Robust parameter design of human induced pluripotent stem cell differentiation protocols defines lineage‐specific induction of anterior‐posterior gut tube endodermal cells

Tissues and cells derived from pluripotent stem cells (PSC) are likely to become widely used in disease modeling, drug screening, and regenerative medicine. For these applications, the in vitro PSC differentiation process must be elaborately investigated and controlled to reliably obtain the desired...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2021-04, Vol.39 (4), p.429-442
Hauptverfasser:	Yasui, Ryota, Sekine, Keisuke, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Taniguchi, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptability anterior‐posterior patterning Cell culture Cell differentiation Design Design of experiments design of experiments (DOE) Design parameters Differentiation (biology) Drug screening endoderm Experimental methods Foregut Gene expression Hindgut induced pluripotent stem cells Kinases Mass production Optimization Pancreas Parameter robustness Pluripotency pluripotent stem cells Regenerative medicine Robustness Screening Signal transduction Signaling Stem cells Tissue engineering
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