Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia
Purpose To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR. Materials and Methods A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenest...
Gespeichert in:
| Veröffentlicht in: | Cardiovascular and interventional radiology 2021-03, Vol.44 (3), p.376-383 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 383 |
|---|---|
| container_issue | 3 |
| container_start_page | 376 |
| container_title | Cardiovascular and interventional radiology |
| container_volume | 44 |
| creator | Alenezi, Abdullah O. Tai, Elizabeth Jaberi, Arash Brown, Andrew Mafeld, Sebastian Roche-Nagle, Graham |
| description | Purpose
To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR.
Materials and Methods
A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenestrated or branched technique) in a single tertiary centre from 1 January 2008 to 1 September 2019. The study cohort was divided into tertiles based on tPMA measurement performed independently by two observers from a peri-procedural CT scan at the level of mid-L3 vertebral body. The low tertile was considered sarcopaenic. Logistic regression analysis was used to assess the association of tPMA with 30-day mortality and post-procedural complications. Univariable analysis and adjusted multivariable Cox regression were used to assess the association of tPMA with all-cause mortality.
Results
A total of 257 patients comprised 193 males and 64 females with the mean age of 75.4 years (± 6.8) were included. Adjusted multivariable Cox regression revealed an 8% reduction in all-cause mortality for every 1 cm
2
increase in tPMA,
P
|
| doi_str_mv | 10.1007/s00270-020-02721-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2475093158</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2486622633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-fb4199519dcc1d22e447fff4ae5656ceaca5167d1ec028ba8b5d1d38e463399c3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6iRpmvS4yPoBCyt-4S2k6VS77LZr0ir-e7N2VfDgIQwkz7yTeQg5pHBKAeSZB2ASYmDrIxmNYYsMacJZDCp92iZDoDKJqRB0QPa8nwNQoZjYJQPOuVJKwpCMx8UbOo_RrGtts0QfmbJFF4VrU1ssosnj-Daq6ujGtBXWrY_eq_YlujPONiuDdWX2yU5pFh4PNnVEHi4m9-dX8XR2eX0-nsaWS9HGZZ7QLBM0K6ylBWOYJLIsy8SgSEVq0VgjaCoLihaYyo3KRUELrjBJOc8yy0fkpM9duea1Q9_qZeUtLhamxqbzmiVSQMbDigE9_oPOm87V4XeBUmnKWMgMFOsp6xrvHZZ65aqlcR-agl4L1r1gHQTrL8EaQtPRJrrLl1j8tHwbDQDvAR-e6md0v7P_if0EE6iEUw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2486622633</pqid></control><display><type>article</type><title>Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia</title><source>SpringerLink Journals - AutoHoldings</source><creator>Alenezi, Abdullah O. ; Tai, Elizabeth ; Jaberi, Arash ; Brown, Andrew ; Mafeld, Sebastian ; Roche-Nagle, Graham</creator><creatorcontrib>Alenezi, Abdullah O. ; Tai, Elizabeth ; Jaberi, Arash ; Brown, Andrew ; Mafeld, Sebastian ; Roche-Nagle, Graham</creatorcontrib><description>Purpose
To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR.
Materials and Methods
A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenestrated or branched technique) in a single tertiary centre from 1 January 2008 to 1 September 2019. The study cohort was divided into tertiles based on tPMA measurement performed independently by two observers from a peri-procedural CT scan at the level of mid-L3 vertebral body. The low tertile was considered sarcopaenic. Logistic regression analysis was used to assess the association of tPMA with 30-day mortality and post-procedural complications. Univariable analysis and adjusted multivariable Cox regression were used to assess the association of tPMA with all-cause mortality.
Results
A total of 257 patients comprised 193 males and 64 females with the mean age of 75.4 years (± 6.8) were included. Adjusted multivariable Cox regression revealed an 8% reduction in all-cause mortality for every 1 cm
2
increase in tPMA,
P
< 0.05. TPMA was associated with 30-day mortality (OR 0.85, 95% CI 0.75–0.96,
P
< 0.05) and spinal cord ischaemia (SCI) (OR 0.89, 95% CI 0.82–0.97,
P
< 0.05). For remaining post-procedural complications, tPMA was not a useful predictive tool. TPMA correlated negatively with hospital stay length (
r
s
-0.26,
P
< 0.001). Patients with lower tPMA were more likely to be discharged to a rehabilitation center (OR 0.93, 95% CI 0.87–0.98
, P
< 0.05).
Conclusion
Measurement of tPMA can be a useful predictive tool for adverse outcomes after advanced EVAR.
Level of Evidence
Level 3, Retrospective cohort study.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-020-02721-0</identifier><identifier>PMID: 33388870</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aortic aneurysms ; Arterial Interventions ; Cardiology ; Clinical Investigation ; Complications ; Computed tomography ; Imaging ; Ischemia ; Medical records ; Medicine ; Medicine & Public Health ; Mortality ; Muscles ; Nuclear Medicine ; Patients ; Psoas muscle ; Radiology ; Regression analysis ; Rehabilitation ; Sarcopenia ; Spinal cord ; Ultrasound ; Vertebrae</subject><ispartof>Cardiovascular and interventional radiology, 2021-03, Vol.44 (3), p.376-383</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-fb4199519dcc1d22e447fff4ae5656ceaca5167d1ec028ba8b5d1d38e463399c3</citedby><cites>FETCH-LOGICAL-c375t-fb4199519dcc1d22e447fff4ae5656ceaca5167d1ec028ba8b5d1d38e463399c3</cites><orcidid>0000-0002-3423-1427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-020-02721-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-020-02721-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33388870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alenezi, Abdullah O.</creatorcontrib><creatorcontrib>Tai, Elizabeth</creatorcontrib><creatorcontrib>Jaberi, Arash</creatorcontrib><creatorcontrib>Brown, Andrew</creatorcontrib><creatorcontrib>Mafeld, Sebastian</creatorcontrib><creatorcontrib>Roche-Nagle, Graham</creatorcontrib><title>Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR.
Materials and Methods
A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenestrated or branched technique) in a single tertiary centre from 1 January 2008 to 1 September 2019. The study cohort was divided into tertiles based on tPMA measurement performed independently by two observers from a peri-procedural CT scan at the level of mid-L3 vertebral body. The low tertile was considered sarcopaenic. Logistic regression analysis was used to assess the association of tPMA with 30-day mortality and post-procedural complications. Univariable analysis and adjusted multivariable Cox regression were used to assess the association of tPMA with all-cause mortality.
Results
A total of 257 patients comprised 193 males and 64 females with the mean age of 75.4 years (± 6.8) were included. Adjusted multivariable Cox regression revealed an 8% reduction in all-cause mortality for every 1 cm
2
increase in tPMA,
P
< 0.05. TPMA was associated with 30-day mortality (OR 0.85, 95% CI 0.75–0.96,
P
< 0.05) and spinal cord ischaemia (SCI) (OR 0.89, 95% CI 0.82–0.97,
P
< 0.05). For remaining post-procedural complications, tPMA was not a useful predictive tool. TPMA correlated negatively with hospital stay length (
r
s
-0.26,
P
< 0.001). Patients with lower tPMA were more likely to be discharged to a rehabilitation center (OR 0.93, 95% CI 0.87–0.98
, P
< 0.05).
Conclusion
Measurement of tPMA can be a useful predictive tool for adverse outcomes after advanced EVAR.
Level of Evidence
Level 3, Retrospective cohort study.</description><subject>Aortic aneurysms</subject><subject>Arterial Interventions</subject><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>Complications</subject><subject>Computed tomography</subject><subject>Imaging</subject><subject>Ischemia</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Muscles</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Psoas muscle</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Rehabilitation</subject><subject>Sarcopenia</subject><subject>Spinal cord</subject><subject>Ultrasound</subject><subject>Vertebrae</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6iRpmvS4yPoBCyt-4S2k6VS77LZr0ir-e7N2VfDgIQwkz7yTeQg5pHBKAeSZB2ASYmDrIxmNYYsMacJZDCp92iZDoDKJqRB0QPa8nwNQoZjYJQPOuVJKwpCMx8UbOo_RrGtts0QfmbJFF4VrU1ssosnj-Daq6ujGtBXWrY_eq_YlujPONiuDdWX2yU5pFh4PNnVEHi4m9-dX8XR2eX0-nsaWS9HGZZ7QLBM0K6ylBWOYJLIsy8SgSEVq0VgjaCoLihaYyo3KRUELrjBJOc8yy0fkpM9duea1Q9_qZeUtLhamxqbzmiVSQMbDigE9_oPOm87V4XeBUmnKWMgMFOsp6xrvHZZ65aqlcR-agl4L1r1gHQTrL8EaQtPRJrrLl1j8tHwbDQDvAR-e6md0v7P_if0EE6iEUw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Alenezi, Abdullah O.</creator><creator>Tai, Elizabeth</creator><creator>Jaberi, Arash</creator><creator>Brown, Andrew</creator><creator>Mafeld, Sebastian</creator><creator>Roche-Nagle, Graham</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3423-1427</orcidid></search><sort><creationdate>20210301</creationdate><title>Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia</title><author>Alenezi, Abdullah O. ; Tai, Elizabeth ; Jaberi, Arash ; Brown, Andrew ; Mafeld, Sebastian ; Roche-Nagle, Graham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-fb4199519dcc1d22e447fff4ae5656ceaca5167d1ec028ba8b5d1d38e463399c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aortic aneurysms</topic><topic>Arterial Interventions</topic><topic>Cardiology</topic><topic>Clinical Investigation</topic><topic>Complications</topic><topic>Computed tomography</topic><topic>Imaging</topic><topic>Ischemia</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Muscles</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Psoas muscle</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Rehabilitation</topic><topic>Sarcopenia</topic><topic>Spinal cord</topic><topic>Ultrasound</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alenezi, Abdullah O.</creatorcontrib><creatorcontrib>Tai, Elizabeth</creatorcontrib><creatorcontrib>Jaberi, Arash</creatorcontrib><creatorcontrib>Brown, Andrew</creatorcontrib><creatorcontrib>Mafeld, Sebastian</creatorcontrib><creatorcontrib>Roche-Nagle, Graham</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alenezi, Abdullah O.</au><au>Tai, Elizabeth</au><au>Jaberi, Arash</au><au>Brown, Andrew</au><au>Mafeld, Sebastian</au><au>Roche-Nagle, Graham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>44</volume><issue>3</issue><spage>376</spage><epage>383</epage><pages>376-383</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR.
Materials and Methods
A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenestrated or branched technique) in a single tertiary centre from 1 January 2008 to 1 September 2019. The study cohort was divided into tertiles based on tPMA measurement performed independently by two observers from a peri-procedural CT scan at the level of mid-L3 vertebral body. The low tertile was considered sarcopaenic. Logistic regression analysis was used to assess the association of tPMA with 30-day mortality and post-procedural complications. Univariable analysis and adjusted multivariable Cox regression were used to assess the association of tPMA with all-cause mortality.
Results
A total of 257 patients comprised 193 males and 64 females with the mean age of 75.4 years (± 6.8) were included. Adjusted multivariable Cox regression revealed an 8% reduction in all-cause mortality for every 1 cm
2
increase in tPMA,
P
< 0.05. TPMA was associated with 30-day mortality (OR 0.85, 95% CI 0.75–0.96,
P
< 0.05) and spinal cord ischaemia (SCI) (OR 0.89, 95% CI 0.82–0.97,
P
< 0.05). For remaining post-procedural complications, tPMA was not a useful predictive tool. TPMA correlated negatively with hospital stay length (
r
s
-0.26,
P
< 0.001). Patients with lower tPMA were more likely to be discharged to a rehabilitation center (OR 0.93, 95% CI 0.87–0.98
, P
< 0.05).
Conclusion
Measurement of tPMA can be a useful predictive tool for adverse outcomes after advanced EVAR.
Level of Evidence
Level 3, Retrospective cohort study.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33388870</pmid><doi>10.1007/s00270-020-02721-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3423-1427</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2021-03, Vol.44 (3), p.376-383 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2475093158 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Aortic aneurysms Arterial Interventions Cardiology Clinical Investigation Complications Computed tomography Imaging Ischemia Medical records Medicine Medicine & Public Health Mortality Muscles Nuclear Medicine Patients Psoas muscle Radiology Regression analysis Rehabilitation Sarcopenia Spinal cord Ultrasound Vertebrae |
| title | Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T00%3A24%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adverse%20Outcomes%20after%20Advanced%20EVAR%20in%20Patients%20with%20Sarcopaenia&rft.jtitle=Cardiovascular%20and%20interventional%20radiology&rft.au=Alenezi,%20Abdullah%20O.&rft.date=2021-03-01&rft.volume=44&rft.issue=3&rft.spage=376&rft.epage=383&rft.pages=376-383&rft.issn=0174-1551&rft.eissn=1432-086X&rft_id=info:doi/10.1007/s00270-020-02721-0&rft_dat=%3Cproquest_cross%3E2486622633%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2486622633&rft_id=info:pmid/33388870&rfr_iscdi=true |