Tolerance of dinutuximab therapy for treatment of high‐risk neuroblastoma in two patients with end‐stage renal disease on dialysis

Autologous hematopoietic cell transplant (aHCT) has a significant survival advantage in patients with high‐risk (HR) neuroblastoma. Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a serious complication and may result in chronic renal disease leading to delay in subsequent posttransplan...

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Veröffentlicht in:Pediatric blood & cancer 2021-03, Vol.68 (3), p.e28852-n/a
Hauptverfasser: Emberesh, Myesa, Rubinstein, Jeremy D., Young, Jennifer, Benoit, Stefanie W., Dandoy, Christopher E., Weiss, Brian D.
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container_issue 3
container_start_page e28852
container_title Pediatric blood & cancer
container_volume 68
creator Emberesh, Myesa
Rubinstein, Jeremy D.
Young, Jennifer
Benoit, Stefanie W.
Dandoy, Christopher E.
Weiss, Brian D.
description Autologous hematopoietic cell transplant (aHCT) has a significant survival advantage in patients with high‐risk (HR) neuroblastoma. Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a serious complication and may result in chronic renal disease leading to delay in subsequent posttransplant therapy and limitations of treatment options. Dinutuximab represents an important therapeutic advance in the treatment of pediatric HR neuroblastoma, but historically has not been administered in patients with GFR 
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Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a serious complication and may result in chronic renal disease leading to delay in subsequent posttransplant therapy and limitations of treatment options. Dinutuximab represents an important therapeutic advance in the treatment of pediatric HR neuroblastoma, but historically has not been administered in patients with GFR &lt; 60 mL/m2/min. 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subjects Autografts
Dialysis
dinutuximab
end‐stage renal disease
Hematology
Immunological tolerance
Immunotherapy
Kidney diseases
Kidney transplantation
Monoclonal antibodies
Neuroblastoma
Oncology
Patients
Pediatrics
Targeted cancer therapy
Thrombotic microangiopathy
transplant‐associated thrombotic microangiopathy
title Tolerance of dinutuximab therapy for treatment of high‐risk neuroblastoma in two patients with end‐stage renal disease on dialysis
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