Genetic Association of a Gain‐of‐Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet’s Disease

Objective Behçet’s disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. This study was undertaken to investigate genetic associations with Behçet’s disease in a diverse multiethnic population. Methods A total of 9,444 patients and controls from 7 different popul...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-07, Vol.73 (7), p.1244-1252
Hauptverfasser:	Ortiz Fernández, Lourdes, Coit, Patrick, Yilmaz, Vuslat, Yentür, Sibel P., Alibaz‐Oner, Fatma, Aksu, Kenan, Erken, Eren, Düzgün, Nursen, Keser, Gokhan, Cefle, Ayse, Yazici, Ayten, Ergen, Andac, Alpsoy, Erkan, Salvarani, Carlo, Casali, Bruno, Kısacık, Bünyamin, Kötter, Ina, Henes, Jörg, Çınar, Muhammet, Schaefer, Arne, Nohutcu, Rahime M., Zhernakova, Alexandra, Wijmenga, Cisca, Takeuchi, Fujio, Harihara, Shinji, Kaburaki, Toshikatsu, Messedi, Meriam, Song, Yeong‐Wook, Kaşifoğlu, Timuçin, Carmona, F. David, Guthridge, Joel M., James, Judith A., Martin, Javier, González Escribano, María Francisca, Saruhan‐Direskeneli, Güher, Direskeneli, Haner, Sawalha, Amr H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Autoimmune diseases Behcet Syndrome - genetics Behcet Syndrome - immunology Behcet's syndrome Case-Control Studies Chromatin Chromosomes, Human, Pair 10 - genetics Dkk1 protein DNA, Intergenic - genetics Epigenesis, Genetic Epigenetics Etiology Female Gain of Function Mutation Gene expression Gene Expression Regulation Gene polymorphism Genetic factors Genetic Predisposition to Disease Genotyping Health risks Humans Inflammation Intercellular Signaling Peptides and Proteins - genetics Interferon gamma Receptor Interleukin 1 Interleukin 10 Lipopolysaccharides Loci Male Molecular modelling Monocytes Monocytes - immunology Polymorphism Polymorphism, Single Nucleotide Receptors, Interferon - genetics Receptors, Interferon - immunology RNA, Long Noncoding - genetics RNA, Messenger - metabolism Susceptibility Vasculitis Vein & artery diseases
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