Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury

•Bari-P hydrogel gels at body temperature and releases baricitinib steadily.•Bari-P hydrogel reduces neuronal apoptosis and promotes functional recovery in SCI.•Bari-P hydrogel inhibiting the JAK2-STAT3-MTORC1 pathway to control inflammation. Aggressive inflammation is an important pathological proc...

Ausführliche Beschreibung