Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes

[Display omitted] •A novel series of 4-(Diethylamino)-Salicylaldehyde (3a-p) thiosemicarbazones was synthesized and characterized.•Probed as cholinesterase, carbonic anhydrase and α-Glycosidase Inhibitors.•SAR showed that aryl halides and hydroxybenzylidene moieties are critical for inhibition of en...

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Veröffentlicht in:	Bioorganic chemistry 2021-02, Vol.107, p.104554-104554, Article 104554
Hauptverfasser:	Hashmi, Sadaf, Khan, Samra, Shafiq, Zahid, Taslimi, Parham, Ishaq, Muhamamd, Sadeghian, Nastaran, Karaman, Halide Sedef, Akhtar, Naeem, Islam, Muhamamd, Asari, Asnuzilawati, Mohamad, Habsah, Gulçin, İlhami
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(Diethylamino)-salicylaldehyde Cholinesterase Molecular docking Multi-target-directed ligands Thiosemicarbazones
Online-Zugang:	Volltext
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