ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes

Purpose Amplification of 8p12 is frequent in breast cancer and associated with poor prognosis in luminal subtypes. ZNF703 has been identified as the driver gene of proliferation in the A1 amplicon situated in 8p12. In this study, the aims were to investigate associations between ZNF703 copy number a...

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Veröffentlicht in:	Breast cancer research and treatment 2021-02, Vol.186 (1), p.65-77
Hauptverfasser:	Klæstad, Elise, Sawicka, Joanna Ewa, Engstrøm, Monica Jernberg, Ytterhus, Borgny, Valla, Marit, Bofin, Anna Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - genetics Cancer Cancer research Carrier Proteins - genetics Cell Proliferation - genetics Copy number Female Fluorescence in situ hybridization Gene Dosage Genes Genetic aspects Humans Immunohistochemistry In Situ Hybridization, Fluorescence Lymph nodes Medicine Medicine & Public Health Metastases Metastasis Oncology Preclinical Study Prognosis Protein expression Proteins Tumors
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