Glioma-Derived TSP2 Promotes Excitatory Synapse Formation and Results in Hyperexcitability in the Peritumoral Cortex of Glioma

Abstract Seizures are common in patients with glioma, especially low-grade glioma (LGG). However, the epileptogenic mechanisms are poorly understood. Recent evidence has indicated that abnormal excitatory synaptogenesis plays an important role in epileptogenesis. The thrombospondin (TSP) family is a...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2021-02, Vol.80 (2), p.137-149
Hauptverfasser:	Wang, Yao-Hui, Huang, Tian-Lan, Chen, Xin, Yu, Si-Xun, Li, Wei, Chen, Tao, Li, Yang, Kuang, Yong-Qin, Shu, Hai-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain tumors Complications and side effects Development and progression Epilepsy Glioma Gliomas Glycoproteins Health aspects Neural transmission Physiological aspects Regulation Synapses
Online-Zugang:	Volltext
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