orcidid>https://orcid.org/0000-0003-4449-8501</orcidid></addata></record> |
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| subjects | 692/1537/805 692/699/1670/1669 Cancer Research Disease Epidemiology Inflammation Internal Medicine Medical Microbiology Medicine Medicine & Public Health National libraries Pain Pathogenesis Pathology Peer review Primer Quality of life Quality of Life Research Rotator cuff Stem cells Surgery Systematic review Tendons |
| title | Tendinopathy |
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