Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats
Methicillin-resistant Staphylococcus aureus (MRSA) is considered one of the most serious multidrug-resistant bacteria worldwide. MRSA resistance to methicillin antibiotics made vancomycin, the acceptable treatment option. Silver nanoparticles (Ag-NPs) are among the well-known antibacterial substance...
Gespeichert in:
| Veröffentlicht in: | Biological trace element research 2021-11, Vol.199 (11), p.4225-4236 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4236 |
|---|---|
| container_issue | 11 |
| container_start_page | 4225 |
| container_title | Biological trace element research |
| container_volume | 199 |
| creator | Awad, Mohammed Yosri, Mohamed Abdel-Aziz, Marwa M. Younis, Ahmed M. Sidkey, Nagwa M. |
| description | Methicillin-resistant
Staphylococcus aureus
(MRSA) is considered one of the most serious multidrug-resistant bacteria worldwide. MRSA resistance to methicillin antibiotics made vancomycin, the acceptable treatment option. Silver nanoparticles (Ag-NPs) are among the well-known antibacterial substances showing multimode antibacterial action. Therefore, Ag-NPs are appropriate applicants for use in combination with vancomycin in order to augment its antibacterial action. This study aimed to biosynthesize silver nanoparticles and to evaluate its antibacterial activity against MRSA alone and when combined with vancomycin both in vitro and in vivo.
Agaricus bisporus
is used to reduce the silver nitrate salts in solution to yield silver nanoparticles which was characterized by UV-visible spectrophotometric analysis that shows maximum absorption at 420 nm as a preliminary confirmation for nanoparticles synthesis, Energy-Dispersive Analysis of X-ray (EDX) which confirms the crystalline nature of silver nanoparticles and transmission electron microscopy (TEM) image shows the particles in spherical form with mean size 27.45 nm. The synthesized silver nanoparticles were tested for antibacterial activity against MRSA, and the synergetic effects of the combination of silver nanoparticles and vancomycin were evaluated. The results showed a strong synergistic antibacterial effect between Ag-NPs and vancomycin in vitro with fractional inhibitory concentration 0.37 and in vivo against MRSA strain. The result revealed that mycosynthesized silver nanoparticles (NPs) enhance the in vitro and in vivo antibacterial activity of vancomycin against MRSA. These results suggested that sliver nanoparticles have an effective antibacterial activity against MRSA count, histopathology, and liver enzymes as well as protective immune response specially when combined with vancomycin in the lungs of infected rats with MRSA. |
| doi_str_mv | 10.1007/s12011-020-02561-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2475094204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2575661278</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5f80aee3dacf1ba95552a3b6eb58356cfc0b30a8243d5c0a1996683b902112933</originalsourceid><addsrcrecordid>eNp9kctu1DAUhi0EotPCC7BAltiwCfgSO8lyGEEZqVzUAlvL8Zx0XCX24OOAhhXvwNPwOjwJLlNAYsHCsqX_83cs_4Q84OwJZ6x5ilwwzismWFlK80rfIguuVFexRrDbZMG4llXdtfUROUa8Yow3opN3yZGUsu00bxfk-xIRECcImcaB5i3QZci-ty5D8nakb2Mu2fWpxM98xH0oEPovsKEXfvwEib62Ie5syt6NgHQVp96Hkn72eUs_2ODitHc-0OWl9QEzfQV5650fRx-q82LCbMvwi2x32_0YXXRuRmrnBDP--PptHTazK7Z1GMBlHwMtqnOb8R65M9gR4f7NfkLev3j-bvWyOntzul4tzyonG5UrNbTMAsiNdQPvbaeUElb2GnrVSqXd4FgvmW1FLTfKMcu7TutW9h0TnJffkifk8cG7S_HjDJjN5NHBONoAcUYj6kaxrhasLuijf9CrOKdQXmeEapTWXDRtocSBcikiJhjMLvnJpr3hzFwXaw7FmlKs-VWs0eXSwxv13E-w-XPld5MFkAcASxQuIf2d_R_tT1Tss0c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2575661278</pqid></control><display><type>article</type><title>Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats</title><source>SpringerNature Journals</source><creator>Awad, Mohammed ; Yosri, Mohamed ; Abdel-Aziz, Marwa M. ; Younis, Ahmed M. ; Sidkey, Nagwa M.</creator><creatorcontrib>Awad, Mohammed ; Yosri, Mohamed ; Abdel-Aziz, Marwa M. ; Younis, Ahmed M. ; Sidkey, Nagwa M.</creatorcontrib><description>Methicillin-resistant
Staphylococcus aureus
(MRSA) is considered one of the most serious multidrug-resistant bacteria worldwide. MRSA resistance to methicillin antibiotics made vancomycin, the acceptable treatment option. Silver nanoparticles (Ag-NPs) are among the well-known antibacterial substances showing multimode antibacterial action. Therefore, Ag-NPs are appropriate applicants for use in combination with vancomycin in order to augment its antibacterial action. This study aimed to biosynthesize silver nanoparticles and to evaluate its antibacterial activity against MRSA alone and when combined with vancomycin both in vitro and in vivo.
Agaricus bisporus
is used to reduce the silver nitrate salts in solution to yield silver nanoparticles which was characterized by UV-visible spectrophotometric analysis that shows maximum absorption at 420 nm as a preliminary confirmation for nanoparticles synthesis, Energy-Dispersive Analysis of X-ray (EDX) which confirms the crystalline nature of silver nanoparticles and transmission electron microscopy (TEM) image shows the particles in spherical form with mean size 27.45 nm. The synthesized silver nanoparticles were tested for antibacterial activity against MRSA, and the synergetic effects of the combination of silver nanoparticles and vancomycin were evaluated. The results showed a strong synergistic antibacterial effect between Ag-NPs and vancomycin in vitro with fractional inhibitory concentration 0.37 and in vivo against MRSA strain. The result revealed that mycosynthesized silver nanoparticles (NPs) enhance the in vitro and in vivo antibacterial activity of vancomycin against MRSA. These results suggested that sliver nanoparticles have an effective antibacterial activity against MRSA count, histopathology, and liver enzymes as well as protective immune response specially when combined with vancomycin in the lungs of infected rats with MRSA.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02561-6</identifier><identifier>PMID: 33389618</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antibacterial activity ; Antibiotics ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Defence mechanisms ; Electron microscopy ; Evaluation ; Gold ; Histopathology ; Image transmission ; Immune response ; Immunity ; Life Sciences ; Methicillin ; Multidrug resistance ; Nanoparticles ; Nutrition ; Oncology ; Salts ; Silver ; Silver nitrate ; Spectrophotometry ; Staphylococcus aureus ; Staphylococcus infections ; Synergism ; Transmission electron microscopy ; Vancomycin</subject><ispartof>Biological trace element research, 2021-11, Vol.199 (11), p.4225-4236</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5f80aee3dacf1ba95552a3b6eb58356cfc0b30a8243d5c0a1996683b902112933</citedby><cites>FETCH-LOGICAL-c375t-5f80aee3dacf1ba95552a3b6eb58356cfc0b30a8243d5c0a1996683b902112933</cites><orcidid>0000-0003-2140-0655 ; 0000-0001-7225-8658 ; 0000-0001-9775-1430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02561-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02561-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33389618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awad, Mohammed</creatorcontrib><creatorcontrib>Yosri, Mohamed</creatorcontrib><creatorcontrib>Abdel-Aziz, Marwa M.</creatorcontrib><creatorcontrib>Younis, Ahmed M.</creatorcontrib><creatorcontrib>Sidkey, Nagwa M.</creatorcontrib><title>Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Methicillin-resistant
Staphylococcus aureus
(MRSA) is considered one of the most serious multidrug-resistant bacteria worldwide. MRSA resistance to methicillin antibiotics made vancomycin, the acceptable treatment option. Silver nanoparticles (Ag-NPs) are among the well-known antibacterial substances showing multimode antibacterial action. Therefore, Ag-NPs are appropriate applicants for use in combination with vancomycin in order to augment its antibacterial action. This study aimed to biosynthesize silver nanoparticles and to evaluate its antibacterial activity against MRSA alone and when combined with vancomycin both in vitro and in vivo.
Agaricus bisporus
is used to reduce the silver nitrate salts in solution to yield silver nanoparticles which was characterized by UV-visible spectrophotometric analysis that shows maximum absorption at 420 nm as a preliminary confirmation for nanoparticles synthesis, Energy-Dispersive Analysis of X-ray (EDX) which confirms the crystalline nature of silver nanoparticles and transmission electron microscopy (TEM) image shows the particles in spherical form with mean size 27.45 nm. The synthesized silver nanoparticles were tested for antibacterial activity against MRSA, and the synergetic effects of the combination of silver nanoparticles and vancomycin were evaluated. The results showed a strong synergistic antibacterial effect between Ag-NPs and vancomycin in vitro with fractional inhibitory concentration 0.37 and in vivo against MRSA strain. The result revealed that mycosynthesized silver nanoparticles (NPs) enhance the in vitro and in vivo antibacterial activity of vancomycin against MRSA. These results suggested that sliver nanoparticles have an effective antibacterial activity against MRSA count, histopathology, and liver enzymes as well as protective immune response specially when combined with vancomycin in the lungs of infected rats with MRSA.</description><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Defence mechanisms</subject><subject>Electron microscopy</subject><subject>Evaluation</subject><subject>Gold</subject><subject>Histopathology</subject><subject>Image transmission</subject><subject>Immune response</subject><subject>Immunity</subject><subject>Life Sciences</subject><subject>Methicillin</subject><subject>Multidrug resistance</subject><subject>Nanoparticles</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Salts</subject><subject>Silver</subject><subject>Silver nitrate</subject><subject>Spectrophotometry</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Synergism</subject><subject>Transmission electron microscopy</subject><subject>Vancomycin</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu1DAUhi0EotPCC7BAltiwCfgSO8lyGEEZqVzUAlvL8Zx0XCX24OOAhhXvwNPwOjwJLlNAYsHCsqX_83cs_4Q84OwJZ6x5ilwwzismWFlK80rfIguuVFexRrDbZMG4llXdtfUROUa8Yow3opN3yZGUsu00bxfk-xIRECcImcaB5i3QZci-ty5D8nakb2Mu2fWpxM98xH0oEPovsKEXfvwEib62Ie5syt6NgHQVp96Hkn72eUs_2ODitHc-0OWl9QEzfQV5650fRx-q82LCbMvwi2x32_0YXXRuRmrnBDP--PptHTazK7Z1GMBlHwMtqnOb8R65M9gR4f7NfkLev3j-bvWyOntzul4tzyonG5UrNbTMAsiNdQPvbaeUElb2GnrVSqXd4FgvmW1FLTfKMcu7TutW9h0TnJffkifk8cG7S_HjDJjN5NHBONoAcUYj6kaxrhasLuijf9CrOKdQXmeEapTWXDRtocSBcikiJhjMLvnJpr3hzFwXaw7FmlKs-VWs0eXSwxv13E-w-XPld5MFkAcASxQuIf2d_R_tT1Tss0c</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Awad, Mohammed</creator><creator>Yosri, Mohamed</creator><creator>Abdel-Aziz, Marwa M.</creator><creator>Younis, Ahmed M.</creator><creator>Sidkey, Nagwa M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2140-0655</orcidid><orcidid>https://orcid.org/0000-0001-7225-8658</orcidid><orcidid>https://orcid.org/0000-0001-9775-1430</orcidid></search><sort><creationdate>20211101</creationdate><title>Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats</title><author>Awad, Mohammed ; Yosri, Mohamed ; Abdel-Aziz, Marwa M. ; Younis, Ahmed M. ; Sidkey, Nagwa M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5f80aee3dacf1ba95552a3b6eb58356cfc0b30a8243d5c0a1996683b902112933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Defence mechanisms</topic><topic>Electron microscopy</topic><topic>Evaluation</topic><topic>Gold</topic><topic>Histopathology</topic><topic>Image transmission</topic><topic>Immune response</topic><topic>Immunity</topic><topic>Life Sciences</topic><topic>Methicillin</topic><topic>Multidrug resistance</topic><topic>Nanoparticles</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Salts</topic><topic>Silver</topic><topic>Silver nitrate</topic><topic>Spectrophotometry</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Synergism</topic><topic>Transmission electron microscopy</topic><topic>Vancomycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awad, Mohammed</creatorcontrib><creatorcontrib>Yosri, Mohamed</creatorcontrib><creatorcontrib>Abdel-Aziz, Marwa M.</creatorcontrib><creatorcontrib>Younis, Ahmed M.</creatorcontrib><creatorcontrib>Sidkey, Nagwa M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awad, Mohammed</au><au>Yosri, Mohamed</au><au>Abdel-Aziz, Marwa M.</au><au>Younis, Ahmed M.</au><au>Sidkey, Nagwa M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>199</volume><issue>11</issue><spage>4225</spage><epage>4236</epage><pages>4225-4236</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Methicillin-resistant
Staphylococcus aureus
(MRSA) is considered one of the most serious multidrug-resistant bacteria worldwide. MRSA resistance to methicillin antibiotics made vancomycin, the acceptable treatment option. Silver nanoparticles (Ag-NPs) are among the well-known antibacterial substances showing multimode antibacterial action. Therefore, Ag-NPs are appropriate applicants for use in combination with vancomycin in order to augment its antibacterial action. This study aimed to biosynthesize silver nanoparticles and to evaluate its antibacterial activity against MRSA alone and when combined with vancomycin both in vitro and in vivo.
Agaricus bisporus
is used to reduce the silver nitrate salts in solution to yield silver nanoparticles which was characterized by UV-visible spectrophotometric analysis that shows maximum absorption at 420 nm as a preliminary confirmation for nanoparticles synthesis, Energy-Dispersive Analysis of X-ray (EDX) which confirms the crystalline nature of silver nanoparticles and transmission electron microscopy (TEM) image shows the particles in spherical form with mean size 27.45 nm. The synthesized silver nanoparticles were tested for antibacterial activity against MRSA, and the synergetic effects of the combination of silver nanoparticles and vancomycin were evaluated. The results showed a strong synergistic antibacterial effect between Ag-NPs and vancomycin in vitro with fractional inhibitory concentration 0.37 and in vivo against MRSA strain. The result revealed that mycosynthesized silver nanoparticles (NPs) enhance the in vitro and in vivo antibacterial activity of vancomycin against MRSA. These results suggested that sliver nanoparticles have an effective antibacterial activity against MRSA count, histopathology, and liver enzymes as well as protective immune response specially when combined with vancomycin in the lungs of infected rats with MRSA.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33389618</pmid><doi>10.1007/s12011-020-02561-6</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2140-0655</orcidid><orcidid>https://orcid.org/0000-0001-7225-8658</orcidid><orcidid>https://orcid.org/0000-0001-9775-1430</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4984 |
| ispartof | Biological trace element research, 2021-11, Vol.199 (11), p.4225-4236 |
| issn | 0163-4984 1559-0720 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2475094204 |
| source | SpringerNature Journals |
| subjects | Antibacterial activity Antibiotics Biochemistry Biomedical and Life Sciences Biotechnology Defence mechanisms Electron microscopy Evaluation Gold Histopathology Image transmission Immune response Immunity Life Sciences Methicillin Multidrug resistance Nanoparticles Nutrition Oncology Salts Silver Silver nitrate Spectrophotometry Staphylococcus aureus Staphylococcus infections Synergism Transmission electron microscopy Vancomycin |
| title | Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A22%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20the%20Antibacterial%20Potential%20of%20Biosynthesized%20Silver%20Nanoparticles%20Combined%20with%20Vancomycin%20Against%20Methicillin-Resistant%20Staphylococcus%20aureus%E2%80%93Induced%20Infection%20in%20Rats&rft.jtitle=Biological%20trace%20element%20research&rft.au=Awad,%20Mohammed&rft.date=2021-11-01&rft.volume=199&rft.issue=11&rft.spage=4225&rft.epage=4236&rft.pages=4225-4236&rft.issn=0163-4984&rft.eissn=1559-0720&rft_id=info:doi/10.1007/s12011-020-02561-6&rft_dat=%3Cproquest_cross%3E2575661278%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2575661278&rft_id=info:pmid/33389618&rfr_iscdi=true |