Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments

Histidine decarboxylase (HDC), a histamine synthase, is expressed in various hematopoietic cells and is induced by hematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF). We previously showed that nitrogen-containing bisphosphonate (NBP)-treatment induces extramedullary hemato...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of hematology 2021-03, Vol.113 (3), p.348-361
Hauptverfasser:	Otsuka, Hirotada, Endo, Yasuo, Ohtsu, Hiroshi, Inoue, Satoshi, Noguchi, Syunya, Nakamura, Masanori, Soeta, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Bone marrow Bone morphogenetic protein 4 Cells (biology) Chemokines Colony-stimulating factor CXC chemokines CXCL12 protein Cytokines Erythropoiesis Gene expression Granulocyte colony-stimulating factor Hematology Hematopoiesis Hematopoietic stem cells Histamine Histidine Histidine decarboxylase Hypoxia Hypoxia-inducible factor 1 Leukocytes (granulocytic) Macrophages Medicine Medicine & Public Health Microenvironments Oncology Original Article Progenitor cells Rodents Spleen Vascular cell adhesion molecule 1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!