Boundary-Condition Analysis of an Idealized Left Atrium Model
The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised by irregular and ineffective atrial contraction. This behaviour results into the formation of thrombi, mainly in the left atrial appendage (LAA), responsible for thromboembolic events. Very different appro...
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| Veröffentlicht in: | Annals of biomedical engineering 2021-06, Vol.49 (6), p.1507-1520 |
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| creator | Dueñas-Pamplona, Jorge Sierra-Pallares, José García, Javier Castro, Francisco Munoz-Paniagua, Jorge |
| description | The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised by irregular and ineffective atrial contraction. This behaviour results into the formation of thrombi, mainly in the left atrial appendage (LAA), responsible for thromboembolic events. Very different approaches are considered as therapy for AF patients. Therefore, it is necessary to yield insight into the flow physics of thrombi formation to determine which is the most appropriate strategy in each case. Computational Fluid Dynamics (CFD) has proven successful in getting a better understanding of the thrombosis phenomenon, but it still requires validation by means of accurate flow field
in vivo
atrial measurements. As an alternative, in this paper it is proposed an
in vitro
flow validation, consisting in an idealised model that captures the main flow features observed in the human LA which, once combined with Particle Image Velocimetry (PIV) measurements, provides readily accessible, easy to emulate, detailed velocity fields. These results have been used to validate our laminar and Large Eddy Simulation (LES) simulations. Besides, we have run a parametric study of different boundary conditions sets previously employed in the literature. These data can be used as a benchmark for further development of LA CFD models. |
| doi_str_mv | 10.1007/s10439-020-02702-x |
| format | Article |
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in vivo
atrial measurements. As an alternative, in this paper it is proposed an
in vitro
flow validation, consisting in an idealised model that captures the main flow features observed in the human LA which, once combined with Particle Image Velocimetry (PIV) measurements, provides readily accessible, easy to emulate, detailed velocity fields. These results have been used to validate our laminar and Large Eddy Simulation (LES) simulations. Besides, we have run a parametric study of different boundary conditions sets previously employed in the literature. These data can be used as a benchmark for further development of LA CFD models.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-020-02702-x</identifier><identifier>PMID: 33403454</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Arrhythmia ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Boundary conditions ; Classical Mechanics ; Computational fluid dynamics ; Computer applications ; Contraction ; Fibrillation ; Fluid dynamics ; Hydrodynamics ; Large eddy simulation ; Mathematical models ; Original Article ; Particle image velocimetry ; Thromboembolism ; Thrombosis ; Velocity distribution</subject><ispartof>Annals of biomedical engineering, 2021-06, Vol.49 (6), p.1507-1520</ispartof><rights>Biomedical Engineering Society 2021</rights><rights>Biomedical Engineering Society 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-93fe2355ac3dada6b596aed43d88dd688c33f37093d9d589574489f2d3fd33ae3</citedby><cites>FETCH-LOGICAL-c375t-93fe2355ac3dada6b596aed43d88dd688c33f37093d9d589574489f2d3fd33ae3</cites><orcidid>0000-0002-7038-7517 ; 0000-0002-2986-7228 ; 0000-0002-4450-2438 ; 0000-0003-1565-9337 ; 0000-0002-6570-6624</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-020-02702-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-020-02702-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33403454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dueñas-Pamplona, Jorge</creatorcontrib><creatorcontrib>Sierra-Pallares, José</creatorcontrib><creatorcontrib>García, Javier</creatorcontrib><creatorcontrib>Castro, Francisco</creatorcontrib><creatorcontrib>Munoz-Paniagua, Jorge</creatorcontrib><title>Boundary-Condition Analysis of an Idealized Left Atrium Model</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised by irregular and ineffective atrial contraction. This behaviour results into the formation of thrombi, mainly in the left atrial appendage (LAA), responsible for thromboembolic events. Very different approaches are considered as therapy for AF patients. Therefore, it is necessary to yield insight into the flow physics of thrombi formation to determine which is the most appropriate strategy in each case. Computational Fluid Dynamics (CFD) has proven successful in getting a better understanding of the thrombosis phenomenon, but it still requires validation by means of accurate flow field
in vivo
atrial measurements. As an alternative, in this paper it is proposed an
in vitro
flow validation, consisting in an idealised model that captures the main flow features observed in the human LA which, once combined with Particle Image Velocimetry (PIV) measurements, provides readily accessible, easy to emulate, detailed velocity fields. These results have been used to validate our laminar and Large Eddy Simulation (LES) simulations. Besides, we have run a parametric study of different boundary conditions sets previously employed in the literature. These data can be used as a benchmark for further development of LA CFD models.</description><subject>Arrhythmia</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Boundary conditions</subject><subject>Classical Mechanics</subject><subject>Computational fluid dynamics</subject><subject>Computer applications</subject><subject>Contraction</subject><subject>Fibrillation</subject><subject>Fluid dynamics</subject><subject>Hydrodynamics</subject><subject>Large eddy simulation</subject><subject>Mathematical models</subject><subject>Original Article</subject><subject>Particle image velocimetry</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Velocity 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Eng</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>49</volume><issue>6</issue><spage>1507</spage><epage>1520</epage><pages>1507-1520</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised by irregular and ineffective atrial contraction. This behaviour results into the formation of thrombi, mainly in the left atrial appendage (LAA), responsible for thromboembolic events. Very different approaches are considered as therapy for AF patients. Therefore, it is necessary to yield insight into the flow physics of thrombi formation to determine which is the most appropriate strategy in each case. Computational Fluid Dynamics (CFD) has proven successful in getting a better understanding of the thrombosis phenomenon, but it still requires validation by means of accurate flow field
in vivo
atrial measurements. As an alternative, in this paper it is proposed an
in vitro
flow validation, consisting in an idealised model that captures the main flow features observed in the human LA which, once combined with Particle Image Velocimetry (PIV) measurements, provides readily accessible, easy to emulate, detailed velocity fields. These results have been used to validate our laminar and Large Eddy Simulation (LES) simulations. Besides, we have run a parametric study of different boundary conditions sets previously employed in the literature. These data can be used as a benchmark for further development of LA CFD models.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33403454</pmid><doi>10.1007/s10439-020-02702-x</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7038-7517</orcidid><orcidid>https://orcid.org/0000-0002-2986-7228</orcidid><orcidid>https://orcid.org/0000-0002-4450-2438</orcidid><orcidid>https://orcid.org/0000-0003-1565-9337</orcidid><orcidid>https://orcid.org/0000-0002-6570-6624</orcidid></addata></record> |
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| subjects | Arrhythmia Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Boundary conditions Classical Mechanics Computational fluid dynamics Computer applications Contraction Fibrillation Fluid dynamics Hydrodynamics Large eddy simulation Mathematical models Original Article Particle image velocimetry Thromboembolism Thrombosis Velocity distribution |
| title | Boundary-Condition Analysis of an Idealized Left Atrium Model |
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