Microfluidics for microalgal biotechnology
Microalgae have expanded their roles as renewable and sustainable feedstocks for biofuel, smart nutrition, biopharmaceutical, cosmeceutical, biosensing, and space technologies. They accumulate valuable biochemical compounds from protein, carbohydrate, and lipid groups, including pigments and caroten...
Gespeichert in:
Veröffentlicht in: | Biotechnology and bioengineering 2021-04, Vol.118 (4), p.1545-1563 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1563 |
---|---|
container_issue | 4 |
container_start_page | 1545 |
container_title | Biotechnology and bioengineering |
container_volume | 118 |
creator | Ozdalgic, Berin Ustun, Merve Dabbagh, Sajjad Rahmani Haznedaroglu, Berat Z. Kiraz, Alper Tasoglu, Savas |
description | Microalgae have expanded their roles as renewable and sustainable feedstocks for biofuel, smart nutrition, biopharmaceutical, cosmeceutical, biosensing, and space technologies. They accumulate valuable biochemical compounds from protein, carbohydrate, and lipid groups, including pigments and carotenoids. Microalgal biomass, which can be adopted for multivalorization under biorefinery settings, allows not only the production of various biofuels but also other value‐added biotechnological products. However, state‐of‐the‐art technologies are required to optimize yield, quality, and the economical aspects of both upstream and downstream processes. As such, the need to use microfluidic‐based devices for both fundamental research and industrial applications of microalgae, arises due to their microscale sizes and dilute cultures. Microfluidics‐based devices are superior to their competitors through their ability to perform multiple functions such as sorting and analyzing small amounts of samples (nanoliter to picoliter) with higher sensitivities. Here, we review emerging applications of microfluidic technologies on microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.
Although microalgae are used widely as biomass feedstocks, only a few hundred of the microalgae have been studied for their high‐value biocompounds and only a small fraction are cultivated industrially. This review by Tasoglu and coworkers highlights key factors and strategies using novel microfluidic platforms to study various microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition. |
doi_str_mv | 10.1002/bit.27669 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2476125440</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2501878411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3909-254140d49eb9327c8f2fc204a5a04473d3a66f44ed42c2e28a776c5ba2cb44d63</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlYP_gEpeFFh28nHJpujFj8KFS_1HLLZbE1JG910kf57U7d6EDwNMzy8M_MgdI5hhAHIuHSbERGcywPUxyBFBkTCIeoDAM9oLkkPncS4TK0oOD9GPUoZBkx4H908O9OE2reuciYO69AMV7uJ9gvth6ULG2ve1sGHxfYUHdXaR3u2rwP0-nA_nzxls5fH6eR2lhkqQWYkZ5hBxaQtJSXCFDWpDQGmcw2MCVpRzXnNmK0YMcSSQgvBTV5qYkrGKk4H6KrLfW_CR2vjRq1cNNZ7vbahjYowwXHawiChl3_QZWibdbpOkRxwIQqGcaKuOyr9FWNja_XeuJVutgqD2glUSaD6FpjYi31iW65s9Uv-GEvAuAM-nbfb_5PU3XTeRX4BUdR3uQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501878411</pqid></control><display><type>article</type><title>Microfluidics for microalgal biotechnology</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Ozdalgic, Berin ; Ustun, Merve ; Dabbagh, Sajjad Rahmani ; Haznedaroglu, Berat Z. ; Kiraz, Alper ; Tasoglu, Savas</creator><creatorcontrib>Ozdalgic, Berin ; Ustun, Merve ; Dabbagh, Sajjad Rahmani ; Haznedaroglu, Berat Z. ; Kiraz, Alper ; Tasoglu, Savas</creatorcontrib><description>Microalgae have expanded their roles as renewable and sustainable feedstocks for biofuel, smart nutrition, biopharmaceutical, cosmeceutical, biosensing, and space technologies. They accumulate valuable biochemical compounds from protein, carbohydrate, and lipid groups, including pigments and carotenoids. Microalgal biomass, which can be adopted for multivalorization under biorefinery settings, allows not only the production of various biofuels but also other value‐added biotechnological products. However, state‐of‐the‐art technologies are required to optimize yield, quality, and the economical aspects of both upstream and downstream processes. As such, the need to use microfluidic‐based devices for both fundamental research and industrial applications of microalgae, arises due to their microscale sizes and dilute cultures. Microfluidics‐based devices are superior to their competitors through their ability to perform multiple functions such as sorting and analyzing small amounts of samples (nanoliter to picoliter) with higher sensitivities. Here, we review emerging applications of microfluidic technologies on microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.
Although microalgae are used widely as biomass feedstocks, only a few hundred of the microalgae have been studied for their high‐value biocompounds and only a small fraction are cultivated industrially. This review by Tasoglu and coworkers highlights key factors and strategies using novel microfluidic platforms to study various microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.27669</identifier><identifier>PMID: 33410126</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Algae ; Aquatic microorganisms ; biochemicals ; Biodiesel fuels ; Biofuels ; Biopharmaceuticals ; Biorefineries ; biosensing ; Biosensors ; Biotechnology ; Carbohydrates ; Carotenoids ; cell harvesting ; cell sorting ; Cosmeceuticals ; Drug delivery ; Industrial applications ; Lab-On-A-Chip Devices ; Lipids ; microalgae ; Microalgae - growth & development ; Microfluidic Analytical Techniques ; Microfluidics ; Nutrition ; Pigments</subject><ispartof>Biotechnology and bioengineering, 2021-04, Vol.118 (4), p.1545-1563</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3909-254140d49eb9327c8f2fc204a5a04473d3a66f44ed42c2e28a776c5ba2cb44d63</citedby><cites>FETCH-LOGICAL-c3909-254140d49eb9327c8f2fc204a5a04473d3a66f44ed42c2e28a776c5ba2cb44d63</cites><orcidid>0000-0002-3883-4065 ; 0000-0002-0081-8801 ; 0000-0003-4604-217X ; 0000-0001-8888-6106 ; 0000-0001-7977-1286 ; 0000-0003-0113-541X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.27669$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.27669$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33410126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozdalgic, Berin</creatorcontrib><creatorcontrib>Ustun, Merve</creatorcontrib><creatorcontrib>Dabbagh, Sajjad Rahmani</creatorcontrib><creatorcontrib>Haznedaroglu, Berat Z.</creatorcontrib><creatorcontrib>Kiraz, Alper</creatorcontrib><creatorcontrib>Tasoglu, Savas</creatorcontrib><title>Microfluidics for microalgal biotechnology</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol Bioeng</addtitle><description>Microalgae have expanded their roles as renewable and sustainable feedstocks for biofuel, smart nutrition, biopharmaceutical, cosmeceutical, biosensing, and space technologies. They accumulate valuable biochemical compounds from protein, carbohydrate, and lipid groups, including pigments and carotenoids. Microalgal biomass, which can be adopted for multivalorization under biorefinery settings, allows not only the production of various biofuels but also other value‐added biotechnological products. However, state‐of‐the‐art technologies are required to optimize yield, quality, and the economical aspects of both upstream and downstream processes. As such, the need to use microfluidic‐based devices for both fundamental research and industrial applications of microalgae, arises due to their microscale sizes and dilute cultures. Microfluidics‐based devices are superior to their competitors through their ability to perform multiple functions such as sorting and analyzing small amounts of samples (nanoliter to picoliter) with higher sensitivities. Here, we review emerging applications of microfluidic technologies on microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.
Although microalgae are used widely as biomass feedstocks, only a few hundred of the microalgae have been studied for their high‐value biocompounds and only a small fraction are cultivated industrially. This review by Tasoglu and coworkers highlights key factors and strategies using novel microfluidic platforms to study various microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.</description><subject>Algae</subject><subject>Aquatic microorganisms</subject><subject>biochemicals</subject><subject>Biodiesel fuels</subject><subject>Biofuels</subject><subject>Biopharmaceuticals</subject><subject>Biorefineries</subject><subject>biosensing</subject><subject>Biosensors</subject><subject>Biotechnology</subject><subject>Carbohydrates</subject><subject>Carotenoids</subject><subject>cell harvesting</subject><subject>cell sorting</subject><subject>Cosmeceuticals</subject><subject>Drug delivery</subject><subject>Industrial applications</subject><subject>Lab-On-A-Chip Devices</subject><subject>Lipids</subject><subject>microalgae</subject><subject>Microalgae - growth & development</subject><subject>Microfluidic Analytical Techniques</subject><subject>Microfluidics</subject><subject>Nutrition</subject><subject>Pigments</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlYP_gEpeFFh28nHJpujFj8KFS_1HLLZbE1JG910kf57U7d6EDwNMzy8M_MgdI5hhAHIuHSbERGcywPUxyBFBkTCIeoDAM9oLkkPncS4TK0oOD9GPUoZBkx4H908O9OE2reuciYO69AMV7uJ9gvth6ULG2ve1sGHxfYUHdXaR3u2rwP0-nA_nzxls5fH6eR2lhkqQWYkZ5hBxaQtJSXCFDWpDQGmcw2MCVpRzXnNmK0YMcSSQgvBTV5qYkrGKk4H6KrLfW_CR2vjRq1cNNZ7vbahjYowwXHawiChl3_QZWibdbpOkRxwIQqGcaKuOyr9FWNja_XeuJVutgqD2glUSaD6FpjYi31iW65s9Uv-GEvAuAM-nbfb_5PU3XTeRX4BUdR3uQ</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Ozdalgic, Berin</creator><creator>Ustun, Merve</creator><creator>Dabbagh, Sajjad Rahmani</creator><creator>Haznedaroglu, Berat Z.</creator><creator>Kiraz, Alper</creator><creator>Tasoglu, Savas</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3883-4065</orcidid><orcidid>https://orcid.org/0000-0002-0081-8801</orcidid><orcidid>https://orcid.org/0000-0003-4604-217X</orcidid><orcidid>https://orcid.org/0000-0001-8888-6106</orcidid><orcidid>https://orcid.org/0000-0001-7977-1286</orcidid><orcidid>https://orcid.org/0000-0003-0113-541X</orcidid></search><sort><creationdate>202104</creationdate><title>Microfluidics for microalgal biotechnology</title><author>Ozdalgic, Berin ; Ustun, Merve ; Dabbagh, Sajjad Rahmani ; Haznedaroglu, Berat Z. ; Kiraz, Alper ; Tasoglu, Savas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3909-254140d49eb9327c8f2fc204a5a04473d3a66f44ed42c2e28a776c5ba2cb44d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algae</topic><topic>Aquatic microorganisms</topic><topic>biochemicals</topic><topic>Biodiesel fuels</topic><topic>Biofuels</topic><topic>Biopharmaceuticals</topic><topic>Biorefineries</topic><topic>biosensing</topic><topic>Biosensors</topic><topic>Biotechnology</topic><topic>Carbohydrates</topic><topic>Carotenoids</topic><topic>cell harvesting</topic><topic>cell sorting</topic><topic>Cosmeceuticals</topic><topic>Drug delivery</topic><topic>Industrial applications</topic><topic>Lab-On-A-Chip Devices</topic><topic>Lipids</topic><topic>microalgae</topic><topic>Microalgae - growth & development</topic><topic>Microfluidic Analytical Techniques</topic><topic>Microfluidics</topic><topic>Nutrition</topic><topic>Pigments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozdalgic, Berin</creatorcontrib><creatorcontrib>Ustun, Merve</creatorcontrib><creatorcontrib>Dabbagh, Sajjad Rahmani</creatorcontrib><creatorcontrib>Haznedaroglu, Berat Z.</creatorcontrib><creatorcontrib>Kiraz, Alper</creatorcontrib><creatorcontrib>Tasoglu, Savas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozdalgic, Berin</au><au>Ustun, Merve</au><au>Dabbagh, Sajjad Rahmani</au><au>Haznedaroglu, Berat Z.</au><au>Kiraz, Alper</au><au>Tasoglu, Savas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microfluidics for microalgal biotechnology</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol Bioeng</addtitle><date>2021-04</date><risdate>2021</risdate><volume>118</volume><issue>4</issue><spage>1545</spage><epage>1563</epage><pages>1545-1563</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><abstract>Microalgae have expanded their roles as renewable and sustainable feedstocks for biofuel, smart nutrition, biopharmaceutical, cosmeceutical, biosensing, and space technologies. They accumulate valuable biochemical compounds from protein, carbohydrate, and lipid groups, including pigments and carotenoids. Microalgal biomass, which can be adopted for multivalorization under biorefinery settings, allows not only the production of various biofuels but also other value‐added biotechnological products. However, state‐of‐the‐art technologies are required to optimize yield, quality, and the economical aspects of both upstream and downstream processes. As such, the need to use microfluidic‐based devices for both fundamental research and industrial applications of microalgae, arises due to their microscale sizes and dilute cultures. Microfluidics‐based devices are superior to their competitors through their ability to perform multiple functions such as sorting and analyzing small amounts of samples (nanoliter to picoliter) with higher sensitivities. Here, we review emerging applications of microfluidic technologies on microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.
Although microalgae are used widely as biomass feedstocks, only a few hundred of the microalgae have been studied for their high‐value biocompounds and only a small fraction are cultivated industrially. This review by Tasoglu and coworkers highlights key factors and strategies using novel microfluidic platforms to study various microalgal processes in cell sorting, cultivation, harvesting, and applications in biofuels, biosensing, drug delivery, and nutrition.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33410126</pmid><doi>10.1002/bit.27669</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-3883-4065</orcidid><orcidid>https://orcid.org/0000-0002-0081-8801</orcidid><orcidid>https://orcid.org/0000-0003-4604-217X</orcidid><orcidid>https://orcid.org/0000-0001-8888-6106</orcidid><orcidid>https://orcid.org/0000-0001-7977-1286</orcidid><orcidid>https://orcid.org/0000-0003-0113-541X</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0006-3592 |
ispartof | Biotechnology and bioengineering, 2021-04, Vol.118 (4), p.1545-1563 |
issn | 0006-3592 1097-0290 |
language | eng |
recordid | cdi_proquest_miscellaneous_2476125440 |
source | MEDLINE; Wiley Journals |
subjects | Algae Aquatic microorganisms biochemicals Biodiesel fuels Biofuels Biopharmaceuticals Biorefineries biosensing Biosensors Biotechnology Carbohydrates Carotenoids cell harvesting cell sorting Cosmeceuticals Drug delivery Industrial applications Lab-On-A-Chip Devices Lipids microalgae Microalgae - growth & development Microfluidic Analytical Techniques Microfluidics Nutrition Pigments |
title | Microfluidics for microalgal biotechnology |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A52%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microfluidics%20for%20microalgal%20biotechnology&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Ozdalgic,%20Berin&rft.date=2021-04&rft.volume=118&rft.issue=4&rft.spage=1545&rft.epage=1563&rft.pages=1545-1563&rft.issn=0006-3592&rft.eissn=1097-0290&rft_id=info:doi/10.1002/bit.27669&rft_dat=%3Cproquest_cross%3E2501878411%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501878411&rft_id=info:pmid/33410126&rfr_iscdi=true |