Salt Engineering of Aripiprazole with Polycarboxylic Acids to Improve Physicochemical Properties

Aripiprazole (APZ) has poor physicochemical properties and bitter taste. The current study aimed to prepare salts of APZ with polycarboxylic acids (citric, malic, and tartaric acids) to improve physicochemical properties and impart sour taste to the drug. The salts were prepared by solubilization-cr...

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Veröffentlicht in:	AAPS PharmSciTech 2021-01, Vol.22 (1), p.31-31, Article 31
Hauptverfasser:	Afrooz, Hamideh, Mohamed, Eman M., Barakh Ali, Sogra F., Dharani, Sathish, Nutan, Mohammad T. H., Khan, Mansoor A., Rahman, Ziyaur
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotic Agents - chemistry Aripiprazole - chemistry Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Calorimetry, Differential Scanning Citric Acid - chemistry Crystallization Drug Stability Malates - chemistry Microscopy, Electron, Scanning Pharmacology/Toxicology Pharmacy Powder Diffraction Research Article Solubility Spectroscopy, Fourier Transform Infrared Tartrates - chemistry
Online-Zugang:	Volltext
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