QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis

The role of RNA binding proteins in regulating the phagocytic and cytokine-releasing functions of microglia is unknown. Here, we show that microglia deficient for the QUAKING (QKI) RNA binding protein have increased proinflammatory cytokine release and defects in processing phagocytosed cargo. Splic...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-12, Vol.33 (13), p.108560-108560, Article 108560
Hauptverfasser:	Lee, Jeesan, Villarreal, Oscar David, Chen, Xiaoru, Zandee, Stéphanie, Young, Yoon Kow, Torok, Cynthia, Lamarche-Vane, Nathalie, Prat, Alexandre, Rivest, Serge, Gosselin, David, Richard, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative splicing microexons microglia myelination QKI Rho GTPase, RNA-binding protein, QUAKING, phagocytosis
Online-Zugang:	Volltext
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