Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study
Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. To determine the incidence of cognitive impairment and dementia in people with and without a COPD...
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| Veröffentlicht in: | Respiratory medicine 2021-02, Vol.177, p.106288-106288, Article 106288 |
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| creator | Siraj, R.A. McKeever, T.M. Gibson, J.E. Gordon, A.L. Bolton, C.E. |
| description | Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive.
To determine the incidence of cognitive impairment and dementia in people with and without a COPD diagnosis.
A population-based study using UK General Practice (GP) health records from The Health Improvement Network database was conducted. Patients with confirmed COPD diagnosis, ≥40 years old, were matched to up to four subjects without a COPD diagnosis by age, sex and GP practice. Cox proportional hazards models were used to assess the incidence rates of cognitive impairment and dementia.
Of patients with COPD (n = 62,148), 9% developed cognitive impairment, compared with 7% of subjects without COPD (n = 230,076), p |
| doi_str_mv | 10.1016/j.rmed.2020.106288 |
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To determine the incidence of cognitive impairment and dementia in people with and without a COPD diagnosis.
A population-based study using UK General Practice (GP) health records from The Health Improvement Network database was conducted. Patients with confirmed COPD diagnosis, ≥40 years old, were matched to up to four subjects without a COPD diagnosis by age, sex and GP practice. Cox proportional hazards models were used to assess the incidence rates of cognitive impairment and dementia.
Of patients with COPD (n = 62,148), 9% developed cognitive impairment, compared with 7% of subjects without COPD (n = 230,076), p < 0.001. The incidence of cognitive impairment following COPD diagnosis was greater than in subjects without COPD following index date (adjusted Hazard Ratio (aHR), 1.21; 95% CI: 1.16 ─ 1.26, p < 0.001). The coded incidence of either cognitive impairment or dementia was also greater in patients with COPD following adjustment for confounders (aHR: 1.13, 95% CI: 1.09 ─ 1.18, p < 0.001). Coded incident dementia alone was not different between patients with COPD and subjects without COPD (aHR, 0.91, 95% CI: 0.83 ─ 1.01, p = 0.053).
Despite the increased incidence of cognitive impairment in patients with COPD, incidence of dementia was not as frequently recorded in patients with COPD. This raises the concern of undiagnosed dementia and emphasises the need for a systematic assessment in this population.
•Estimating the proportion of patients with COPD who have impaired cognitive state helps understand the burden of COPD.•The incidence of cognitive impairment is greater in patients with COPD compared to those without.•There is likely underdiagnosis of dementia in patients with COPD.•A systematic cognitive assessment for patients with COPD should be considered.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2020.106288</identifier><identifier>PMID: 33401149</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age ; Chronic obstructive pulmonary disease ; Cognitive ability ; Cognitive impairment ; Comorbidity ; COPD ; Dementia ; Dementia disorders ; Diagnosis ; Dyspnea ; Gender ; Hazard assessment ; Health hazards ; Impairment ; Indexing ; Lung diseases ; Obstructive lung disease ; Patients ; Population ; Population studies ; Population-based studies ; Statistical models</subject><ispartof>Respiratory medicine, 2021-02, Vol.177, p.106288-106288, Article 106288</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-a285451cdec8237793cad4709e566d5c5a04683456f6af2b4a23a8bbbf9546853</citedby><cites>FETCH-LOGICAL-c428t-a285451cdec8237793cad4709e566d5c5a04683456f6af2b4a23a8bbbf9546853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2020.106288$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33401149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siraj, R.A.</creatorcontrib><creatorcontrib>McKeever, T.M.</creatorcontrib><creatorcontrib>Gibson, J.E.</creatorcontrib><creatorcontrib>Gordon, A.L.</creatorcontrib><creatorcontrib>Bolton, C.E.</creatorcontrib><title>Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive.
To determine the incidence of cognitive impairment and dementia in people with and without a COPD diagnosis.
A population-based study using UK General Practice (GP) health records from The Health Improvement Network database was conducted. Patients with confirmed COPD diagnosis, ≥40 years old, were matched to up to four subjects without a COPD diagnosis by age, sex and GP practice. Cox proportional hazards models were used to assess the incidence rates of cognitive impairment and dementia.
Of patients with COPD (n = 62,148), 9% developed cognitive impairment, compared with 7% of subjects without COPD (n = 230,076), p < 0.001. The incidence of cognitive impairment following COPD diagnosis was greater than in subjects without COPD following index date (adjusted Hazard Ratio (aHR), 1.21; 95% CI: 1.16 ─ 1.26, p < 0.001). The coded incidence of either cognitive impairment or dementia was also greater in patients with COPD following adjustment for confounders (aHR: 1.13, 95% CI: 1.09 ─ 1.18, p < 0.001). Coded incident dementia alone was not different between patients with COPD and subjects without COPD (aHR, 0.91, 95% CI: 0.83 ─ 1.01, p = 0.053).
Despite the increased incidence of cognitive impairment in patients with COPD, incidence of dementia was not as frequently recorded in patients with COPD. This raises the concern of undiagnosed dementia and emphasises the need for a systematic assessment in this population.
•Estimating the proportion of patients with COPD who have impaired cognitive state helps understand the burden of COPD.•The incidence of cognitive impairment is greater in patients with COPD compared to those without.•There is likely underdiagnosis of dementia in patients with COPD.•A systematic cognitive assessment for patients with COPD should be considered.</description><subject>Age</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cognitive ability</subject><subject>Cognitive impairment</subject><subject>Comorbidity</subject><subject>COPD</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Diagnosis</subject><subject>Dyspnea</subject><subject>Gender</subject><subject>Hazard assessment</subject><subject>Health hazards</subject><subject>Impairment</subject><subject>Indexing</subject><subject>Lung diseases</subject><subject>Obstructive lung disease</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Statistical models</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS0EoreFF2CBLLEpi1z8HwexqS7lR1QqQnRtObbT-pLYwXaK-hy8MA633bBgNaOZb45G5wDwAqMtRli82W_T5OyWILIOBJHyEdhgTklDkWCPwQZ1nDUCY3wEjnPeI4Q6xtBTcEQpQxizbgN-f_P5B4wD9MF460KB1k21eA11sNDE6-CLv3XQT7P2aV1VFM66-Npm-MuXG2huUgzewNjnkhbzl5-XcYpBpztofXY6O3i6u_z6_vVbeAZHna4dvPoC51ixKhVD01fEwlwWe_cMPBn0mN3z-3oCrj6cf999ai4uP37enV00hhFZGk0kZxwb64wktG07arRlLeocF8JywzViQlLGxSD0QHqmCdWy7_uh2iIkpyfg9KA7p_hzcbmoyWfjxlEHF5esCGs5p7htUUVf_YPu45JC_a5SHSFCtoxUihwok2LOyQ1qTn6qHiiM1BqZ2qs1MrVGpg6R1aOX99JLv-4eTh4yqsC7A-CqF7feJZVNNd8465MzRdno_6f_B6HbqDY</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Siraj, R.A.</creator><creator>McKeever, T.M.</creator><creator>Gibson, J.E.</creator><creator>Gordon, A.L.</creator><creator>Bolton, C.E.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study</title><author>Siraj, R.A. ; McKeever, T.M. ; Gibson, J.E. ; Gordon, A.L. ; Bolton, C.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-a285451cdec8237793cad4709e566d5c5a04683456f6af2b4a23a8bbbf9546853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cognitive ability</topic><topic>Cognitive impairment</topic><topic>Comorbidity</topic><topic>COPD</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Diagnosis</topic><topic>Dyspnea</topic><topic>Gender</topic><topic>Hazard assessment</topic><topic>Health hazards</topic><topic>Impairment</topic><topic>Indexing</topic><topic>Lung diseases</topic><topic>Obstructive lung disease</topic><topic>Patients</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Statistical models</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siraj, R.A.</creatorcontrib><creatorcontrib>McKeever, T.M.</creatorcontrib><creatorcontrib>Gibson, J.E.</creatorcontrib><creatorcontrib>Gordon, A.L.</creatorcontrib><creatorcontrib>Bolton, C.E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siraj, R.A.</au><au>McKeever, T.M.</au><au>Gibson, J.E.</au><au>Gordon, A.L.</au><au>Bolton, C.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>177</volume><spage>106288</spage><epage>106288</epage><pages>106288-106288</pages><artnum>106288</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive.
To determine the incidence of cognitive impairment and dementia in people with and without a COPD diagnosis.
A population-based study using UK General Practice (GP) health records from The Health Improvement Network database was conducted. Patients with confirmed COPD diagnosis, ≥40 years old, were matched to up to four subjects without a COPD diagnosis by age, sex and GP practice. Cox proportional hazards models were used to assess the incidence rates of cognitive impairment and dementia.
Of patients with COPD (n = 62,148), 9% developed cognitive impairment, compared with 7% of subjects without COPD (n = 230,076), p < 0.001. The incidence of cognitive impairment following COPD diagnosis was greater than in subjects without COPD following index date (adjusted Hazard Ratio (aHR), 1.21; 95% CI: 1.16 ─ 1.26, p < 0.001). The coded incidence of either cognitive impairment or dementia was also greater in patients with COPD following adjustment for confounders (aHR: 1.13, 95% CI: 1.09 ─ 1.18, p < 0.001). Coded incident dementia alone was not different between patients with COPD and subjects without COPD (aHR, 0.91, 95% CI: 0.83 ─ 1.01, p = 0.053).
Despite the increased incidence of cognitive impairment in patients with COPD, incidence of dementia was not as frequently recorded in patients with COPD. This raises the concern of undiagnosed dementia and emphasises the need for a systematic assessment in this population.
•Estimating the proportion of patients with COPD who have impaired cognitive state helps understand the burden of COPD.•The incidence of cognitive impairment is greater in patients with COPD compared to those without.•There is likely underdiagnosis of dementia in patients with COPD.•A systematic cognitive assessment for patients with COPD should be considered.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33401149</pmid><doi>10.1016/j.rmed.2020.106288</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Chronic obstructive pulmonary disease Cognitive ability Cognitive impairment Comorbidity COPD Dementia Dementia disorders Diagnosis Dyspnea Gender Hazard assessment Health hazards Impairment Indexing Lung diseases Obstructive lung disease Patients Population Population studies Population-based studies Statistical models |
| title | Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study |
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