LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway

Our results demonstrated that LHPP suppressed ICC tumorigenesis through inhibiting the TGFβ/smad signaling pathway. [Display omitted] •LHPP was downregulated in ICC and predicted poor survival.•As a tumor suppressor, LHPP inhibited ICC cell growth, cell invasion and EMT in vitro and in vivo.•LHPP su...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2021-03, Vol.132, p.105845, Article 105845
Hauptverfasser:	Wang, Dan, Ning, Zhouyu, Zhu, Zhenfeng, Zhang, Chenyue, Wang, Peng, Meng, Zhiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell Line, Tumor Cell Proliferation Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Epithelial-Mesenchymal Transition - drug effects Epithelial–mesenchymal transition Female Gene Expression Regulation, Neoplastic Humans Inorganic Pyrophosphatase - genetics Inorganic Pyrophosphatase - metabolism Intrahepatic cholangiocarcinoma LHPP Male Mice Mice, Inbred BALB C Mice, Nude Middle Aged Signal Transduction - drug effects Smad Proteins - metabolism Smad2 Protein - genetics Smad2 Protein - metabolism Transforming Growth Factor beta - metabolism Transforming growth factor‑beta (TGFβ)
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