The Effect of Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors on Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease

Purpose Circulating endothelial progenitor cells (cEPCs) are vital to vascular repair by re-endothelialization. We aimed to explore the effect of proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) on cEPCs hypothesizing a possible pleiotropic effect. Methods Patients with cardiovascul...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2022-02, Vol.36 (1), p.85-92
Hauptverfasser:	Itzhaki Ben Zadok, Osnat, Mager, Aviv, Leshem-Lev, Dorit, Lev, Eli, Kornowski, Ran, Eisen, Alon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology CD34 antigen Cells (biology) Cholesterol Cholesterol, LDL - blood Cohort Studies Endothelial Progenitor Cells - metabolism Female Flow Cytometry Follow-Up Studies Growth factors Heart diseases Humans Inhibitors Kexin Male Medicine Medicine & Public Health Middle Aged Original Article Patients PCSK9 Inhibitors - pharmacology Progenitor cells Proprotein convertases Prospective Studies Repair Stem cells Subtilisin Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular endothelial growth factor receptors
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