Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates

A detailed understanding of intestinal stem cell (ISC) self-renewal and differentiation is required to treat chronic intestinal diseases. However, the different models of ISC lineage hierarchy 1 – 6 and segregation 7 – 12 are subject to debate. Here, we have discovered non-canonical Wnt/planar cell...

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Veröffentlicht in:	Nature cell biology 2021-01, Vol.23 (1), p.23-31
Hauptverfasser:	Böttcher, Anika, Büttner, Maren, Tritschler, Sophie, Sterr, Michael, Aliluev, Alexandra, Oppenländer, Lena, Burtscher, Ingo, Sass, Steffen, Irmler, Martin, Beckers, Johannes, Ziegenhain, Christoph, Enard, Wolfgang, Schamberger, Andrea C., Verhamme, Fien M., Eickelberg, Oliver, Theis, Fabian J., Lickert, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/31 38/91 631/114 631/532 64 64/60 Animals beta Catenin - metabolism Biological control systems Biomedical and Life Sciences Cancer Research Cell Biology Cell differentiation Cell fate Cell Lineage Cell Polarity Cell Self Renewal Cellular signal transduction Developmental Biology Enteroendocrine Cells - cytology Enteroendocrine Cells - metabolism Female Gene expression Gene Expression Profiling Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine Intestines Labeling Letter Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Observations Paneth cells Paneth Cells - cytology Paneth Cells - metabolism Physiological aspects Polarity Post-transcription Priming Receptors, G-Protein-Coupled - physiology Signal transduction Signaling Single-Cell Analysis Stem cell transplantation Stem Cells Stem Cells - cytology Stem Cells - metabolism Wnt protein Wnt proteins Wnt Proteins - metabolism β-Catenin
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