The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits
Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous hum...
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| Veröffentlicht in: | Biological trace element research 2021-11, Vol.199 (11), p.4154-4161 |
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| creator | Ergun, Dilek Duzgun Dursun, Sefik Ergun, Sefa Ozcelik, Dervis |
| description | Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous humor fluid in diabetic and non-diabetic conditions. Therefore, we aimed to investigate zinc (Zn), copper (Cu), and chromium (Cr) levels in plasma and aqueous humor fluids of rabbits in the diabetic rabbit model. New Zealand male rabbits were divided into two groups as control (
n
= 8), and diabetes (
n
= 8) induced by alloxane. At the end of the experimental period, the osmolality in blood, plasma, and aqueous humor fluids from rabbits were measured by osmometer and Zn, Cu, and Cr levels in plasma and aqueous humor fluid were measured by inductively coupled plasma–optical emission spectrophotometer (ICP-OES). The osmolality in blood, plasma, and aqueous humor fluid of the diabetic group was significantly increased compared to the control group (respectively
p
|
| doi_str_mv | 10.1007/s12011-020-02538-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2476128787</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2476128787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a971a490fa369e4d6d017a5b205db951fde02b07ba44e112f09539768be4a2ca3</originalsourceid><addsrcrecordid>eNp9kUtvFTEMhSMEopfCH2CBIrFhM-C8JpPlpQ-KVKkIXdaRM-OBlHmUZEZV_z25vS1ILFhYXvjz8ZEPY68FvBcA9kMWEoSoQEIpo5rKPGEbYYyrwEp4yjYgalVp1-gj9iLnawBhpVPP2ZFSGpwT9Yb93P0gvs15biMucZ74R1puiSa-S9gSPxtopGnJHKeOX-VxHnCIyx2PE_8yYB7xfrD9tdK8Zn6xjnPi58Mauz1xGjHQElv-FUOIS37JnvU4ZHr10I_Zt_Oz3clFdXn16fPJ9rJqlTVLhc4K1A56VLUj3dVd8Y0mSDBdcEb0HYEMYANqTULIHpxRztZNII2yRXXM3h10b9JcnOXFjzG3NAw47W16qW0tZGMbW9C3_6DX85qm4s5LY01tyid1oeSBatOcc6Le36Q4YrrzAvw-Cn-Iwpco_H0U3pSlNw_Saxip-7Py-PsCqAOQy2j6Tunv7f_I_gYwkZLu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2575650724</pqid></control><display><type>article</type><title>The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ergun, Dilek Duzgun ; Dursun, Sefik ; Ergun, Sefa ; Ozcelik, Dervis</creator><creatorcontrib>Ergun, Dilek Duzgun ; Dursun, Sefik ; Ergun, Sefa ; Ozcelik, Dervis</creatorcontrib><description><![CDATA[Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous humor fluid in diabetic and non-diabetic conditions. Therefore, we aimed to investigate zinc (Zn), copper (Cu), and chromium (Cr) levels in plasma and aqueous humor fluids of rabbits in the diabetic rabbit model. New Zealand male rabbits were divided into two groups as control (
n
= 8), and diabetes (
n
= 8) induced by alloxane. At the end of the experimental period, the osmolality in blood, plasma, and aqueous humor fluids from rabbits were measured by osmometer and Zn, Cu, and Cr levels in plasma and aqueous humor fluid were measured by inductively coupled plasma–optical emission spectrophotometer (ICP-OES). The osmolality in blood, plasma, and aqueous humor fluid of the diabetic group was significantly increased compared to the control group (respectively
p
< 0.01,
p
< 0.001,
p
< 0.001). It was analyzed that plasma Zn and Cu levels of diabetic rabbits increased significantly (respectively,
p
< 0.01;
p
< 0.001), whereas Cr level significantly decreased according to the control group (
p
< 0.01). It was observed that Cr and Zn levels in aqueous humor fluid in diabetes group decreased (respectively
p
< 0.001 and
p
< 0.01), and a significantly increased in Cu level (
p
< 0.001) compared to the control group. Related with these changes that may occur in the eye due to the measured parameters, we consider that comparative studies of these types of diabetic animal models would be useful in the evaluation of diabetes and its complications.]]></description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02538-5</identifier><identifier>PMID: 33409916</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal models ; Animals ; Aqueous Humor ; Aqueous humour ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood ; Cataracts ; Chromium ; Comparative analysis ; Comparative studies ; Control ; Copper ; Diabetes ; Diabetes Mellitus ; Emission measurements ; Evaluation ; Fluids ; Glaucoma ; Inductively coupled plasma ; Life Sciences ; Male ; Metabolism ; Nutrition ; Oncology ; Osmolar Concentration ; Plasma ; Rabbits ; Spectrophotometers ; Trace Elements ; Zinc</subject><ispartof>Biological trace element research, 2021-11, Vol.199 (11), p.4154-4161</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a971a490fa369e4d6d017a5b205db951fde02b07ba44e112f09539768be4a2ca3</citedby><cites>FETCH-LOGICAL-c375t-a971a490fa369e4d6d017a5b205db951fde02b07ba44e112f09539768be4a2ca3</cites><orcidid>0000-0002-6245-6631</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02538-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02538-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33409916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ergun, Dilek Duzgun</creatorcontrib><creatorcontrib>Dursun, Sefik</creatorcontrib><creatorcontrib>Ergun, Sefa</creatorcontrib><creatorcontrib>Ozcelik, Dervis</creatorcontrib><title>The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description><![CDATA[Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous humor fluid in diabetic and non-diabetic conditions. Therefore, we aimed to investigate zinc (Zn), copper (Cu), and chromium (Cr) levels in plasma and aqueous humor fluids of rabbits in the diabetic rabbit model. New Zealand male rabbits were divided into two groups as control (
n
= 8), and diabetes (
n
= 8) induced by alloxane. At the end of the experimental period, the osmolality in blood, plasma, and aqueous humor fluids from rabbits were measured by osmometer and Zn, Cu, and Cr levels in plasma and aqueous humor fluid were measured by inductively coupled plasma–optical emission spectrophotometer (ICP-OES). The osmolality in blood, plasma, and aqueous humor fluid of the diabetic group was significantly increased compared to the control group (respectively
p
< 0.01,
p
< 0.001,
p
< 0.001). It was analyzed that plasma Zn and Cu levels of diabetic rabbits increased significantly (respectively,
p
< 0.01;
p
< 0.001), whereas Cr level significantly decreased according to the control group (
p
< 0.01). It was observed that Cr and Zn levels in aqueous humor fluid in diabetes group decreased (respectively
p
< 0.001 and
p
< 0.01), and a significantly increased in Cu level (
p
< 0.001) compared to the control group. Related with these changes that may occur in the eye due to the measured parameters, we consider that comparative studies of these types of diabetic animal models would be useful in the evaluation of diabetes and its complications.]]></description><subject>Animal models</subject><subject>Animals</subject><subject>Aqueous Humor</subject><subject>Aqueous humour</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Cataracts</subject><subject>Chromium</subject><subject>Comparative analysis</subject><subject>Comparative studies</subject><subject>Control</subject><subject>Copper</subject><subject>Diabetes</subject><subject>Diabetes Mellitus</subject><subject>Emission measurements</subject><subject>Evaluation</subject><subject>Fluids</subject><subject>Glaucoma</subject><subject>Inductively coupled plasma</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolism</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Osmolar Concentration</subject><subject>Plasma</subject><subject>Rabbits</subject><subject>Spectrophotometers</subject><subject>Trace 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Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits</title><author>Ergun, Dilek Duzgun ; Dursun, Sefik ; Ergun, Sefa ; Ozcelik, Dervis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a971a490fa369e4d6d017a5b205db951fde02b07ba44e112f09539768be4a2ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Aqueous Humor</topic><topic>Aqueous humour</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood</topic><topic>Cataracts</topic><topic>Chromium</topic><topic>Comparative analysis</topic><topic>Comparative studies</topic><topic>Control</topic><topic>Copper</topic><topic>Diabetes</topic><topic>Diabetes Mellitus</topic><topic>Emission measurements</topic><topic>Evaluation</topic><topic>Fluids</topic><topic>Glaucoma</topic><topic>Inductively coupled plasma</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metabolism</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Osmolar Concentration</topic><topic>Plasma</topic><topic>Rabbits</topic><topic>Spectrophotometers</topic><topic>Trace Elements</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ergun, Dilek Duzgun</creatorcontrib><creatorcontrib>Dursun, Sefik</creatorcontrib><creatorcontrib>Ergun, Sefa</creatorcontrib><creatorcontrib>Ozcelik, Dervis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>199</volume><issue>11</issue><spage>4154</spage><epage>4161</epage><pages>4154-4161</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract><![CDATA[Trace element metabolism plays an important role in the formation of diabetes and complications of diabetes. Although trace elements changes in lenses in diabetic cataract and glaucoma formation have been investigated, there were few studies evaluating trace elements levels in plasma and aqueous humor fluid in diabetic and non-diabetic conditions. Therefore, we aimed to investigate zinc (Zn), copper (Cu), and chromium (Cr) levels in plasma and aqueous humor fluids of rabbits in the diabetic rabbit model. New Zealand male rabbits were divided into two groups as control (
n
= 8), and diabetes (
n
= 8) induced by alloxane. At the end of the experimental period, the osmolality in blood, plasma, and aqueous humor fluids from rabbits were measured by osmometer and Zn, Cu, and Cr levels in plasma and aqueous humor fluid were measured by inductively coupled plasma–optical emission spectrophotometer (ICP-OES). The osmolality in blood, plasma, and aqueous humor fluid of the diabetic group was significantly increased compared to the control group (respectively
p
< 0.01,
p
< 0.001,
p
< 0.001). It was analyzed that plasma Zn and Cu levels of diabetic rabbits increased significantly (respectively,
p
< 0.01;
p
< 0.001), whereas Cr level significantly decreased according to the control group (
p
< 0.01). It was observed that Cr and Zn levels in aqueous humor fluid in diabetes group decreased (respectively
p
< 0.001 and
p
< 0.01), and a significantly increased in Cu level (
p
< 0.001) compared to the control group. Related with these changes that may occur in the eye due to the measured parameters, we consider that comparative studies of these types of diabetic animal models would be useful in the evaluation of diabetes and its complications.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>33409916</pmid><doi>10.1007/s12011-020-02538-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6245-6631</orcidid></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animal models Animals Aqueous Humor Aqueous humour Biochemistry Biomedical and Life Sciences Biotechnology Blood Cataracts Chromium Comparative analysis Comparative studies Control Copper Diabetes Diabetes Mellitus Emission measurements Evaluation Fluids Glaucoma Inductively coupled plasma Life Sciences Male Metabolism Nutrition Oncology Osmolar Concentration Plasma Rabbits Spectrophotometers Trace Elements Zinc |
| title | The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits |
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