Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation

Our understanding of signaling pathways regulating the cell fate of human embryonic stem cells (hESCs) is limited. Calcineurin‐NFAT signaling is associated with a wide range of biological processes and diseases. However, its role in controlling hESC fate remains unclear. Here, we report that calcine...

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Veröffentlicht in:	Journal of cellular physiology 2021-08, Vol.236 (8), p.5698-5714
Hauptverfasser:	Chen, Hao, Zeng, Yanwu, Shao, Min, Zhao, Hanzhi, Fang, Zhuoqing, Gu, Junjie, Liao, Bing, Jin, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biomarkers Calcineurin calcineurin A gamma Cell differentiation Cell fate Cell self-renewal Differentiation (biology) Embryo cells Gene expression Glycoproteins hESC differentiation Mesenchyme NF-AT protein NFATc3 Signaling SRPX2 Stem cells uPAR
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