Correlation between Depression Severity and Thiol Disulfide Homeostasis in Patients undergoing Hemodialysis
To investigate the correlation between depression severity and oxidative stress in patients undergoing hemodialysis (HD) using thiol disulfide homeostasis (TDH). Descriptive, analytical study. Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020. A total of 6...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2020-12, Vol.30 (12), p.1273-1278 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Kurku, Hüseyin Gederet, Yavuz Turgut Bor, Mehmet Akif Güney, Ibrahim Neşelioğlu, Salim Biyik, Zeynep |
| description | To investigate the correlation between depression severity and oxidative stress in patients undergoing hemodialysis (HD) using thiol disulfide homeostasis (TDH).
Descriptive, analytical study.
Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020.
A total of 67 patients including 35 males (52.2%) and 32 females (47.8%), receiving HD treatment, were included in the study. The Hamilton depression rating scale (HAM-D) was applied to the participants. Thiol disulfide homeostasis (total thiol (TT), native thiol (NT), disulfide, disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio) parameters, albumin, and ischemia modified albumin (IMA) levels were determined. The study groups were investigated by dividing them into groups according to their gender and HAM-D score.
According to HAM-D score, there were 32 (47.8%) patients with depression symptom (DS, HAM-D score of ≥8) and 35 (52.2%) patients without DS (HAM-D score: 0-7). Modified Charlson comorbidity index (MCCI), disulfide, disulfide/NT%, and disulfide/TT% levels were statistically and significantly higher and NT/TT% was statistically and significantly lower in DS group than the values of the groups without DS (p = 0.003, p =0.043, p = 0.017, p=0.017 and p = 0.017, respectively). HAM-D score and MCCI were statistically and significantly higher in females than males (p |
| doi_str_mv | 10.29271/jcpsp.2020.12.1273 |
| format | Article |
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Descriptive, analytical study.
Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020.
A total of 67 patients including 35 males (52.2%) and 32 females (47.8%), receiving HD treatment, were included in the study. The Hamilton depression rating scale (HAM-D) was applied to the participants. Thiol disulfide homeostasis (total thiol (TT), native thiol (NT), disulfide, disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio) parameters, albumin, and ischemia modified albumin (IMA) levels were determined. The study groups were investigated by dividing them into groups according to their gender and HAM-D score.
According to HAM-D score, there were 32 (47.8%) patients with depression symptom (DS, HAM-D score of ≥8) and 35 (52.2%) patients without DS (HAM-D score: 0-7). Modified Charlson comorbidity index (MCCI), disulfide, disulfide/NT%, and disulfide/TT% levels were statistically and significantly higher and NT/TT% was statistically and significantly lower in DS group than the values of the groups without DS (p = 0.003, p =0.043, p = 0.017, p=0.017 and p = 0.017, respectively). HAM-D score and MCCI were statistically and significantly higher in females than males (p <0.001, p = 0.001, respectively). While, 21 patients (65.6%) had DS in women; according to HAM-D score, this rate was found to be statistically higher than men (11 patients, 31.4%, p = 0.005).
Almost half of HD patients had at least moderate depression symptoms. In the group of HD patients with DS, TDH shifted in the oxidative direction. This may contribute to the future studies in enlightening depression etiology in HD patients. Key Words: Hemodialysis, Depression, Thiol disulfide homeostasis (TDH), IMA.</description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>DOI: 10.29271/jcpsp.2020.12.1273</identifier><identifier>PMID: 33397052</identifier><language>eng</language><publisher>Pakistan: College of Physicians and Surgeons Pakistan</publisher><subject>Depression, Mental ; Health aspects ; Hemodialysis patients ; Homeostasis ; Measurement ; Oxidative stress ; Psychological aspects ; Risk factors ; Thiols</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2020-12, Vol.30 (12), p.1273-1278</ispartof><rights>COPYRIGHT 2020 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33397052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurku, Hüseyin</creatorcontrib><creatorcontrib>Gederet, Yavuz Turgut</creatorcontrib><creatorcontrib>Bor, Mehmet Akif</creatorcontrib><creatorcontrib>Güney, Ibrahim</creatorcontrib><creatorcontrib>Neşelioğlu, Salim</creatorcontrib><creatorcontrib>Biyik, Zeynep</creatorcontrib><title>Correlation between Depression Severity and Thiol Disulfide Homeostasis in Patients undergoing Hemodialysis</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>To investigate the correlation between depression severity and oxidative stress in patients undergoing hemodialysis (HD) using thiol disulfide homeostasis (TDH).
Descriptive, analytical study.
Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020.
A total of 67 patients including 35 males (52.2%) and 32 females (47.8%), receiving HD treatment, were included in the study. The Hamilton depression rating scale (HAM-D) was applied to the participants. Thiol disulfide homeostasis (total thiol (TT), native thiol (NT), disulfide, disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio) parameters, albumin, and ischemia modified albumin (IMA) levels were determined. The study groups were investigated by dividing them into groups according to their gender and HAM-D score.
According to HAM-D score, there were 32 (47.8%) patients with depression symptom (DS, HAM-D score of ≥8) and 35 (52.2%) patients without DS (HAM-D score: 0-7). Modified Charlson comorbidity index (MCCI), disulfide, disulfide/NT%, and disulfide/TT% levels were statistically and significantly higher and NT/TT% was statistically and significantly lower in DS group than the values of the groups without DS (p = 0.003, p =0.043, p = 0.017, p=0.017 and p = 0.017, respectively). HAM-D score and MCCI were statistically and significantly higher in females than males (p <0.001, p = 0.001, respectively). While, 21 patients (65.6%) had DS in women; according to HAM-D score, this rate was found to be statistically higher than men (11 patients, 31.4%, p = 0.005).
Almost half of HD patients had at least moderate depression symptoms. In the group of HD patients with DS, TDH shifted in the oxidative direction. This may contribute to the future studies in enlightening depression etiology in HD patients. Key Words: Hemodialysis, Depression, Thiol disulfide homeostasis (TDH), IMA.</description><subject>Depression, Mental</subject><subject>Health aspects</subject><subject>Hemodialysis patients</subject><subject>Homeostasis</subject><subject>Measurement</subject><subject>Oxidative stress</subject><subject>Psychological aspects</subject><subject>Risk factors</subject><subject>Thiols</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkV1rFDEUhoMotlZ_gVAC3vRm1nxMJpPLsv1YoaBgBe9CJjmzpp1JxmSmZf99s90qCJJwTjg87yHwIPSRkhVTTNLPd3bK04oRRlaUlSv5K3RMm5ZWstTX5U0Yq3jb_DxC73K-I4QL2rZv0RHnXEki2DG6X8eUYDCzjwF3MD8CBHwBU4Kc96Pv8ADJzztsgsO3v3wc8IXPy9B7B3gTR4h5Ntln7AP-VrZAmDNegoO0jT5s8QbG6LwZdoV5j970Zsjw4aWfoB9Xl7frTXXz9frL-vymsryRcyVaZbjsWylNqUzavjHQ1Z1logYwHQGnbOca1dTKgiBOtF3NKVUgOG-d4yfo7LB3SvH3AnnWo88WhsEEiEvWrJaCK6WkKuinA7o1A2gf-jgnY_e4Pm8EVURSQQq1-g9VjoPR2xig92X-T4AfAjbFnBP0ekp-NGmnKdHP8vSzPL2XpynTe3kldfry76Ubwf3N_LHFnwCfeJfX</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Kurku, Hüseyin</creator><creator>Gederet, Yavuz Turgut</creator><creator>Bor, Mehmet Akif</creator><creator>Güney, Ibrahim</creator><creator>Neşelioğlu, Salim</creator><creator>Biyik, Zeynep</creator><general>College of Physicians and Surgeons Pakistan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Correlation between Depression Severity and Thiol Disulfide Homeostasis in Patients undergoing Hemodialysis</title><author>Kurku, Hüseyin ; Gederet, Yavuz Turgut ; Bor, Mehmet Akif ; Güney, Ibrahim ; Neşelioğlu, Salim ; Biyik, Zeynep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-589a37f877a7f827cf6aeb4bc254eeab0ed9cbd69649ce50d58b43119e5338dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Depression, Mental</topic><topic>Health aspects</topic><topic>Hemodialysis patients</topic><topic>Homeostasis</topic><topic>Measurement</topic><topic>Oxidative stress</topic><topic>Psychological aspects</topic><topic>Risk factors</topic><topic>Thiols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurku, Hüseyin</creatorcontrib><creatorcontrib>Gederet, Yavuz Turgut</creatorcontrib><creatorcontrib>Bor, Mehmet Akif</creatorcontrib><creatorcontrib>Güney, Ibrahim</creatorcontrib><creatorcontrib>Neşelioğlu, Salim</creatorcontrib><creatorcontrib>Biyik, Zeynep</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurku, Hüseyin</au><au>Gederet, Yavuz Turgut</au><au>Bor, Mehmet Akif</au><au>Güney, Ibrahim</au><au>Neşelioğlu, Salim</au><au>Biyik, Zeynep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Depression Severity and Thiol Disulfide Homeostasis in Patients undergoing Hemodialysis</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2020-12</date><risdate>2020</risdate><volume>30</volume><issue>12</issue><spage>1273</spage><epage>1278</epage><pages>1273-1278</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>To investigate the correlation between depression severity and oxidative stress in patients undergoing hemodialysis (HD) using thiol disulfide homeostasis (TDH).
Descriptive, analytical study.
Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020.
A total of 67 patients including 35 males (52.2%) and 32 females (47.8%), receiving HD treatment, were included in the study. The Hamilton depression rating scale (HAM-D) was applied to the participants. Thiol disulfide homeostasis (total thiol (TT), native thiol (NT), disulfide, disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio) parameters, albumin, and ischemia modified albumin (IMA) levels were determined. The study groups were investigated by dividing them into groups according to their gender and HAM-D score.
According to HAM-D score, there were 32 (47.8%) patients with depression symptom (DS, HAM-D score of ≥8) and 35 (52.2%) patients without DS (HAM-D score: 0-7). Modified Charlson comorbidity index (MCCI), disulfide, disulfide/NT%, and disulfide/TT% levels were statistically and significantly higher and NT/TT% was statistically and significantly lower in DS group than the values of the groups without DS (p = 0.003, p =0.043, p = 0.017, p=0.017 and p = 0.017, respectively). HAM-D score and MCCI were statistically and significantly higher in females than males (p <0.001, p = 0.001, respectively). While, 21 patients (65.6%) had DS in women; according to HAM-D score, this rate was found to be statistically higher than men (11 patients, 31.4%, p = 0.005).
Almost half of HD patients had at least moderate depression symptoms. In the group of HD patients with DS, TDH shifted in the oxidative direction. This may contribute to the future studies in enlightening depression etiology in HD patients. Key Words: Hemodialysis, Depression, Thiol disulfide homeostasis (TDH), IMA.</abstract><cop>Pakistan</cop><pub>College of Physicians and Surgeons Pakistan</pub><pmid>33397052</pmid><doi>10.29271/jcpsp.2020.12.1273</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Depression, Mental Health aspects Hemodialysis patients Homeostasis Measurement Oxidative stress Psychological aspects Risk factors Thiols |
| title | Correlation between Depression Severity and Thiol Disulfide Homeostasis in Patients undergoing Hemodialysis |
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