UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy

Objectives To evaluate the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients and to compare the sodium valproate concentration in different patterns of UGT gene polymorphism. Methods In this cross-sectional study, 99 pediatric epileptic patients aged 2–18 y receiving Sod...

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Veröffentlicht in:	Indian journal of pediatrics 2021-08, Vol.88 (8), p.764-770
Hauptverfasser:	Nandith, P. B., Adiga, Usha, Shenoy, Vijaya, Adiga M N, Sachidananda
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - therapeutic use Child Cross-Sectional Studies Glucuronosyltransferase - genetics Gynecology Humans Medicine Medicine & Public Health Original Article Pediatrics Polymorphism, Single Nucleotide Valproic Acid - therapeutic use
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Zusammenfassung:	Objectives To evaluate the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients and to compare the sodium valproate concentration in different patterns of UGT gene polymorphism. Methods In this cross-sectional study, 99 pediatric epileptic patients aged 2–18 y receiving Sodium valproate monotherapy for the past one month were included from JusticeK S Hegde Charitable hospital, Mangalore after obtaining informed consent. Genetic polymorphism patterns were evaluated by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Trough level serum valproate concentration was estimated by high-performance liquid chromatography (HPLC). Sodium valproate concentration in different UGT genotypes was compared by Analysis of Variance (ANOVA). P value
ISSN:	0019-5456 0973-7693
DOI:	10.1007/s12098-020-03565-9