Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer
Purpose Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung c...
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| Veröffentlicht in: | Supportive care in cancer 2021-07, Vol.29 (7), p.3961-3970 |
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| creator | Okayama, Taro Naito, Tateaki Yonenaga, Yusuke Ohashi, Takuya Kitagawa, Midori Mitsuhashi, Noriko Ishi, Takeshi Fuseya, Hiroshi Aoyama, Takashi Notsu, Akifumi Mori, Keita Mamesaya, Nobuaki Kawamura, Takahisa Kobayashi, Haruki Omori, Shota Wakuda, Kazushige Ono, Akira Kenmotsu, Hirotsugu Murakami, Haruyasu Tanuma, Akira Takahashi, Toshiaki |
| description | Purpose
Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung cancer.
Method
This study prospectively enrolled 60 patients aged ≥ 70 years with advanced non-small-cell lung cancer (NSCLC) scheduled to receive first-line chemotherapy or radical radiotherapy between January 2013 and December 2014 (trial registration number: UMIN000009768). Patients were classified into the mobile or less mobile group based on the median incremental shuttle walking distance (ISWD) before initial treatment. Assessments included the Barthel index, disability-free survival time, mean cumulative lengths of hospital stay, and inpatient medical costs.
Results
The median ISWD was 290 m (interquartile range, 245–357.5 m). The mobile group (ISWD ≥ 290 m) had a longer disability-free survival time than the less mobile group (ISWD < 290 m, 24.6 months vs. 8.4 months,
p
< 0.05). During the first year from study entry, the mobile group had shorter cumulative lengths of hospital stay (41.3 vs. 72.9 days/person,
p
< 0.05) and lower inpatient medical costs (¥1.9 vs. ¥2.9 million/person,
p
< 0.05) than the less mobile group.
Conclusion
Elderly NSCLC patients with adequate walking capacity showed lower risks of disability, shorter hospitalizations, and lower inpatient medical costs than patients with reduced walking capacity. Further prospective research is needed to validate these findings. The trial was registered with the University Hospital Medical Information Network as trial number UMIN000009768 on January 13, 2013.
Trial registration
UMIN000009768 |
| doi_str_mv | 10.1007/s00520-020-05953-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2475090346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A666289934</galeid><sourcerecordid>A666289934</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-727750cbb6b987f28c49983323560c2237461771050a84373a4519815dfd72e23</originalsourceid><addsrcrecordid>eNp9UUuPFCEQJkbjjqt_wIMh8eKlV5qCpjluJr6STbzomdA0PcMuDSPQbsarf1zaWd1ojCEVSH2PKvIh9LwlFy0h4nUmhFPSkLW45NDwB2jTMoBGAMiHaEMkaxsGnJ-hJzlfE9IKweljdAYVp0LABn3fehec0R67-aBNwXHCt9rfuLDDRteOK0ccAy57i5PLNys-uqwH51dEhxHvYz64or37pouLIWM9x6q2frTJH_Ghdm0oGd-6ssd6_KqDsSP2y88J9Z2eokeT9tk-u7vP0ee3bz5t3zdXH9992F5eNYYxWhpRN-bEDEM3yF5MtDdMyh6AAu-IoRQE6-oHW8KJ7hkI0Iy3sm_5OI2CWgrn6NXJ95Dil8XmomaXjfVeBxuXrCir_pIA6yr15V_U67ikULdTlEMdCJSQe9ZOe6tcmGJJ2qym6rLrOtpLCayyLv7Bqme0szMx2MnV_h8CehKYFHNOdlKH5Gadjqolak1enZJXZK01ecWr6MXdxssw2_G35FfUlQAnQq5Q2Nl0_6X_2P4A9OK24w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2533563200</pqid></control><display><type>article</type><title>Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer</title><source>Springer Nature - Complete Springer Journals</source><creator>Okayama, Taro ; Naito, Tateaki ; Yonenaga, Yusuke ; Ohashi, Takuya ; Kitagawa, Midori ; Mitsuhashi, Noriko ; Ishi, Takeshi ; Fuseya, Hiroshi ; Aoyama, Takashi ; Notsu, Akifumi ; Mori, Keita ; Mamesaya, Nobuaki ; Kawamura, Takahisa ; Kobayashi, Haruki ; Omori, Shota ; Wakuda, Kazushige ; Ono, Akira ; Kenmotsu, Hirotsugu ; Murakami, Haruyasu ; Tanuma, Akira ; Takahashi, Toshiaki</creator><creatorcontrib>Okayama, Taro ; Naito, Tateaki ; Yonenaga, Yusuke ; Ohashi, Takuya ; Kitagawa, Midori ; Mitsuhashi, Noriko ; Ishi, Takeshi ; Fuseya, Hiroshi ; Aoyama, Takashi ; Notsu, Akifumi ; Mori, Keita ; Mamesaya, Nobuaki ; Kawamura, Takahisa ; Kobayashi, Haruki ; Omori, Shota ; Wakuda, Kazushige ; Ono, Akira ; Kenmotsu, Hirotsugu ; Murakami, Haruyasu ; Tanuma, Akira ; Takahashi, Toshiaki</creatorcontrib><description>Purpose
Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung cancer.
Method
This study prospectively enrolled 60 patients aged ≥ 70 years with advanced non-small-cell lung cancer (NSCLC) scheduled to receive first-line chemotherapy or radical radiotherapy between January 2013 and December 2014 (trial registration number: UMIN000009768). Patients were classified into the mobile or less mobile group based on the median incremental shuttle walking distance (ISWD) before initial treatment. Assessments included the Barthel index, disability-free survival time, mean cumulative lengths of hospital stay, and inpatient medical costs.
Results
The median ISWD was 290 m (interquartile range, 245–357.5 m). The mobile group (ISWD ≥ 290 m) had a longer disability-free survival time than the less mobile group (ISWD < 290 m, 24.6 months vs. 8.4 months,
p
< 0.05). During the first year from study entry, the mobile group had shorter cumulative lengths of hospital stay (41.3 vs. 72.9 days/person,
p
< 0.05) and lower inpatient medical costs (¥1.9 vs. ¥2.9 million/person,
p
< 0.05) than the less mobile group.
Conclusion
Elderly NSCLC patients with adequate walking capacity showed lower risks of disability, shorter hospitalizations, and lower inpatient medical costs than patients with reduced walking capacity. Further prospective research is needed to validate these findings. The trial was registered with the University Hospital Medical Information Network as trial number UMIN000009768 on January 13, 2013.
Trial registration
UMIN000009768</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-020-05953-5</identifier><identifier>PMID: 33392773</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged patients ; Cancer ; Cancer patients ; Chemotherapy ; Disability ; Hospitalization ; Lung cancer ; Lung cancer, Non-small cell ; Medical colleges ; Medicine ; Medicine & Public Health ; Nursing ; Nursing Research ; Older people ; Oncology ; Oncology, Experimental ; Original Article ; Pain Medicine ; Physical fitness ; Rehabilitation Medicine ; Walking</subject><ispartof>Supportive care in cancer, 2021-07, Vol.29 (7), p.3961-3970</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-727750cbb6b987f28c49983323560c2237461771050a84373a4519815dfd72e23</citedby><cites>FETCH-LOGICAL-c442t-727750cbb6b987f28c49983323560c2237461771050a84373a4519815dfd72e23</cites><orcidid>0000-0003-4047-2929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-020-05953-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-020-05953-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33392773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okayama, Taro</creatorcontrib><creatorcontrib>Naito, Tateaki</creatorcontrib><creatorcontrib>Yonenaga, Yusuke</creatorcontrib><creatorcontrib>Ohashi, Takuya</creatorcontrib><creatorcontrib>Kitagawa, Midori</creatorcontrib><creatorcontrib>Mitsuhashi, Noriko</creatorcontrib><creatorcontrib>Ishi, Takeshi</creatorcontrib><creatorcontrib>Fuseya, Hiroshi</creatorcontrib><creatorcontrib>Aoyama, Takashi</creatorcontrib><creatorcontrib>Notsu, Akifumi</creatorcontrib><creatorcontrib>Mori, Keita</creatorcontrib><creatorcontrib>Mamesaya, Nobuaki</creatorcontrib><creatorcontrib>Kawamura, Takahisa</creatorcontrib><creatorcontrib>Kobayashi, Haruki</creatorcontrib><creatorcontrib>Omori, Shota</creatorcontrib><creatorcontrib>Wakuda, Kazushige</creatorcontrib><creatorcontrib>Ono, Akira</creatorcontrib><creatorcontrib>Kenmotsu, Hirotsugu</creatorcontrib><creatorcontrib>Murakami, Haruyasu</creatorcontrib><creatorcontrib>Tanuma, Akira</creatorcontrib><creatorcontrib>Takahashi, Toshiaki</creatorcontrib><title>Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung cancer.
Method
This study prospectively enrolled 60 patients aged ≥ 70 years with advanced non-small-cell lung cancer (NSCLC) scheduled to receive first-line chemotherapy or radical radiotherapy between January 2013 and December 2014 (trial registration number: UMIN000009768). Patients were classified into the mobile or less mobile group based on the median incremental shuttle walking distance (ISWD) before initial treatment. Assessments included the Barthel index, disability-free survival time, mean cumulative lengths of hospital stay, and inpatient medical costs.
Results
The median ISWD was 290 m (interquartile range, 245–357.5 m). The mobile group (ISWD ≥ 290 m) had a longer disability-free survival time than the less mobile group (ISWD < 290 m, 24.6 months vs. 8.4 months,
p
< 0.05). During the first year from study entry, the mobile group had shorter cumulative lengths of hospital stay (41.3 vs. 72.9 days/person,
p
< 0.05) and lower inpatient medical costs (¥1.9 vs. ¥2.9 million/person,
p
< 0.05) than the less mobile group.
Conclusion
Elderly NSCLC patients with adequate walking capacity showed lower risks of disability, shorter hospitalizations, and lower inpatient medical costs than patients with reduced walking capacity. Further prospective research is needed to validate these findings. The trial was registered with the University Hospital Medical Information Network as trial number UMIN000009768 on January 13, 2013.
Trial registration
UMIN000009768</description><subject>Aged patients</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Chemotherapy</subject><subject>Disability</subject><subject>Hospitalization</subject><subject>Lung cancer</subject><subject>Lung cancer, Non-small cell</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Older people</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Physical fitness</subject><subject>Rehabilitation Medicine</subject><subject>Walking</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9UUuPFCEQJkbjjqt_wIMh8eKlV5qCpjluJr6STbzomdA0PcMuDSPQbsarf1zaWd1ojCEVSH2PKvIh9LwlFy0h4nUmhFPSkLW45NDwB2jTMoBGAMiHaEMkaxsGnJ-hJzlfE9IKweljdAYVp0LABn3fehec0R67-aBNwXHCt9rfuLDDRteOK0ccAy57i5PLNys-uqwH51dEhxHvYz64or37pouLIWM9x6q2frTJH_Ghdm0oGd-6ssd6_KqDsSP2y88J9Z2eokeT9tk-u7vP0ee3bz5t3zdXH9992F5eNYYxWhpRN-bEDEM3yF5MtDdMyh6AAu-IoRQE6-oHW8KJ7hkI0Iy3sm_5OI2CWgrn6NXJ95Dil8XmomaXjfVeBxuXrCir_pIA6yr15V_U67ikULdTlEMdCJSQe9ZOe6tcmGJJ2qym6rLrOtpLCayyLv7Bqme0szMx2MnV_h8CehKYFHNOdlKH5Gadjqolak1enZJXZK01ecWr6MXdxssw2_G35FfUlQAnQq5Q2Nl0_6X_2P4A9OK24w</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Okayama, Taro</creator><creator>Naito, Tateaki</creator><creator>Yonenaga, Yusuke</creator><creator>Ohashi, Takuya</creator><creator>Kitagawa, Midori</creator><creator>Mitsuhashi, Noriko</creator><creator>Ishi, Takeshi</creator><creator>Fuseya, Hiroshi</creator><creator>Aoyama, Takashi</creator><creator>Notsu, Akifumi</creator><creator>Mori, Keita</creator><creator>Mamesaya, Nobuaki</creator><creator>Kawamura, Takahisa</creator><creator>Kobayashi, Haruki</creator><creator>Omori, Shota</creator><creator>Wakuda, Kazushige</creator><creator>Ono, Akira</creator><creator>Kenmotsu, Hirotsugu</creator><creator>Murakami, Haruyasu</creator><creator>Tanuma, Akira</creator><creator>Takahashi, Toshiaki</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature 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cancer</title><author>Okayama, Taro ; Naito, Tateaki ; Yonenaga, Yusuke ; Ohashi, Takuya ; Kitagawa, Midori ; Mitsuhashi, Noriko ; Ishi, Takeshi ; Fuseya, Hiroshi ; Aoyama, Takashi ; Notsu, Akifumi ; Mori, Keita ; Mamesaya, Nobuaki ; Kawamura, Takahisa ; Kobayashi, Haruki ; Omori, Shota ; Wakuda, Kazushige ; Ono, Akira ; Kenmotsu, Hirotsugu ; Murakami, Haruyasu ; Tanuma, Akira ; Takahashi, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-727750cbb6b987f28c49983323560c2237461771050a84373a4519815dfd72e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged patients</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Chemotherapy</topic><topic>Disability</topic><topic>Hospitalization</topic><topic>Lung cancer</topic><topic>Lung cancer, Non-small cell</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Older people</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Physical fitness</topic><topic>Rehabilitation Medicine</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okayama, Taro</creatorcontrib><creatorcontrib>Naito, Tateaki</creatorcontrib><creatorcontrib>Yonenaga, Yusuke</creatorcontrib><creatorcontrib>Ohashi, Takuya</creatorcontrib><creatorcontrib>Kitagawa, Midori</creatorcontrib><creatorcontrib>Mitsuhashi, Noriko</creatorcontrib><creatorcontrib>Ishi, Takeshi</creatorcontrib><creatorcontrib>Fuseya, Hiroshi</creatorcontrib><creatorcontrib>Aoyama, Takashi</creatorcontrib><creatorcontrib>Notsu, Akifumi</creatorcontrib><creatorcontrib>Mori, Keita</creatorcontrib><creatorcontrib>Mamesaya, Nobuaki</creatorcontrib><creatorcontrib>Kawamura, Takahisa</creatorcontrib><creatorcontrib>Kobayashi, Haruki</creatorcontrib><creatorcontrib>Omori, Shota</creatorcontrib><creatorcontrib>Wakuda, Kazushige</creatorcontrib><creatorcontrib>Ono, Akira</creatorcontrib><creatorcontrib>Kenmotsu, Hirotsugu</creatorcontrib><creatorcontrib>Murakami, Haruyasu</creatorcontrib><creatorcontrib>Tanuma, Akira</creatorcontrib><creatorcontrib>Takahashi, Toshiaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium 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Database</collection><collection>Social Science Database</collection><collection>Sociology Database (ProQuest)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okayama, Taro</au><au>Naito, Tateaki</au><au>Yonenaga, Yusuke</au><au>Ohashi, Takuya</au><au>Kitagawa, Midori</au><au>Mitsuhashi, Noriko</au><au>Ishi, Takeshi</au><au>Fuseya, Hiroshi</au><au>Aoyama, Takashi</au><au>Notsu, Akifumi</au><au>Mori, Keita</au><au>Mamesaya, Nobuaki</au><au>Kawamura, Takahisa</au><au>Kobayashi, Haruki</au><au>Omori, Shota</au><au>Wakuda, Kazushige</au><au>Ono, Akira</au><au>Kenmotsu, Hirotsugu</au><au>Murakami, Haruyasu</au><au>Tanuma, Akira</au><au>Takahashi, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>29</volume><issue>7</issue><spage>3961</spage><epage>3970</epage><pages>3961-3970</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung cancer.
Method
This study prospectively enrolled 60 patients aged ≥ 70 years with advanced non-small-cell lung cancer (NSCLC) scheduled to receive first-line chemotherapy or radical radiotherapy between January 2013 and December 2014 (trial registration number: UMIN000009768). Patients were classified into the mobile or less mobile group based on the median incremental shuttle walking distance (ISWD) before initial treatment. Assessments included the Barthel index, disability-free survival time, mean cumulative lengths of hospital stay, and inpatient medical costs.
Results
The median ISWD was 290 m (interquartile range, 245–357.5 m). The mobile group (ISWD ≥ 290 m) had a longer disability-free survival time than the less mobile group (ISWD < 290 m, 24.6 months vs. 8.4 months,
p
< 0.05). During the first year from study entry, the mobile group had shorter cumulative lengths of hospital stay (41.3 vs. 72.9 days/person,
p
< 0.05) and lower inpatient medical costs (¥1.9 vs. ¥2.9 million/person,
p
< 0.05) than the less mobile group.
Conclusion
Elderly NSCLC patients with adequate walking capacity showed lower risks of disability, shorter hospitalizations, and lower inpatient medical costs than patients with reduced walking capacity. Further prospective research is needed to validate these findings. The trial was registered with the University Hospital Medical Information Network as trial number UMIN000009768 on January 13, 2013.
Trial registration
UMIN000009768</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33392773</pmid><doi>10.1007/s00520-020-05953-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4047-2929</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2021-07, Vol.29 (7), p.3961-3970 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2475090346 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Aged patients Cancer Cancer patients Chemotherapy Disability Hospitalization Lung cancer Lung cancer, Non-small cell Medical colleges Medicine Medicine & Public Health Nursing Nursing Research Older people Oncology Oncology, Experimental Original Article Pain Medicine Physical fitness Rehabilitation Medicine Walking |
| title | Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer |
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