Leishmaniasis and Trace Element Alterations: a Systematic Review
Leishmaniasis is a worldwide prevalent parasitic infection caused by different species of the genus Leishmania . Clinically, the disease divided into three main forms, including visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous leishmaniasis (MCL). There is no vaccine for...
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| Veröffentlicht in: | Biological trace element research 2021-10, Vol.199 (10), p.3918-3938 |
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| creator | Taghipour, Ali Abdoli, Amir Ramezani, Afifeh Abolghazi, Ahmad Mofazzal Jahromi, Mirza Ali Maani, Salar Heidar Nejadi, Seyede Manizhe Rasti, Sima Shams, Morteza Ghasemi, Ezatollah |
| description | Leishmaniasis is a worldwide prevalent parasitic infection caused by different species of the genus
Leishmania
. Clinically, the disease divided into three main forms, including visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous leishmaniasis (MCL). There is no vaccine for human leishmaniasis and their treatment is challenging. Trace elements (TEs) alteration, including the selenium (Se), zinc (Zn), copper (Cu), ron (Fe), and magnesium (Mg) have been detected in patients with CL and VL as well as canine leishmaniasis. Because TEs play a pivotal role in the immune system, and host immune responses have crucial roles in defense against leishmaniasis, this systematic review aimed to summarize data regarding TEs alteration in human and animal leishmaniasis as well as the role of these elements as an adjuvant for treatment of leishmaniasis. In a setting of systematic review, we found 29 eligible articles (any date until October 1, 2020) regarding TEs in human CL (
N
= 12), human VL (
N
= 4), canine leishmaniasis (
N
= 3), and treatment of leishmaniasis based on TEs (
N
= 11), which one study examined the TEs level both in CL and VL patients. Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL. In contrast, an increased level of Cu in CL patients and Cu and Mg in VL patients and canine leishmaniasis was observed. Treatment of CL based zinc supplementation revealed enhancement of wound healing and diminished scar formation in human and experimentally infected animals. The results of this systematic review indicate that the TEs have important roles in leishmaniasis, which could be assessed as a prognosis factor in this disease. It is suggested that TEs could be prescribed as an adjuvant for the treatment of CL and VL patients. |
| doi_str_mv | 10.1007/s12011-020-02505-0 |
| format | Article |
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Leishmania
. Clinically, the disease divided into three main forms, including visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous leishmaniasis (MCL). There is no vaccine for human leishmaniasis and their treatment is challenging. Trace elements (TEs) alteration, including the selenium (Se), zinc (Zn), copper (Cu), ron (Fe), and magnesium (Mg) have been detected in patients with CL and VL as well as canine leishmaniasis. Because TEs play a pivotal role in the immune system, and host immune responses have crucial roles in defense against leishmaniasis, this systematic review aimed to summarize data regarding TEs alteration in human and animal leishmaniasis as well as the role of these elements as an adjuvant for treatment of leishmaniasis. In a setting of systematic review, we found 29 eligible articles (any date until October 1, 2020) regarding TEs in human CL (
N
= 12), human VL (
N
= 4), canine leishmaniasis (
N
= 3), and treatment of leishmaniasis based on TEs (
N
= 11), which one study examined the TEs level both in CL and VL patients. Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL. In contrast, an increased level of Cu in CL patients and Cu and Mg in VL patients and canine leishmaniasis was observed. Treatment of CL based zinc supplementation revealed enhancement of wound healing and diminished scar formation in human and experimentally infected animals. The results of this systematic review indicate that the TEs have important roles in leishmaniasis, which could be assessed as a prognosis factor in this disease. It is suggested that TEs could be prescribed as an adjuvant for the treatment of CL and VL patients.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02505-0</identifier><identifier>PMID: 33405078</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Copper ; Cutaneous leishmaniasis ; Disease control ; Dogs ; Humans ; Immune response ; Immune system ; Immunity ; Iron ; Leishmania ; Leishmaniasis, Cutaneous ; Leishmaniasis, Visceral ; Life Sciences ; Magnesium ; Mucocutaneous leishmaniasis ; Nutrition ; Oncology ; Parasitic diseases ; Patients ; Selenium ; Supplements ; Systematic review ; Trace Elements ; Vaccines ; Vector-borne diseases ; Visceral leishmaniasis ; Wound healing ; Zinc</subject><ispartof>Biological trace element research, 2021-10, Vol.199 (10), p.3918-3938</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e77b3616c35965ff57782b32c9cfde5c8099636cd5ac7c143d6a96192e4cada03</citedby><cites>FETCH-LOGICAL-c375t-e77b3616c35965ff57782b32c9cfde5c8099636cd5ac7c143d6a96192e4cada03</cites><orcidid>0000-0003-4326-4586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02505-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02505-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33405078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taghipour, Ali</creatorcontrib><creatorcontrib>Abdoli, Amir</creatorcontrib><creatorcontrib>Ramezani, Afifeh</creatorcontrib><creatorcontrib>Abolghazi, Ahmad</creatorcontrib><creatorcontrib>Mofazzal Jahromi, Mirza Ali</creatorcontrib><creatorcontrib>Maani, Salar</creatorcontrib><creatorcontrib>Heidar Nejadi, Seyede Manizhe</creatorcontrib><creatorcontrib>Rasti, Sima</creatorcontrib><creatorcontrib>Shams, Morteza</creatorcontrib><creatorcontrib>Ghasemi, Ezatollah</creatorcontrib><title>Leishmaniasis and Trace Element Alterations: a Systematic Review</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Leishmaniasis is a worldwide prevalent parasitic infection caused by different species of the genus
Leishmania
. Clinically, the disease divided into three main forms, including visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous leishmaniasis (MCL). There is no vaccine for human leishmaniasis and their treatment is challenging. Trace elements (TEs) alteration, including the selenium (Se), zinc (Zn), copper (Cu), ron (Fe), and magnesium (Mg) have been detected in patients with CL and VL as well as canine leishmaniasis. Because TEs play a pivotal role in the immune system, and host immune responses have crucial roles in defense against leishmaniasis, this systematic review aimed to summarize data regarding TEs alteration in human and animal leishmaniasis as well as the role of these elements as an adjuvant for treatment of leishmaniasis. In a setting of systematic review, we found 29 eligible articles (any date until October 1, 2020) regarding TEs in human CL (
N
= 12), human VL (
N
= 4), canine leishmaniasis (
N
= 3), and treatment of leishmaniasis based on TEs (
N
= 11), which one study examined the TEs level both in CL and VL patients. Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL. In contrast, an increased level of Cu in CL patients and Cu and Mg in VL patients and canine leishmaniasis was observed. Treatment of CL based zinc supplementation revealed enhancement of wound healing and diminished scar formation in human and experimentally infected animals. The results of this systematic review indicate that the TEs have important roles in leishmaniasis, which could be assessed as a prognosis factor in this disease. It is suggested that TEs could be prescribed as an adjuvant for the treatment of CL and VL patients.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Copper</subject><subject>Cutaneous leishmaniasis</subject><subject>Disease control</subject><subject>Dogs</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Iron</subject><subject>Leishmania</subject><subject>Leishmaniasis, Cutaneous</subject><subject>Leishmaniasis, Visceral</subject><subject>Life Sciences</subject><subject>Magnesium</subject><subject>Mucocutaneous leishmaniasis</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Parasitic diseases</subject><subject>Patients</subject><subject>Selenium</subject><subject>Supplements</subject><subject>Systematic review</subject><subject>Trace Elements</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Visceral leishmaniasis</subject><subject>Wound 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and Trace Element Alterations: a Systematic Review</title><author>Taghipour, Ali ; Abdoli, Amir ; Ramezani, Afifeh ; Abolghazi, Ahmad ; Mofazzal Jahromi, Mirza Ali ; Maani, Salar ; Heidar Nejadi, Seyede Manizhe ; Rasti, Sima ; Shams, Morteza ; Ghasemi, Ezatollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e77b3616c35965ff57782b32c9cfde5c8099636cd5ac7c143d6a96192e4cada03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Copper</topic><topic>Cutaneous leishmaniasis</topic><topic>Disease control</topic><topic>Dogs</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Iron</topic><topic>Leishmania</topic><topic>Leishmaniasis, Cutaneous</topic><topic>Leishmaniasis, 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Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taghipour, Ali</au><au>Abdoli, Amir</au><au>Ramezani, Afifeh</au><au>Abolghazi, Ahmad</au><au>Mofazzal Jahromi, Mirza Ali</au><au>Maani, Salar</au><au>Heidar Nejadi, Seyede Manizhe</au><au>Rasti, Sima</au><au>Shams, Morteza</au><au>Ghasemi, Ezatollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leishmaniasis and Trace Element Alterations: a Systematic Review</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>199</volume><issue>10</issue><spage>3918</spage><epage>3938</epage><pages>3918-3938</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Leishmaniasis is a worldwide prevalent parasitic infection caused by different species of the genus
Leishmania
. Clinically, the disease divided into three main forms, including visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous leishmaniasis (MCL). There is no vaccine for human leishmaniasis and their treatment is challenging. Trace elements (TEs) alteration, including the selenium (Se), zinc (Zn), copper (Cu), ron (Fe), and magnesium (Mg) have been detected in patients with CL and VL as well as canine leishmaniasis. Because TEs play a pivotal role in the immune system, and host immune responses have crucial roles in defense against leishmaniasis, this systematic review aimed to summarize data regarding TEs alteration in human and animal leishmaniasis as well as the role of these elements as an adjuvant for treatment of leishmaniasis. In a setting of systematic review, we found 29 eligible articles (any date until October 1, 2020) regarding TEs in human CL (
N
= 12), human VL (
N
= 4), canine leishmaniasis (
N
= 3), and treatment of leishmaniasis based on TEs (
N
= 11), which one study examined the TEs level both in CL and VL patients. Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL. In contrast, an increased level of Cu in CL patients and Cu and Mg in VL patients and canine leishmaniasis was observed. Treatment of CL based zinc supplementation revealed enhancement of wound healing and diminished scar formation in human and experimentally infected animals. The results of this systematic review indicate that the TEs have important roles in leishmaniasis, which could be assessed as a prognosis factor in this disease. It is suggested that TEs could be prescribed as an adjuvant for the treatment of CL and VL patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33405078</pmid><doi>10.1007/s12011-020-02505-0</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0003-4326-4586</orcidid></addata></record> |
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| ispartof | Biological trace element research, 2021-10, Vol.199 (10), p.3918-3938 |
| issn | 0163-4984 1559-0720 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biotechnology Copper Cutaneous leishmaniasis Disease control Dogs Humans Immune response Immune system Immunity Iron Leishmania Leishmaniasis, Cutaneous Leishmaniasis, Visceral Life Sciences Magnesium Mucocutaneous leishmaniasis Nutrition Oncology Parasitic diseases Patients Selenium Supplements Systematic review Trace Elements Vaccines Vector-borne diseases Visceral leishmaniasis Wound healing Zinc |
| title | Leishmaniasis and Trace Element Alterations: a Systematic Review |
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