Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET

Atypical teratoid/rhabdoid tumors (AT/RT) and central nervous system primitive neuroectodermal tumors (CNS-PNET) are pediatric brain tumors with poor survival and life-long negative side effects. Here, the aim was to characterize the efficacy and safety of the oncolytic adenovirus, Delta-24-RGD, whi...

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Veröffentlicht in:	Clinical cancer research 2021-03, Vol.27 (6), p.1807
Hauptverfasser:	Garcia-Moure, Marc, Gonzalez-Huarriz, Marisol, Labiano, Sara, Guruceaga, Elizabeth, Bandres, Eva, Zalacain, Marta, Marrodan, Lucia, de Andrea, Carlos, Villalba, Maria, Martinez-Velez, Naiara, Laspidea, Virginia, Puigdelloses, Montse, Gallego Perez-Larraya, Jaime, Iñigo-Marco, Ignacio, Stripecke, Renata, Chan, Jennifer A, Raabe, Eric H, Kool, Marcel, Gomez-Manzano, Candelaria, Fueyo, Juan, Patiño-García, Ana, Alonso, Marta M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Proliferation Central Nervous System Neoplasms - immunology Central Nervous System Neoplasms - mortality Central Nervous System Neoplasms - pathology Central Nervous System Neoplasms - therapy Female Humans Immunity, Cellular Mice Mice, Inbred C57BL Mice, Nude Neuroectodermal Tumors, Primitive - immunology Neuroectodermal Tumors, Primitive - mortality Neuroectodermal Tumors, Primitive - pathology Neuroectodermal Tumors, Primitive - therapy Oligopeptides - genetics Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Rhabdoid Tumor - immunology Rhabdoid Tumor - mortality Rhabdoid Tumor - pathology Rhabdoid Tumor - therapy Teratoma - immunology Teratoma - mortality Teratoma - pathology Teratoma - therapy Tumor Cells, Cultured Xenograft Model Antitumor Assays
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