A potent neutralizing mouse monoclonal antibody specific to dengue virus type 1 Mochizuki strain recognized a novel epitope around the N-67 glycan on the envelope protein: A possible explanation of dengue virus evolution regarding the acquisition of N-67 glycan

•Epitope mapping of a potent dengue neutralizing antibody named 7F4 was conducted.•A novel epitope was identified to the region near the N-67 glycan on the E protein.•7F4 antibody selection pressure might have facilitated dengue virus evolution.•Induction of antibodies to this region is important fo...

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Veröffentlicht in:Virus research 2021-03, Vol.294, p.198278-198278, Article 198278
Hauptverfasser: Kotaki, Tomohiro, Yamanaka, Atsushi, Konishi, Eiji, Kameoka, Masanori
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Sprache:eng
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