Photo-induced radical thiol-ene chemistry: a versatile toolbox for peptide-based drug design
While the global market for peptide/protein-based therapeutics is witnessing significant growth, the development of peptide drugs remains challenging due to their low oral bioavailability, poor membrane permeability, and reduced metabolic stability. However, a toolbox of chemical approaches has been...
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| Veröffentlicht in: | Chemical Society reviews 2021-01, Vol.5 (2), p.898-944 |
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| creator | Ahangarpour, Marzieh Kavianinia, Iman Harris, Paul W. R Brimble, Margaret A |
| description | While the global market for peptide/protein-based therapeutics is witnessing significant growth, the development of peptide drugs remains challenging due to their low oral bioavailability, poor membrane permeability, and reduced metabolic stability. However, a toolbox of chemical approaches has been explored for peptide modification to overcome these obstacles. In recent years, there has been a revival of interest in photoinduced radical thiol-ene chemistry as a powerful tool for the construction of therapeutic peptides.
Thiol-ene chemistry, a tailored approach to access novel peptide-based drugs. |
| doi_str_mv | 10.1039/d0cs00354a |
| format | Article |
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| ispartof | Chemical Society reviews, 2021-01, Vol.5 (2), p.898-944 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Bioavailability Global marketing Peptides |
| title | Photo-induced radical thiol-ene chemistry: a versatile toolbox for peptide-based drug design |
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