Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment

Purpose Lung adenocarcinoma (LUAD) accounts for approximately half of patients in lung cancer. Cancer-associated fibroblasts (CAFs) are the major component in the tumor microenvironment (TME). Targeting CAFs is a promising therapeutic strategy for cancer treatment. However, therapeutic targets of CA...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2021-04, Vol.147 (4), p.1049-1064
Hauptverfasser:	Wei, Tongtong, Song, Jinjing, Liang, Kai, Li, Li, Mo, Xiaoxiang, Huang, Zhiguang, Chen, Gang, Mao, Naiquan, Yang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Bioinformatics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Epithelial cells Extracellular matrix Female Fibroblasts Follow-Up Studies Gene Expression Regulation, Neoplastic Gene Regulatory Networks Gluconeogenesis Glycolysis Hematology Humans Immunofluorescence Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged Oncology Original Article – Cancer Research Patients Prognosis Protein Interaction Maps Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA-Seq Surgery Survival analysis Survival Rate Therapeutic applications Therapeutic targets Tumor cell lines Tumor Cells, Cultured Tumor Microenvironment
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