Mesenchymal stromal cell treatment of donor kidneys during ex vivo normothermic machine perfusion: A porcine renal autotransplantation study

Normothermic machine perfusion (NMP) of injured kidneys offers the opportunity for interventions to metabolically active organs prior to transplantation. Mesenchymal stromal cells (MSCs) can exert regenerative and anti‐inflammatory effects in ischemia‐reperfusion injury. The aims of this study were...

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Veröffentlicht in:	American journal of transplantation 2021-07, Vol.21 (7), p.2348-2359
Hauptverfasser:	Lohmann, Stine, Pool, Merel B. F., Rozenberg, Kaithlyn M., Keller, Anna K., Moers, Cyril, Møldrup, Ulla, Møller, Bjarne K., Lignell, Stina J. M., Krag, Søren, Sierra‐Parraga, Jesus M., Lo Faro, Maria L., Hunter, James, Hoogduijn, Martin J., Baan, Carla C., Leuvenink, Henri G. D., Ploeg, Rutger J., Eijken, Marco, Jespersen, Bente
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basic (laboratory) research/science Creatinine donors and donation: donation after circulatory death (DCD) Gelatinase Glomerular filtration rate Hemodynamics Humans Inflammation Ischemia ischemia reperfusion injury (IRI) Kidney kidney transplantation/nephrology Kidney transplants Kidneys Leukocytes (neutrophilic) Lipocalin Mesenchymal Stem Cells Mesenchyme Nephrectomy organ perfusion and preservation Organ Preservation organ procurement and allocation Perfusion regenerative medicine Renal cortex Reperfusion stem cells Stromal cells Swine Transplantation Transplantation, Autologous
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