New insight into the role of isorhamnetin as a regulator of insulin signaling pathway in type 2 diabetes mellitus rat model: Molecular and computational approach

[Display omitted] •IHN is a plant flavonoid with anti-diabetic properties.•We assessed the insulin resistance lowering effects of IHN in T2DM rat.•IHN resulted in restoration of myofibrils and adipose tissue architecture.•IHN down regulates mTOR,IGF1-R & LncRNA-RP11-773H22.4 expression.•IHN up-r...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-03, Vol.135, p.111176-111176, Article 111176
Hauptverfasser:	Matboli, Marwa, Saad, Maha, Hasanin, Amany Helmy, A. Saleh, Lobna, Baher, Walaa, Bekhet, Miram M., Eissa, Sanaa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - pathology Animals Bioinformatics Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - pathology Hypoglycemic Agents - pharmacology Insulin - blood Insulin Resistance Isorhamnetin Male MicroRNAs - genetics MicroRNAs - metabolism Myofibrils - drug effects Myofibrils - metabolism Myofibrils - pathology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Quercetin - analogs & derivatives Quercetin - pharmacology Rats Rats, Wistar Receptor, IGF Type 1 - metabolism RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism Type 2 diabetes mellitus
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